Cancer-associated MUC1 mucin inhibits human T-cell proliferation, which is reversible by IL-2 (original) (raw)

References

1. Hanisch, H.-G. et al. Structure of O-linked polyacrosaminoglycans on human skim milk mucin: A novel type of linearly extended poly-_N_-acetyl-lactosamine backbones with Gal β (1-4) GlcNAcb (1-6) repeating units. J. Biol. Chem. 264, 872–883 (1989).
   CAS PubMed Google Scholar
2. Gendler, S., Taylor-Papadimitriou, J., Duhig, T., Rothbard, J. & Burchell, J.A. A highly immunogenic region of a human polymorphic epithelial mucin expressed by carcinomas is made up of tandem repeats. J. Biol. Chem. 263, 12820 (1988).
3. Siddiqui, J. et al. Isolation and sequencing of a cDNA coding for the human DF3 breast carcinoma-associated antigen. Proc. Natl. Acad. Sci. USA 85, 2320 (1988).
   Article CAS Google Scholar
4. Parry, G., Beck, J.C., Moss, L., Bartley, J. & Ojakian, G.K. Determination of apical membrane polarity in mammary epithelial cell cultures: The role of cell-cell, cell-substratum, and membrane-cytoskeleton interactions. Exp. Cell Res. 188, 302–311 (1990).
   Article CAS Google Scholar
5. Zotter, S., Hageman, P.C., Lossnitzer, A., Mooi, W.J. & Hilgers, J. Tissue and tumor distribution of human polymorphic epithelial mucin. Cancer Rev. 11, 55–101 (1988).
   Google Scholar
6. Burchell, J. et al. Development and characterization of breast cancer reactive monoclonal antibodies directed to the core protein of the human milk mucin. Cancer Res. 47, 5476–5482 (1987).
   CAS PubMed Google Scholar
7. Bresalier, R.S. et al. Mucin production by human colonic carcinoma cells correlates with their metastatic potential in animal models of colon cancer metastasis. J. Clin. Invest. 87, 1037–1045 (1991).
   Article CAS Google Scholar
8. Kobayashi, H., Terao, T. & Kawashima, Y. Serum sialyl Tn as an independent predictor of poor prognosis in patients with epithelial ovarian cancer. J. Clin. Oncol. 10, 95–101 (1992).
   Article CAS Google Scholar
9. Nakamori, S., Ota, D.M., Cleary, K.R., Shirotani, K. & Irimura, T. MUC-1 mucin expression as a marker of progression and metastasis of human colorectal carcinoma. Castroenterology 106, 353–361 (1994).
   Article CAS Google Scholar
10. Berruti, A. et al. Prognostic value in predicting overall survival of two mucinous markers: CA 15-3 and CA 125 in breast cancer patients at first relapse of disease. Eur. J. Cancer. 30A, 2082–2084 (1994).
    Article CAS Google Scholar
11. McGuckin, M.A., Walsh, M.D., Hohn, B.G., Ward, B.G. & Wright, R.G. Prognostic significance of MUC-1 epithelial mucin expression in breast cancer. Hum. Pathol. 26, 432–439 (1995).
    Article CAS Google Scholar
12. Hilkens, J. et al. Is episialin/MUC-1 involved in breast cancer progression? Cancer Lett. 90, 27–33 (1995).
    Article CAS Google Scholar
13. Fung, P.Y.S. & Longenecker, B.M. Specific immunosuppressive activity of epiglycanin, a mucin-like glycoprotein secreted by a murine mammary adenocarcinoma (TA3-HA). Cancer Res. 51, 1170–1176 (1991).
    CAS PubMed Google Scholar
14. MacLean, G.D., Reddish, M.A. & Longenecker, B.M. Prognostic significance of preimmunotherapy serum CA27. 29 (MUC-1) mucin level following active specific immunotherapy of metastatic adenocarcinoma patients. J. Immunother. 19, 70–78 (1997).
    Article Google Scholar
15. Reddish, M.A., Maclean, G.D., Poppema, S.A., Berg, A. & Longenecker, B.M. Preimmunotherapy serum CA27. 29 (MUC-1) mucin level and CD69+ lymphocytes correlate with effects of theratope sialyl-Tn-KLH cancer vaccine in active specific immunotherapy. Cancer Immunol. Immunother. 42, 303–309 (1996).
    Article CAS Google Scholar
16. Regimbald, L.H. et al. The breast cancer mucin MUC1 as a novel adhesion ligand for endothelial intercellular adhesion molecule 1 in breast cancer. Cancer Res. 56, 4244–4249 (1996).
    CAS PubMed Google Scholar
17. Gimmi, C.D. et al. Breast cancer-associated antigen, DF3/MUC1, induces apoptosis of activated human T cells. Nature Med. 2, 1367–1370 (1996).
    Article CAS Google Scholar
18. Berd, D. et al. Activation markers on T cells infiltrating melanoma metastases after therapy with dinitrophenyl-conjugated vaccine. Cancer Immunol. Immunother. 39, 141–149 (1994).
    Article CAS Google Scholar
19. Alexander, R.B. et al. Helper T cells infiltrating human renal cell carcinomas have the phenotype of the activated memory-like T lymphocytes. J. Immunother. 17, 39–46 (1995).
