Modulating hedgehog signaling can attenuate the severity of osteoarthritis (original) (raw)
Aigner, T., Soder, S., Gebhard, P.M., McAlinden, A. & Haag, J. Mechanisms of disease: role of chondrocytes in the pathogenesis of osteoarthritis--structure, chaos and senescence. Nat. Clin. Pract. Rheumatol.3, 391–399 (2007). ArticleCAS Google Scholar
Slagboom, E. & Meulenbelt, I. Genetics of osteoarthritis: early developmental clues to an old disease. Nat. Clin. Pract. Rheumatol.4, 563 (2008). Article Google Scholar
Mak, K.K., Kronenberg, H.M., Chuang, P.T., Mackem, S. & Yang, Y. Indian hedgehog signals independently of PTHrP to promote chondrocyte hypertrophy. Development135, 1947–1956 (2008). ArticleCAS Google Scholar
Maeda, Y. et al. Indian Hedgehog produced by postnatal chondrocytes is essential for maintaining a growth plate and trabecular bone. Proc. Natl. Acad. Sci. USA104, 6382–6387 (2007). ArticleCAS Google Scholar
Hilton, M.J., Tu, X. & Long, F. Tamoxifen-inducible gene deletion reveals a distinct cell type associated with trabecular bone, and direct regulation of PTHrP expression and chondrocyte morphology by Ihh in growth region cartilage. Dev. Biol.308, 93–105 (2007). ArticleCAS Google Scholar
Kobayashi, T. et al. Indian hedgehog stimulates periarticular chondrocyte differentiation to regulate growth plate length independently of PTHrP. J. Clin. Invest.115, 1734–1742 (2005). ArticleCAS Google Scholar
Vortkamp, A. et al. Regulation of rate of cartilage differentiation by Indian hedgehog and PTH-related protein. Science273, 613–622 (1996). ArticleCAS Google Scholar
Lanske, B. et al. PTH/PTHrP receptor in early development and Indian hedgehog-regulated bone growth. Science273, 663–666 (1996). ArticleCAS Google Scholar
Arai, M. et al. Effect of adenovirus-mediated overexpression of bovine ADAMTS-4 and human ADAMTS-5 in primary bovine articular chondrocyte pellet culture system. Osteoarthritis Cartilage12, 599–613 (2004). Article Google Scholar
Mak, K.K. et al. Hedgehog signaling in mature osteoblasts regulates bone formation and resorption by controlling PTHrP and RANKL expression. Dev. Cell14, 674–688 (2008). ArticleCAS Google Scholar
Mainil-Varlet, P. et al. Histological assessment of cartilage repair: a report by the Histology Endpoint Committee of the International Cartilage Repair Society (ICRS). J. Bone Joint Surg. Am. 85-A Suppl 2, 45–57 (2003). Article Google Scholar
Glasson, S.S. et al. Deletion of active ADAMTS5 prevents cartilage degradation in a murine model of osteoarthritis. Nature434, 644–648 (2005). ArticleCAS Google Scholar
Tchetina, E.V., Squires, G. & Poole, A.R. Increased type II collagen degradation and very early focal cartilage degeneration is associated with upregulation of chondrocyte differentiation related genes in early human articular cartilage lesions. J. Rheumatol.32, 876–886 (2005). CASPubMed Google Scholar
Lark, M.W. et al. Aggrecan degradation in human cartilage. Evidence for both matrix metalloproteinase and aggrecanase activity in normal, osteoarthritic, and rheumatoid joints. J. Clin. Invest.100, 93–106 (1997). ArticleCAS Google Scholar
Billinghurst, R.C. et al. Enhanced cleavage of type II collagen by collagenases in osteoarthritic articular cartilage. J. Clin. Invest.99, 1534–1545 (1997). ArticleCAS Google Scholar
Parfitt, A.M. et al. Bone histomorphometry: standardization of nomenclature, symbols, and units. Report of the ASBMR Histomorphometry Nomenclature Committee. J. Bone Miner. Res.2, 595–610 (1987). ArticleCAS Google Scholar
Krenn, V. et al. Synovitis score: discrimination between chronic low-grade and high-grade synovitis. Histopathology49, 358–364 (2006). ArticleCAS Google Scholar
Goodrich, L.V., Milenkovic, L., Higgins, K.M. & Scott, M.P. Altered neural cell fates and medulloblastoma in mouse patched mutants. Science277, 1109–1113 (1997). ArticleCAS Google Scholar
Hopyan, S. et al. A mutant PTH/PTHrP type I receptor in enchondromatosis. Nat. Genet.30, 306–310 (2002). Article Google Scholar
Jeong, J., Mao, J., Tenzen, T., Kottmann, A.H. & McMahon, A.P. Hedgehog signaling in the neural crest cells regulates the patterning and growth of facial primordia. Genes Dev.18, 937–951 (2004). ArticleCAS Google Scholar
