Mesenchymal stem cell–based tissue regeneration is governed by recipient T lymphocytes via IFN-γ and TNF-α (original) (raw)

• Bianco, P., Riminucci, M., Gronthos, S. & Robey, P.G. Bone marrow stromal stem cells: nature, biology, and potential applications. Stem Cells 19, 180–192 (2001).
  Article CAS Google Scholar
• Friedenstein, A.J., Chailakhyan, R.K., Latsinik, N.V., Panasyuk, A.F. & Keiliss-Borok, I.V. Stromal cells responsible for transferring the microenvironment of the hemopoietic tissues. Cloning in vitro and retransplantation in vivo. Transplantation 17, 331–340 (1974).
  Article CAS Google Scholar
• Owen, M. & Friedenstein, A.J. Stromal stem cells: marrow-derived osteogenic precursors. Ciba Found. Symp. 136, 42–60 (1988).
  CAS Google Scholar
• Pittenger, M.F. et al. Multilineage potential of adult human mesenchymal stem cells. Science 284, 143–147 (1999).
  Article CAS Google Scholar
• Prockop, D.J. Marrow stromal cells as stem cells for nonhematopoietic tissues. Science 276, 71–74 (1997).
  Article CAS Google Scholar
• Caplan, A.I. Adult mesenchymal stem cells for tissue engineering versus regenerative medicine. J. Cell. Physiol. 213, 341–347 (2007).
  Article CAS Google Scholar
• García-Gómez, I. et al. Mesenchymal stem cells: biological properties and clinical applications. Expert Opin. Biol. Ther. 10, 1453–1468 (2010).
  Article Google Scholar
• Tasso, R., Fais, F., Reverberi, D., Tortelli, F. & Cancedda, R. The recruitment of two consecutive and different waves of host stem/progenitor cells during the development of tissue-engineered bone in a murine model. Biomaterials 31, 2121–2129 (2010).
  Article CAS Google Scholar
• Bueno, E.M. & Glowacki, J. Cell-free and cell-based approaches for bone regeneration. Nat. Rev. Rheumatol. 5, 685–697 (2009).
  Article Google Scholar
• Zhao, S. et al. Immunomodulatory properties of mesenchymal stromal cells and their therapeutic consequences for immune-mediated disorders. Stem Cells Dev. 19, 607–614 (2010).
  Article CAS Google Scholar
• Tolar, J., Le Blanc, K., Keating, A. & Blazar, B.R. Concise review: hitting the right spot with mesenchymal stromal cells. Stem Cells 28, 1446–1455 (2010).
  Article Google Scholar
• English, K., French, A. & Wood, K.J. Mesenchymal stromal cells: facilitators of successful transplantation? Cell Stem Cell 7, 431–442 (2010).
  Article CAS Google Scholar
• Sun, L. et al. Mesenchymal stem cell transplantation reverses multi-organ dysfunction in systemic lupus erythematosus mice and humans. Stem Cells 27, 1421–1432 (2009).
  Article CAS Google Scholar
• Spaggiari, G.M., Capobianco, A., Becchetti, S., Mingari, M.C. & Moretta, L. Mesenchymal stem cell-natural killer cell interactions: evidence that activated NK cells are capable of killing MSCs, whereas MSCs can inhibit IL-2–induced NK-cell proliferation. Blood 107, 1484–1490 (2006).
  Article CAS Google Scholar
• Yamaza, T. et al. Pharmacologic stem cell based intervention as a new approach to osteoporosis treatment in rodents. PLoS ONE 3, e2615 (2008).
  Article Google Scholar
• Lourenço, E.V. & La Cava, A. Natural regulatory T cells in autoimmunity. Autoimmunity 44, 33–42 (2011).
  Article Google Scholar
• Zhou, X. et al. Therapeutic potential of TGF-β–induced CD4+ Foxp3+ regulatory T cells in autoimmune diseases. Autoimmunity 44, 43–50 (2011).
  Article CAS Google Scholar
• Shevach, E.M. CD4+CD25+ suppressor T cells: more question than answers. Nat. Rev. Immunol. 2, 389–400 (2002).
  Article CAS Google Scholar
• van Mierlo, G.J. et al. Cutting edge: TNFR-shedding by CD4+CD25+ regulatory T cells inhibits the induction of inflammatory mediators. J. Immunol. 180, 2747–2751 (2008).
  Article CAS Google Scholar
• Ura, K. et al. Interleukin (IL)-4 and IL-13 inhibit the differentiation of murine osteoblastic MC3T3-E1 cells. Endocr. J. 47, 293–302 (2000).
