Understanding human immune function using the resources from the Human Functional Genomics Project (original) (raw)

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The human immune system is represented by a complex network of organs, tissues, cells and molecules that evolved primarily to protect the host against infections. However, the immune system influences much more than host defense: it has crucial roles in immune surveillance of malignancies, it inflicts damage in the context of autoimmune and autoinflammatory diseases and it affects host metabolism and aging.

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Acknowledgements

We would like to acknowledge the additional HFGP collaborating institutes as of June 2016: 'Iuliu Hatieganu' University of Medicine and Pharmacy Cluj-Napoca, Romania, University of Medicine Craiova, Romania and Kilimanjaro Christian Medical University College, Moshi, Tanzania. The HFGP is supported by ERC Grants (to M.G.N. and C.W.), the Spinoza Prize (M.G.N., C.W.), the IN-CONTROL Netherlands Heart Institute Grant, the Dutch Digestive Diseases Foundation and Dutch Arthritis Foundation Grants, US National Institutes of Health grants and the Helmsley Charitable Trust (to R.J.X).

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Authors and Affiliations

  1. Department of Internal Medicine and Radboud Center for Infectious Diseases, Radboud University Medical Center, Nijmegen, the Netherlands
    Mihai G Netea, Leo A B Joosten, Marije Oosting, Sanne Smeekens, Martin Jaeger, Rob ter Horst, Richard Notebaart, Norman Pavelka, Rahajeng N Tunjungputri, Wouter van de Heijden, Kiki Schraa, Romana Netea-Maier, Jan Smit, Quirijn de Mast, Frank van de Veerdonk, Bart Jan Kullberg, Cees Tack, Inge van de Munckhof, Joost Rutten, Jacqueline van der Graaf, Jos W M van der Meer, Charles A Dinarello & Andre van der Ven
  2. Department of Genetics, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands
    Yang Li, Vinod Kumar, Raul Raul Aguirre-Gamboa, Morris A Swertz, Lude Franke, Marten Hofker, Iris Jonkers, Mathieu Platteel, Astrid Maatman, Jingyuan Fu, Alexandra Zhernakova & Cisca Wijmenga
  3. Center for Computational and Integrative Biology and Gastrointestinal Unit, Massachusetts General Hospital, Harvard School of Medicine, Boston, Massachusetts, USA
    Melanie Schirmer, Hera Vlamakis, Eric A Franzosa, Aylwin Ng, Daniel Graham, Kara Lassen, Curtis Huttenhouwer & Ramnik J Xavier
  4. Broad Institute of MIT and Harvard University, Cambridge, Massachusetts, USA
    Melanie Schirmer, Hera Vlamakis, Eric A Franzosa, Aylwin Ng, Daniel Graham, Kara Lassen, Curtis Huttenhouwer & Ramnik J Xavier
  5. Singapore Immunology Network (SIgN), A-STAR, Singapore
    Norman Pavelka
  6. Department of Infectious Diseases, University of Colorado, Denver, Denver, Colorado, USA
    Charles A Dinarello
  7. Department of Laboratory Medicine, Laboratory of Medical Immunology, Radboud University Medical Center, Nijmegen, the Netherlands
    Hans Koenen & Irma Joosten

Authors

  1. Mihai G Netea
  2. Leo A B Joosten
  3. Yang Li
  4. Vinod Kumar
  5. Marije Oosting
  6. Sanne Smeekens
  7. Martin Jaeger
  8. Rob ter Horst
  9. Melanie Schirmer
  10. Hera Vlamakis
  11. Richard Notebaart
  12. Norman Pavelka
  13. Raul Raul Aguirre-Gamboa
  14. Morris A Swertz
  15. Rahajeng N Tunjungputri
  16. Wouter van de Heijden
  17. Eric A Franzosa
  18. Aylwin Ng
  19. Daniel Graham
  20. Kara Lassen
  21. Kiki Schraa
  22. Romana Netea-Maier
  23. Jan Smit
  24. Quirijn de Mast
  25. Frank van de Veerdonk
  26. Bart Jan Kullberg
  27. Cees Tack
  28. Inge van de Munckhof
  29. Joost Rutten
  30. Jacqueline van der Graaf
  31. Lude Franke
  32. Marten Hofker
  33. Iris Jonkers
  34. Mathieu Platteel
  35. Astrid Maatman
  36. Jingyuan Fu
  37. Alexandra Zhernakova
  38. Jos W M van der Meer
  39. Charles A Dinarello
  40. Andre van der Ven
  41. Curtis Huttenhouwer
  42. Hans Koenen
  43. Irma Joosten
  44. Ramnik J Xavier
  45. Cisca Wijmenga

Corresponding author

Correspondence toMihai G Netea.

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Competing interests

The authors declare no competing financial interests.

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Netea, M., Joosten, L., Li, Y. et al. Understanding human immune function using the resources from the Human Functional Genomics Project.Nat Med 22, 831–833 (2016). https://doi.org/10.1038/nm.4140

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