Identification of the Niemann-Pick C1–like 1 cholesterol absorption receptor as a new hepatitis C virus entry factor (original) (raw)

• Uprichard, S.L. Hepatitis C virus experimental model systems and antiviral drug research. Virol. Sin. 25, 227–245 (2010).
  Article CAS PubMed PubMed Central Google Scholar
• Gupta, E.K. & Ito, M.K. Ezetimibe: the first in a novel class of selective cholesterol-absorption inhibitors. Heart Dis. 4, 399–409 (2002).
  Article CAS PubMed Google Scholar
• Garcia-Calvo, M. et al. The target of ezetimibe is Niemann-Pick C1-like 1 (NPC1L1). Proc. Natl. Acad. Sci. USA 102, 8132–8137 (2005).
  Article CAS PubMed Google Scholar
• Pileri, P. et al. Binding of hepatitis C virus to CD81. Science 282, 938–941 (1998).
  Article CAS PubMed Google Scholar
• Scarselli, E. et al. The human scavenger receptor class B type I is a novel candidate receptor for the hepatitis C virus. EMBO J. 21, 5017–5025 (2002).
  Article CAS PubMed PubMed Central Google Scholar
• Evans, M.J. et al. Claudin-1 is a hepatitis C virus co-receptor required for a late step in entry. Nature 446, 801–805 (2007).
  Article CAS PubMed Google Scholar
• Ploss, A. et al. Human occludin is a hepatitis C virus entry factor required for infection of mouse cells. Nature 457, 882–886 (2009).
  Article CAS PubMed PubMed Central Google Scholar
• Liu, S. et al. Tight junction proteins claudin-1 and occludin control hepatitis C virus entry and are downregulated during infection to prevent superinfection. J. Virol. 83, 2011–2014 (2009).
  Article CAS PubMed Google Scholar
• Tscherne, D.M. et al. Time- and temperature-dependent activation of hepatitis C virus for low-pH–triggered entry. J. Virol. 80, 1734–1741 (2006).
  Article CAS PubMed PubMed Central Google Scholar
• Meertens, L., Bertaux, C. & Dragic, T. Hepatitis C virus entry requires a critical postinternalization step and delivery to early endosomes via clathrin-coated vesicles. J. Virol. 80, 11571–11578 (2006).
  Article CAS PubMed PubMed Central Google Scholar
• Huang, H. et al. Hepatitis C virus production by human hepatocytes dependent on assembly and secretion of very low-density lipoproteins. Proc. Natl. Acad. Sci. USA 104, 5848–5853 (2007).
  Article CAS PubMed Google Scholar
• Gastaminza, P. et al. Cellular determinants of hepatitis C virus assembly, maturation, degradation, and secretion. J. Virol. 82, 2120–2129 (2008).
  Article CAS PubMed Google Scholar
• Aizaki, H. et al. Critical role of virion-associated cholesterol and sphingolipid in hepatitis C virus infection. J. Virol. 82, 5715–5724 (2008).
  Article CAS PubMed PubMed Central Google Scholar
• Kapadia, S.B., Barth, H., Baumert, T., McKeating, J.A. & Chisari, F.V. Initiation of hepatitis C virus infection is dependent on cholesterol and cooperativity between CD81 and scavenger receptor B type I. J. Virol. 81, 374–383 (2007).
  Article CAS PubMed Google Scholar
• Yu, L. The structure and function of Niemann-Pick C1–like 1 protein. Curr. Opin. Lipidol. 19, 263–269 (2008).
  Article CAS PubMed Google Scholar
• Altmann, S.W. et al. Niemann-Pick C1 like 1 protein is critical for intestinal cholesterol absorption. Science 303, 1201–1204 (2004).
  Article CAS PubMed Google Scholar
• Sané, A.T. et al. Localization and role of NPC1L1 in cholesterol absorption in human intestine. J. Lipid Res. 47, 2112–2120 (2006).
  Article PubMed Google Scholar
• Bays, H.E., Neff, D., Tomassini, J.E. & Tershakovec, A.M. Ezetimibe: cholesterol lowering and beyond. Expert Rev. Cardiovasc. Ther. 6, 447–470 (2008).
  Article CAS PubMed Google Scholar
• Chang, T.Y. & Chang, C. Ezetimibe blocks internalization of the NPC1L1/cholesterol complex. Cell Metab. 7, 469–471 (2008).
  Article CAS PubMed Google Scholar
• Weinglass, A.B. et al. Extracellular loop C of NPC1L1 is important for binding to ezetimibe. Proc. Natl. Acad. Sci. USA 105, 11140–11145 (2008).
  Article CAS PubMed Google Scholar
• Gottwein, J.M. et al. Development and characterization of hepatitis C virus genotype 1–7 cell culture systems: role of CD81 and scavenger receptor class B type I and effect of antiviral drugs. Hepatology 49, 364–377 (2009).
