Inhibitors of leucine-rich repeat kinase-2 protect against models of Parkinson's disease (original) (raw)

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Acknowledgements

We thank C. Burris and L. Lotta for packaging helper virus–free amplicons. C. Cook, K. Kehoe, J. Dunmore and C. Eckman provided technical support for some of the in vivo HSV studies. We also thank G. and K. Caldwell and S. Hamamichi for helpful discussions. This work was supported by grants from the US National Institutes of Health, P50NS38377, R01ES014470 (K.A.M.-Z.), R01-AG023593 (W.J.B.), R00-NS058111 (A.B.W.), NS36420 (H.J.F.) and Army Medical Research and Materiel Command, DAMD17-02-1-0695 (H.J.F.), the Mayo Foundation and the Michael J. Fox Foundation.

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Author notes

  1. Andrew B West
    Present address: Present address: Center for Neurodegeneration and Experimental Therapeutics, University of Alabama School of Medicine, Birmingham, Alabama, USA.,
  2. Valina L Dawson and Ted M Dawson: These authors contributed equally to this work.

Authors and Affiliations

  1. Neuroregeneration and Stem Cell Programs, Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Byoung Dae Lee, Joo-Ho Shin, Andrew B West, Han Seok Ko, Yun-Il Lee, Valina L Dawson & Ted M Dawson
  2. Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Byoung Dae Lee, Joo-Ho Shin, Andrew B West, Han Seok Ko, Yun-Il Lee, Valina L Dawson & Ted M Dawson
  3. Department of Neuroscience, Mayo Clinic College of Medicine, Jacksonville, Florida, USA
    Jackalina VanKampen & Leonard Petrucelli
  4. Department of Neuroscience, Georgetown University Medical Center, Washington, DC, USA
    Kathleen A Maguire-Zeiss
  5. Department of Neurology, Center for Neural Development and Disease, University of Rochester Medical Center, Rochester, New York, USA
    William J Bowers
  6. Office of the Executive Vice President and Executive Dean, Georgetown University Medical Center, Washington, DC, USA
    Howard J Federoff
  7. Department of Neurology, Georgetown University Medical Center, Washington, DC, USA
    Howard J Federoff
  8. Solomon H. Snyder Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Valina L Dawson & Ted M Dawson
  9. Department of Physiology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Valina L Dawson

Authors

  1. Byoung Dae Lee
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  2. Joo-Ho Shin
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  3. Jackalina VanKampen
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  4. Leonard Petrucelli
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  5. Andrew B West
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  6. Han Seok Ko
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  7. Yun-Il Lee
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  8. Kathleen A Maguire-Zeiss
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  9. William J Bowers
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  10. Howard J Federoff
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  11. Valina L Dawson
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  12. Ted M Dawson
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Contributions

B.D.L., J.V., L.P., A.B.W., V.L.D. and T.M.D. designed the experiments. B.D.L., J.V., H.S.K., Y.I.L. and J.-H.S. generated data. K.A.M.-Z., W.J.B. and H.J.F. generated HSV-encoded LRRK2s. B.D.L. and J.V. analyzed data. B.D.L., V.L.D. and T.M.D. wrote the manuscript. All authors discussed the results and commented on the manuscript.

Corresponding authors

Correspondence toValina L Dawson or Ted M Dawson.

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Competing interests

T.M.D. is a paid consultant to Merck KGAA. The terms of this arrangement are being managed by the Johns Hopkins University in accordance with its conflict of interest policies.

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Lee, B., Shin, JH., VanKampen, J. et al. Inhibitors of leucine-rich repeat kinase-2 protect against models of Parkinson's disease.Nat Med 16, 998–1000 (2010). https://doi.org/10.1038/nm.2199

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