  Article CAS Google Scholar
• Krebsbach, P.H. et al. Bone formation in vivo: comparison of osteogenesis by transplanted mouse and human marrow stromal fibroblasts. Transplantation 63, 1059–1069 (1997).
  Article CAS Google Scholar
• Batouli, S. et al. Comparison of stem cell–mediated osteogenesis and dentinogenesis. J. Dent. Res. 82, 976–981 (2003).
  Article CAS Google Scholar
• Kwon, M.S. et al. Effect of aspirin and acetaminophen on proinflammatory cytokine-induced pain behavior in mice. Pharmacology 74, 152–156 (2005).
  Article CAS Google Scholar
• Kwan, M.D., Slater, B.J., Wan, D.C. & Longaker, M.T. Cell-based therapies for skeletal regenerative medicine. Hum. Mol. Genet. 17, R93–R98 (2008).
  Article CAS Google Scholar
• Panetta, N.J., Gupta, D.M., Quarto, N. & Longaker, M.T. Mesenchymal cells for skeletal tissue engineering. Panminerva Med. 51, 25–41 (2009).
  CAS PubMed Google Scholar
• Fredericks, D.C. et al. Cellular interactions and bone healing responses to a novel porous tricalcium phosphate bone graft material. Orthopedics 27, s167–s173 (2004).
  PubMed Google Scholar
• Seong, J.M. et al. Stem cells in bone tissue engineering. Biomed. Mater. 5, 062001 (2010).
  Article Google Scholar
• Undale, A.H., Westendorf, J.J., Yaszemski, M.J. & Khosla, S. Mesenchymal stem cells for bone repair and metabolic bone diseases. Mayo Clin. Proc. 84, 893–902 (2009).
  Article CAS Google Scholar
• Kogianni, G. et al. Fas/CD95 is associated with glucocorticoid-induced osteocyte apoptosis. Life Sci. 75, 2879–2895 (2004).
  Article CAS Google Scholar
• Hess, S. & Engelmann, H. A novel function of CD40: induction of cell death in transformed cells. J. Exp. Med. 183, 159–167 (1996).
  Article CAS Google Scholar
• Li, J.Y. et al. Ovariectomy disregulates osteoblast and osteoclast formation through the T-cell receptor CD40 ligand. Proc. Natl. Acad. Sci. USA 108, 768–773 (2011).
  Article CAS Google Scholar
• Ahuja, S.S. et al. CD40 ligand blocks apoptosis induced by tumor necrosis factor α, glucocorticoids, and etoposide in osteoblasts and the osteocyte-like cell line murine long bone osteocyte-Y4. Endocrinology 144, 1761–1769 (2003).
  Article CAS Google Scholar
• Schrum, L.W. et al. Functional CD40 expression induced following bacterial infection of mouse and human osteoblasts. Infect. Immun. 71, 1209–1216 (2003).
  Article CAS Google Scholar
• Li, Z. et al. IFN-γ enhances HOS and U2OS cell lines susceptibility to γδ T cell–mediated killing through the Fas/Fas ligand pathway. Int. Immunopharmacol. 11, 496–503 (2011).
  Article CAS Google Scholar
• Shen, R. et al. Smad6 intereacts with Runx2 and mediates Smad ubiquitin regulatory factor 1–induced Runx2 degradation. J. Biol. Chem. 281, 3569–3576 (2006).
  Article CAS Google Scholar
• Itoh, F. et al. Promoting bone morphogenetic protein signaling through negative regulation of inhibitory Smads. EMBO J. 20, 4132–4142 (2001).
  Article CAS Google Scholar
• Qin, J.Z. et al. Role of NF-κB in the apoptotic-resistant phenotype of keratinocytes. J. Biol. Chem. 274, 37957–37964 (1999).
  Article CAS Google Scholar
• Moon, D.O., Kim, M.O., Kang, S.H., Choi, Y.H. & Kim, G.Y. Sulforaphane suppresses TNF-α–mediated activation of NF-kappaB and induces apoptosis through activation of reactive oxygen species-dependent caspase-3. Cancer Lett. 274, 132–142 (2009).
  Article CAS Google Scholar
• Buckland, M. et al. Aspirin-treated human DCs up-regulate ILT-3 and induce hyporesponsiveness and regulatory activity in responder T cells. Am. J. Transplant. 6, 2046–2059 (2006).
  Article CAS Google Scholar
• Shi, S. et al. Bone formation by human postnatal bone marrow stromal stem cells is enhanced by telomerase expression. Nat. Biotechnol. 20, 587–591 (2002).
  Article CAS Google Scholar