    Article CAS Google Scholar
20. Coventry, B.J. et al. Lack of IL-2 cytokine expression despite IL-2 messenger RNA transcription in tumor infiltrating lymphocytes in primary human breast carcinoma. J. Immunol. 156, 3486–3492 (1996).
    CAS PubMed Google Scholar
21. Kurosaka, A. et al. A monoclonal antibody that recognizes a cluster of a disaccharide, NeuAca2 to 6GalNAc, in mucin-type glycoproteins. J. Biol. Chem. 262, 8724–8726 (1988).
    Google Scholar
22. Chan, D.W. et al. Use of Truquant® BR™ RIA for the early detection of breast cancer recurrence in patients with stage II and stage III disease. J. Clin. Oncol. 15, 2322–2328 (1997).
    Article CAS Google Scholar
23. Sad, S. & Mosmann, T.R. Interleukin (IL) 4, in the absence of antigen stimulation, induces an anergy-like state in differentiated CD8+ TC1 cells: Loss of IL-2 synthesis and autonomous proliferation but retention of cytotoxicity and synthesis of other cytokines. J. Exp. Med. 182, 1505–1515 (1995).
    Article CAS Google Scholar
24. Luzzati, A.L. et al. Interferon-gamma (IFN-γ) can counteract the in vitro inhibitory effect of an HIV p24 immunosuppressive heptapeptide. Clin. Exp. Immunol. 105, 403–408 (1996).
    Article CAS Google Scholar
25. Brunner, T. et al. Cell-autonomous Fas (CD95)/Fas-ligand interaction mediates activation-induced apoptosis in T-cell hybridomas. Nature 373, 441–444 (1995).
    Article CAS Google Scholar
26. Barinaga, M. Life-death balance within the cell. Science 274, 724 (1996).
    Article CAS Google Scholar
27. Beverly, B., Kang, S-M., Lenardo, M.J. & Schwartz, R.H. Reversal of in vitro T cell anergy by IL-2 stimulation. Int. Immunol. 4, 661–671 (1992).
    Article CAS Google Scholar
28. Mayumi, H., Umesue, M. & Nomoto, K. Cyclophosphamide-induced immunological tolerance: An overview. Immunobiology 195(2), 129–139 (1996).
    Article CAS Google Scholar
29. Fontenot, J.D. et al. Biophysical characterization of one-, two-, and three- tandem repeats of human mucin (MUC-1) protein core. Cancer Res. 53, 5386–5393 (1993).
    CAS PubMed Google Scholar
30. Bohmig, G.A., Kovarik, J., Holter, W., Pohanka, E. & Zlabinger, G.J. Specific down-regulation of proliferative T cell alloresponsiveness by interference with CD2/LFA-3 and LFA-1/ICAM-1 in vitro. J. Immunol. 152, 3720–3728 (1994).
    CAS PubMed Google Scholar
31. Ding, L. et al. Immunogenicity of synthetic peptides related to the core peptide sequence encoded by the human MUC1 mucin gene: Effect of immunization on the growth of murine mammary adenocarcinoma cells transfected with the human MUC1 gene. Cancer Immunol. Immunother. 36, 9–17 (1992).
    Article Google Scholar
32. Apostolopoulos, V., Loveland, B.E., Pietersz, G.A. & McKenzie, I.F.C. CTL in mice immunized with human mucin 1 are MHC-restricted. J. Immunol. 155, 5089–5095 (1995).
    CAS PubMed Google Scholar
33. Agrawal, B., Reddish, M.A. & Longenecker, B.M. In vitro induction of MUC-1 peptide-specific type 1 T lymphocytes and cytotoxic T lymphocytes responses from healthy multiparous donors. J. Immunol. 157, 2089–2095 (1996).
    CAS PubMed Google Scholar
34. Berd, D., Mastrangelo, M.J., Engstrom, P.F., Paul, A. & Maguire, H. Augmentation of the human immune response by cyclophosphamide. Cancer Res. 42, 4862–4866 (1982).
    CAS PubMed Google Scholar
35. Berd, D. & Mastrangelo, M.J. Effect of low dose cyclophosphamide on the immune system of cancer patients: Depletion of CD4+, 2H4+ suppressor-inducer T cells. Cancer Res. 48, 1671–1675 (1988).
    CAS PubMed Google Scholar
36. Fung, P.Y.S., Madej, M., Koganty, R. & Longenecker, B.M. Active specific immunotherapy of a murine mammary adenocarcinoma using a synthetic tumor-associated glycoconjugate. Cancer Res. 50, 4308–4314 (1990).
    CAS PubMed Google Scholar
37. Agrawal, B., Reddish, M. & Longenecker, B.M. CD30 expression on human CD8+ T cells isolated from peripheral blood lymphocytes of normal donors. J. Immunol. 157, 3229–3234 (1996).
    CAS PubMed Google Scholar
38. Reddish, M., Black, N., Almeida, A., Suresh, M.R. & Longenecker, B.M. Epitope mapping of MAb B27.29 within the peptide core of the malignant breast carcinoma-associated mucin antigen coded for the human MUC1 gene. J. Tumor Marker Oncol. 7, 19–27 (1992).
    Google Scholar

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