  Article CAS PubMed Google Scholar
• Grove, J. et al. Scavenger receptor BI and BII expression levels modulate hepatitis C virus infectivity. J. Virol. 81, 3162–3169 (2007).
  Article CAS PubMed PubMed Central Google Scholar
• Zaitseva, E., Yang, S.T., Melikov, K., Pourmal, S. & Chernomordik, L.V. Dengue virus ensures its fusion in late endosomes using compartment-specific lipids. PLoS Pathog. 6, e1001131 (2010).
  Article PubMed PubMed Central Google Scholar
• Coller, K.E. et al. RNA interference and single particle tracking analysis of hepatitis C virus endocytosis. PLoS Pathog. 5, e1000702 (2009).
  Article PubMed PubMed Central Google Scholar
• Zhang, J.H. et al. The N-terminal domain of NPC1L1 protein binds cholesterol and plays essential roles in cholesterol uptake. J. Biol. Chem. 286, 25088–25097 (2011).
  Article CAS PubMed PubMed Central Google Scholar
• Yamamoto, M. et al. Structural requirements of virion-associated cholesterol for infectivity, buoyant density and apolipoprotein association of hepatitis C virus. J. Gen. Virol. 92, 2082–2087 (2011).
  Article CAS PubMed Google Scholar
• Farquhar, M.J. & McKeating, J.A. Primary hepatocytes as targets for hepatitis C virus replication. J. Viral Hepat. 15, 849–854 (2008).
  Article CAS PubMed PubMed Central Google Scholar
• Zhong, J. et al. Persistent hepatitis C virus infection in vitro: coevolution of virus and host. J. Virol. 80, 11082–11093 (2006).
  Article CAS PubMed PubMed Central Google Scholar
• Kneteman, N.M. & Toso, C. In vivo study of HCV in mice with chimeric human livers. Methods Mol. Biol. 510, 383–399 (2009).
  Article CAS PubMed Google Scholar
• Lupberger, J. et al. EGFR and EphA2 are host factors for hepatitis C virus entry and possible targets for antiviral therapy. Nat. Med. 17, 589–595 (2011).
  Article CAS PubMed PubMed Central Google Scholar
• Sweeney, M.E. & Johnson, R.R. Ezetimibe: an update on the mechanism of action, pharmacokinetics and recent clinical trials. Expert Opin. Drug Metab. Toxicol. 3, 441–450 (2007).
  Article CAS PubMed Google Scholar
• Betters, J.L. & Yu, L. Transporters as drug targets: discovery and development of NPC1L1 inhibitors. Clin. Pharmacol. Ther. 87, 117–121 (2010).
  Article CAS PubMed Google Scholar
• Davies, J.P., Scott, C., Oishi, K., Liapis, A. & Ioannou, Y.A. Inactivation of NPC1L1 causes multiple lipid transport defects and protects against diet-induced hypercholesterolemia. J. Biol. Chem. 280, 12710–12720 (2005).
  Article CAS PubMed Google Scholar
• Davis, H.R. Jr. et al. Niemann-Pick C1 like 1 (NPC1L1) is the intestinal phytosterol and cholesterol transporter and a key modulator of whole-body cholesterol homeostasis. J. Biol. Chem. 279, 33586–33592 (2004).
  Article CAS PubMed Google Scholar
• Matsumura, T. et al. Amphipathic DNA polymers inhibit hepatitis C virus infection by blocking viral entry. Gastroenterology 137, 673–681 (2009).
  Article CAS PubMed PubMed Central Google Scholar
• Wakita, T. et al. Production of infectious hepatitis C virus in tissue culture from a cloned viral genome. Nat. Med. 11, 791–796 (2005).
  Article CAS PubMed PubMed Central Google Scholar
• Sabahi, A. et al. The rate of hepatitis C virus infection initiation in vitro is directly related to particle density. Virology 407, 110–119 (2010).
  Article CAS PubMed PubMed Central Google Scholar
• Yu, X. & Uprichard, S.L. Cell-based hepatitis C virus infection fluorescence resonance energy transfer (FRET) assay for antiviral compound screening. Curr. Protoc. Microbiol. 18, 17.5.1–17.5.27 (2010).
  Google Scholar
• Ge, L. et al. The cholesterol absorption inhibitor ezetimibe acts by blocking the sterol-induced internalization of NPC1L1. Cell Metab. 7, 508–519 (2008).
  Article CAS PubMed Google Scholar
• Tateno, C. et al. Near completely humanized liver in mice shows human-type metabolic responses to drugs. Am. J. Pathol. 165, 901–912 (2004).
  Article CAS PubMed PubMed Central Google Scholar