Expression of cell-cycle regulators p27Kip1 and cyclin E, alone and in combination, correlate with survival in young breast cancer patients (original) (raw)

Nature Medicine volume 3, pages 222–225 (1997)Cite this article

Abstract

Mutations in certain genes that regulate the cell cycle, such as p16 and p53, are frequently found in human cancers1. However, tumor-specific mutations are uncommon in genes encoding cyclin E and the CDK inhibitor p27Kip1, two cell-cycle regulators that are also thought to contribute to tumor progression2–8. It is now known that levels of both cyclin E and p27 can be controlled by posttranscriptional mechanisms, indicating that expression of these proteins can be altered by means other than simply mutation of their respective genes9,10. Thus, changes in p27 and cyclin E protein levels in tumors might be more common than previously anticipated and may be indicators of tumor behavior.

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Authors and Affiliations

  1. Program in Cancer Biology, C1-10S, Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue North, Seattle, Washington, 98109, USA
    Peggy L. Porter, Gail M. Alexander & Laura A. Gatti
  2. Program in Epidemiology, Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, University of Washington, Seattle, Washington, 98109, USA
    Kathleen E. Malone & Janet R. Daling
  3. Program in Biostatistics, Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, University of Washington, Seattle, Washington, 98109, USA
    Patrick J. Heagerty
  4. Division of Basic Sciences, Fred Hutchinson Cancer Research Center, School of Public Health and Community Medicine, University of Washington, Seattle, Washington, 98109, USA
    Eduardo J. Firpo & James M. Roberts
  5. Department of Pathology, School of Public Health and Community Medicine, University of Washington, Seattle, Washington, 98109, USA
    Peggy L. Porter
  6. Department of Epidemiology, School of Public Health and Community Medicine, University of Washington, Seattle, Washington, 98109, USA
    Kathleen E. Malone & Janet R. Daling
  7. Department of Biostatistics, School of Public Health and Community Medicine, University of Washington, Seattle, Washington, 98109, USA
    Patrick J. Heagerty

Authors

  1. Peggy L. Porter
  2. Kathleen E. Malone
  3. Patrick J. Heagerty
  4. Gail M. Alexander
  5. Laura A. Gatti
  6. Eduardo J. Firpo
  7. Janet R. Daling
  8. James M. Roberts

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Porter, P., Malone, K., Heagerty, P. et al. Expression of cell-cycle regulators p27Kip1 and cyclin E, alone and in combination, correlate with survival in young breast cancer patients.Nat Med 3, 222–225 (1997). https://doi.org/10.1038/nm0297-222

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