Vaccination of patients with B–cell lymphoma using autologous antigen–pulsed dendritic cells (original) (raw)

References

  1. Lynch, R.G. et al. Immunoregulation of murine myeloma cell growth and differentiation: A monoclonal model of B cell differentiation. Immunol. Rev. 48, 45–80 (1979).
    Article CAS Google Scholar
  2. Levy, R., Hatzubia, A., Brown, S., Maloney, D. & Dilley, J. Immunoglobulin idiotype: A tumor-specific antigen for human B-cell lymphomas. in Malignant Lymphomas, ch. 5 (Academic Press, New York, 1982).
    Google Scholar
  3. Maloney, D.G., Kaminski, M.S., Burowski, D., Haimovich, J. & Levy, R. Monoclonal anti-idiotype antibodies against the murine B cell lymphoma 38C13: Characterization and use as probes for the biology of the tumor in vivo and in vitro. Hybridoma 4, 191–209 (1985).
    Article CAS Google Scholar
  4. Miller, R.A., Maloney, D.G., Warnke, R. & Levy, R. Treatment of B-cell lymphoma with monoclonal anti-idiotype antibody. N. Engl. J. Med. 306, 517–522 (1982).
    Article CAS Google Scholar
  5. Maloney, D.G. et al. Monoclonal anti-idiotype antibody therapy of B-cell lymphoma: The addition of a short course of chemotherapy does not interfere with the antitumor effect nor prevent the emergence of idiotype-negative variant cells. Blood 80, 1502–1510 (1992).
    CAS PubMed Google Scholar
  6. Campbell, M.J., Esserman, L., Byars, N.E., Allison, A.C. & Levy, R. Idiotype vaccination against murine B cell lymphoma. Humoral and cellular requirements for the full expression of antitumor immunity. J. Immunol. 145, 1029–1036 (1990).
    CAS PubMed Google Scholar
  7. Tao, M.H. & Levy, R. Idiotype/granulocyte-macrophage colony-stimulating factor fusion protein as a vaccine for B-cell lymphoma. Nature 362, 755758 (1993).
    Article Google Scholar
  8. Chen, T.T., Tao, M.H. & Levy, R. Idiotype-cytokine fusion proteins as cancer vaccines. Relative efficacy of IL-2, IL-4, and granulocyte-macrophage colony-stimulating factor. J. Immunol. 153, 4775–4787 (1994).
    CAS PubMed Google Scholar
  9. George, A.J., Folkard, S.G., Hamblin, T.J. & Stevenson, F.K. Idiotypic vaccination as a treatment for a B cell lymphoma. J. Immunol. 141, 2168–2174 (1988).
    CAS PubMed Google Scholar
  10. Campbell, M.J., Esserman, L. & Levy, R. Immunotherapy of established murine B cell lymphoma: Combination of idiotype immunization and cyclophos-phamide. J. Immunol. 141, 3227–3233 (1988).
    CAS PubMed Google Scholar
  11. Hsu, F.J. et al. Clinical trials of idiotype-specific vaccine in B-cell lymphomas. Ann. NY Acad. Sci. 690, 385–387 (1993).
    Article CAS Google Scholar
  12. Kwak, L.W. et al. Induction of immune responses in patients with B-cell lymphoma against the surface-immunoglobulin idiotype expressed by their tumors. N. Engl. J. Med. 327, 1209–1215 (1992).
    Article CAS Google Scholar
  13. McCabe, B.J. et al. Minimal determinant expressed by a recombinant vaccinia virus elicits therapeutic antitumor cytolytic T lymphocyte responses. Cancer Res. 55, 1741–1747 (1995).
    CAS PubMed PubMed Central Google Scholar
  14. Kantor, J. et al. Immunogenicity and safety of a recombinant vaccinia virus vaccine expressing the carcinoembryonic antigen gene in a nonhuman primate. Cancer Res. 52, 6917–6925 (1992).
    CAS PubMed Google Scholar
  15. Steinman, R.M. The dendritic cell system and its role in irnmunogenicity. Annu Rev. Immunol. 9, 271–296 (1991).
    Article CAS Google Scholar
  16. Larsen, C.P. et al. Regulation of immunostimulatory function and costimula-tory molecule (B7-1 and B7-2) expression on murine dendritic cells. J. Immunol. 152, 5208–5219 (1994).
    CAS PubMed Google Scholar
  17. Hathcock, K.S., Laszlo, G., Pucillo, C., Linsley, P. & Hodes, R.J. Comparative analysis of B7-1 and B7-2 costimulatory ligands: Expression and function. J. Exp. Med. 180, 631–640 (1994).
    Article CAS Google Scholar
  18. Hart, D.N.J. & McKenzie, J.L. Isolation and characterization of human tonsil dendritic cells. J. Exp. Med. 168, 157–170 (1988).
    Article CAS Google Scholar
  19. Freudenthal, P.S. & Steinman, R.M. The distinct surface of human blood dendritic cells, as observed after an improved isolation method. Proc. Natl. Acad. Sci. USA 87, 7698–7702 (1990).
    Article CAS Google Scholar