Grover, J. & Roughley, P.J. Generation of a transgenic mouse in which Cre recombinase is expressed under control of the type II collagen promoter and doxycycline administration. Matrix Biol.25, 158–165 (2006). ArticleCAS Google Scholar
Ho, L. et al. Gli2 and p53 cooperate to regulate IGFBP-3- mediated chondrocyte apoptosis in the progression from benign to malignant cartilage tumors. Cancer Cell16, 126–136 (2009). ArticleCAS Google Scholar
Zhang, X.M., Ramalho-Santos, M. & McMahon, A.P. Smoothened mutants reveal redundant roles for Shh and Ihh signaling including regulation of L/R symmetry by the mouse node. Cell106, 781–792 (2001). ArticleCAS Google Scholar
Romer, J.T. et al. Suppression of the Shh pathway using a small molecule inhibitor eliminates medulloblastoma in Ptc1(+/−)p53(−/−) mice. Cancer Cell6, 229–240 (2004). ArticleCAS Google Scholar
Williams, J.A. et al. Identification of a small molecule inhibitor of the hedgehog signaling pathway: effects on basal cell carcinoma-like lesions. Proc. Natl. Acad. Sci. USA100, 4616–4621 (2003). ArticleCAS Google Scholar
Hopyan, S., Nadesan, P., Yu, C., Wunder, J. & Alman, B.A. Dysregulation of hedgehog signalling predisposes to synovial chondromatosis. J. Pathol.206, 143–150 (2005). ArticleCAS Google Scholar
Tiet, T.D. et al. Constitutive hedgehog signaling in chondrosarcoma up-regulates tumor cell proliferation. Am. J. Pathol.168, 321–330 (2006). ArticleCAS Google Scholar
Sarangi, A. et al. Targeted inhibition of the Hedgehog pathway in established malignant glioma xenografts enhances survival. Oncogene28, 3468–3476 (2009). ArticleCAS Google Scholar
Thirunavukkarasu, K., Pei, Y. & Wei, T. Characterization of the human ADAMTS-5 (aggrecanase-2) gene promoter. Mol. Biol. Rep.34, 225–231 (2007). ArticleCAS Google Scholar
Kamekura, S. et al. Contribution of runt-related transcription factor 2 to the pathogenesis of osteoarthritis in mice after induction of knee joint instability. Arthritis Rheum.54, 2462–2470 (2006). ArticleCAS Google Scholar
Shimoyama, A. et al. Ihh/Gli2 signaling promotes osteoblast differentiation by regulating Runx2 expression and function. Mol. Biol. Cell18, 2411–2418 (2007). ArticleCAS Google Scholar
Takamoto, M. et al. Hedgehog signaling enhances core-binding factor a1 and receptor activator of nuclear factor-kappaB ligand (RANKL) gene expression in chondrocytes. J. Endocrinol.177, 413–421 (2003). ArticleCAS Google Scholar
Li, Y. et al. Transduction of passaged human articular chondrocytes with adenoviral, retroviral, and lentiviral vectors and the effects of enhanced expression of SOX9. Tissue Eng.10, 575–584 (2004). ArticleCAS Google Scholar
Ng, T.C., Chiu, K.W., Rabie, A.B. & Hagg, U. Repeated mechanical loading enhances the expression of Indian hedgehog in condylar cartilage. Front. Biosci.11, 943–948 (2006). ArticleCAS Google Scholar
Adams, M.E., Matyas, J.R., Huang, D. & Dourado, G.S. Expression of proteoglycans and collagen in the hypertrophic phase of experimental osteoarthritis. J. Rheumatol. Suppl.43, 94–97 (1995). CASPubMed Google Scholar
Adams, S.L., Cohen, A.J. & Lassova, L. Integration of signaling pathways regulating chondrocyte differentiation during endochondral bone formation. J. Cell. Physiol.213, 635–641 (2007). ArticleCAS Google Scholar
Yoshida, C.A. et al. Runx2 and Runx3 are essential for chondrocyte maturation, and Runx2 regulates limb growth through induction of Indian hedgehog. Genes Dev.18, 952–963 (2004). ArticleCAS Google Scholar
Wunder, J.S., Nielsen, T.O., Maki, R.G., O'Sullivan, B. & Alman, B.A. Opportunities for improving the therapeutic ratio for patients with sarcoma. Lancet Oncol.8, 513–524 (2007). Article Google Scholar
Steinert, A.F. et al. Major biological obstacles for persistent cell-based regeneration of articular cartilage. Arthritis Res. Ther.9, 213 (2007). Article Google Scholar
Everts, V. & Buttle, D.J. Methods in studying ECM degradation. Methods45, 86–92 (2008). ArticleCAS Google Scholar
Taniguchi, H. et al. Transcriptional silencing of hedgehog-interacting protein by CpG hypermethylation and chromatic structure in human gastrointestinal cancer. J. Pathol.213, 131–139 (2007). ArticleCAS Google Scholar