MSCs: science and trials (original) (raw)

Nature Medicine volume 19, page 812 (2013)Cite this article

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To the Editor:

In a recent Perspective, Bianco et al.1 addressed a number of misconceptions regarding the biological nature and function of bone marrow–derived mesenchymal stem cells (MSCs) and their impact on current efforts to achieve clinically successful MSC-based therapies. The MSC committee of the International Society of Cell Therapy (ISCT) applauds this endeavor and strongly supports a number of opinions articulated in the Perspective. For example, the committee agrees that the widespread use of qualitative metrics to evaluate multipotency in vitro has led to the erroneous conclusion that virtually all adherent cells derived from connective tissues represent functionally equivalent MSC populations that are equally potent from a clinical perspective. Indeed, Bianco et al.1 correctly point out that the use of organ-specific stem cells to treat organ-specific diseases provides the greatest probability of successfully translating stem cell science into clinical therapies.

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References

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Authors and Affiliations

  1. Department of Molecular Therapeutics, The Scripps Research Institute, Jupiter, Florida, USA
    Donald G Phinney
  2. Departments of Hematology and Oncology and Pediatrics, Emory University Winship Cancer Institute, Atlanta, Georgia, USA
    Jacques Galipeau
  3. Department of Medicine, Stem Cell Research Laboratory, Section of Hematology, University of Verona, Verona, Italy
    Mauro Krampera
  4. Department of Surgery, University Hospital Basel, Basel, Switzerland
    Ivan Martin
  5. Department of Biomedicine, University Hospital Basel, Basel, Switzerland
    Ivan Martin
  6. Institute of Health Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, and Shanghai Jiao Tong University School of Medicine, Shanghai, China
    Yufang Shi
  7. Etablissement Français du Sang (EFS), Saint-Denis, France
    Luc Sensebe
  8. Unités Mixtes de Recherche (UMR) 5273 STROMALab, Centre National de la Recherche Scientifique (CNRS)/EFS/Unités Propres de Service (UPS)–Institut National de la Santé et de la Recherche Médicale (INSERM) U1031, Toulouse, France
    Luc Sensebe

Authors

  1. Donald G Phinney
  2. Jacques Galipeau
  3. Mauro Krampera
  4. Ivan Martin
  5. Yufang Shi
  6. Luc Sensebe

Corresponding author

Correspondence toDonald G Phinney.

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The authors declare no competing financial interests.

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Phinney, D., Galipeau, J., Krampera, M. et al. MSCs: science and trials.Nat Med 19, 812 (2013). https://doi.org/10.1038/nm.3220

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