  20. Macatonia, S.E. et al. Dendritic cells produce IL-12 and direct the development of Thl cells from naive CD4+ T cells. J. Immunol. 154, 5071–5079 (1995).
    CAS PubMed Google Scholar
  21. Pure, E. et al. Antigen processing by epidermal Langerhans cells correlates with the level of biosynthesis of major histocompatibility complex class II molecules and expression of invariant chain. J. Exp. Med. 172, 1459–1469 (1990).
    Article CAS Google Scholar
  22. Inaba, K., Metlay, J.P., Crowley, M.T. & Steinman, R.M. Dendritic cells pulsed with protein antigens in vitro can prime antigen-specific, MHC-restricted T cells in situ. J. Exp. Med. 172, 631–640 (1990).
    Article CAS Google Scholar
  23. Mehta, D.A., Markowicz, S. & Engleman, E.G. Generation of antigen-specific CD8+ CTLs from naive precursors. J. Immunol. 153, 996–1003 (1994).
    Google Scholar
  24. Mehta, D.A., Markowicz, S. & Engleman, E.G. Generation of antigen-specific CD4+ T cell lines from naive precursors. Ear. J. Immunol. 25, 1206–1211 (1995).
    Article Google Scholar
  25. Fagnoni, F.F. et al. Role of B70/B7-2 in CD4+ T cell immune responses induced by dendritic cells. Immunology 85, 467–474 (1995).
    CAS PubMed PubMed Central Google Scholar
  26. Flamand, V. et al. Murine dendritic cells pulsed in vitro with tumor antigen induce tumor resistance in vivo. Eur. J. Immunol. 24, 605–610 (1994).
    Article CAS Google Scholar
  27. Boog, C.J. et al. Abolition of specific immune response defect by immunization with dendritic cells. Nature 318, 59–62 (1985).
    Article CAS Google Scholar
  28. Takamizawa, M., Fagnoni, F., Mehta, D.A., Rivas, A. & Engleman, E.G. Cellular and molecular basis of human gamma delta T cell activation: Role of accessory molecules in alloactivation. J. Clin. Invest. 95 296–303 (1995).
    Article CAS Google Scholar
  29. Carroll, W.L., Thielemans, K., Dilley, J. & Levy, R. Mouse × human heterohy-bridomas as fusion partners with human B cell tumors. J. Immunol. Methods 89, 61–72 (1986).
    Article CAS Google Scholar
  30. Koch, F. et al. Antigen processing in populations of mature murine dendritic cells is caused by subsets of incompletely matured cells. J. Immunol. 155, 93–100 (1995).
    CAS PubMed Google Scholar
  31. Nijman, H.W. et al. Antigen capture and major histocompatibility class II compartments of freshly isolated and cultured human blood dendritic cells. J. Exp. Med. 182, 163–174 (1995).
    Article CAS Google Scholar
  32. Boel, P. et al. BAGE: A new gene encoding an antigen recognized on human melanomas by cytolytic T lymphocytes. Immunity 2, 167–175 (1995).
    Article CAS Google Scholar
  33. Marchand, M., Brasseur, F., van der Bruggen, P., Coulie, P., & Boon, T., Perspectives for immunization of HLA-A1 patients carrying a malignant melanoma expressing gene MAGE-1. Dermatology 186, 278–280 (1993).
    Article CAS Google Scholar
  34. Marland, G., Bakker, A.B.H., Huijbens, R.J.F., Adema, G.J. & Figdor, C.G. Primary immune response induction by dendritic cells. J. Cell. Biol. suppl 21A, 21 (1995).
  35. Kotera, Y., Fontenot, J.D., Pecher, G., Metzgar, R.S. & Finn, O.J. Humoral immunity against a tandem repeat epitope of human mucin MUC-1 in sera from breast, pancreatic, and colon cancer patients. Cancer Res. 54, 2856–2860 (1994).
    CAS PubMed Google Scholar
  36. Caux, C., Dezutter, D.C., Schmitt, D. & Banchereau, J. GM-CSF and TNF-alpha cooperate in the generation of dendritic Langerhans cells. Nature 360, 258–261 (1992).
    Article CAS Google Scholar
  37. Romani, N. et al. Proliferating dendritic cell progenitors in human blood. J. Exp. Med. 180, 83–93 (1994).
    Article CAS Google Scholar
  38. Sallusto, F. & Lanzavecchia, A. Efficient presentation of soluble antigen by cultured human dendritic cells is maintained by granulocyte/macrophage colony-stimulating factor plus interleukin 4 and downregulated by tumor necrosis factor alpha. J. Exp. Med. 179 1109–1118 (1994).
    Article CAS Google Scholar
  39. Hsu, F.J. & Levy, R. Preferential use of the VH4 immunoglobulin gene family by diffuse large cell lymphoma. Blood 86, 3072–3082 (1995).
    CAS PubMed Google Scholar
  40. Grabstein, K. . in Selected Methods in Cellular Immunology (eds. Mishell, B.B. & Shiigi, S.M.) 124–137 (Freeman, San Francisco, 1980).
    Google Scholar

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