Gruss, H.-J. & Dower, S. Tumor necrosis factor ligand superfamily: Involvement in the pathology of malignant lymphoma. Blood85, 3378–3404 (1995). CASPubMed Google Scholar
Suda, T., Takahashi, T., Golstein, P. & Nagata, S. Molecular cloning and expression of the Fas ligand: A novel member of the tumor necrosis factor family. Cell75, 1169–1178 (1993). ArticleCASPubMed Google Scholar
Smith, C.A., Farrah, T. & Goodwin, R.G. The TNF receptor superfamily of cellular and viral proteins: Activation, costimulation, and death. Cell76, 959–962 (1994). ArticleCASPubMed Google Scholar
Suda, T. et al. Expression of the Fas ligand in T-cell-lineage. J. Immunol.154, 3806–3813 (1995). CASPubMed Google Scholar
Vignaux, F. et al. TCR/CD3 coupling to Fas-based cytotoxicity. J. Exp. Med.181, 781–786 (1995). ArticleCASPubMed Google Scholar
Watanabe-Fukunaga, R. et al. The cDNA structure, expression, and chromosomal assignment of the mouse Fas antigen. J. Immunol.148, 1274–1279 (1992). CASPubMed Google Scholar
Adachi, M. et al. Targeted mutation in the Fas gene causes hyperplasia in the peripheral lymphoid organs and liver. Nature Genet.11, 294–300 (1995). ArticleCASPubMed Google Scholar
Adachi, M. et al. Enhanced and accelerated lymphoproliferation in Fas-null mice. Proc. Natl. Acad. Sci. USA (in the press).
Nagata, S. & Suda, T. Fas and Fas ligand: Ipr and gld mutations. Immunol. Today16, 39–43 (1995). ArticleCASPubMed Google Scholar
Griffith, T., Brunner, T., Fletcher, S., Green, D. & Ferguson, T. Fas ligand-induced apoptosis as a mechanism of immune privilege. Science270, 1189–1192 (1995). ArticleCASPubMed Google Scholar
Bellgrau, D. et al. A role for CD9S ligand in preventing graft rejection. Nature377, 630–632 (1995). ArticleCASPubMed Google Scholar
Fisher, G.H. et al. Dominant interfering Fas gene mutations impair apoptosis in a human autoimmune lymphoproliferative syndrome. Cell81, 935–946 (1995). ArticleCASPubMed Google Scholar
Rieux-Laucat, F. et al. Mutations in Fas associated with human lymphoproliferative syndrome and autoimmunity. Science268, 1347–1349 (1995). ArticleCASPubMed Google Scholar
Takahashi, T. et al. Generalized lymphoproliferative disease in mice, caused by a point mutation in the Fas ligand. Cell76, 969–976 (1994). ArticleCASPubMed Google Scholar
Watanabe-Fukunaga, R., Brannan, C.I., Copeland, N.G., Jenkins, N.A., Sc Nagata, S. Lymphoproliferation disorder in mice explained by defects in Fas antigen that mediates apoptosis. Nature 356, 314–317 (1992). ArticleCASPubMed Google Scholar
Hiramatsu, N. et al. Immunohistochemical detection of Fas antigen in liver tissue of patients with chronic hepatitis C. Hepatology19, 1354–1359 (1994). ArticleCASPubMed Google Scholar
Debatin, K.-M. et al. High expression of APO-1 (CD95) on T lymphocytes from human immunodeficiency virus-1-infected children. Blood83, 3101–3103 (1994). CASPubMed Google Scholar
Katsikis, P., Wunderlich, E., Smith, C., Herzenberg, L. & Herzenberg, L. Fas antigen stimulation induces marked apoptosis of T lymphocytes in human immunodeficiency virus-infected individuals. J. Exp. Med.181, 2029–2036 (1995). ArticleCASPubMed Google Scholar
Falk, M.H. et al. Expression of the APO-1 antigen in Burkitt lymphoma cell lines correlates with a shift towards a lymphoblastoid phenotype. Blood79, 3300–3306 (1992). CASPubMed Google Scholar
Ogasawara, J. et al. Lethal effect of the anti-Fas antibody in mice. Nature364, 806–809 (1993). ArticleCASPubMed Google Scholar
Fiers, W. Tumor necrosis factor: Characterization at the molecular, cellular and in vivo level. FEBS Lett.285, 199–212 (1991). ArticleCASPubMed Google Scholar
Vassalli, P. The pathophysiology of tumor necrosis factors. Annu. Rev. Immunol.10, 411–452 (1992). ArticleCASPubMed Google Scholar
Mohler, K.M. et al. Protection against a lethal dose of endotoxin by an inhibitor of tumor necrosis factor processing. Nature370, 218–220 (1994). ArticleCASPubMed Google Scholar
McGeehan, G.M. et al. Regulation of tumor necrosis factor-a processing by a metal-loproteinase inhibitor. Nature 370, 558–561 (1994). ArticleCASPubMed Google Scholar
Gearing, A.J.H. et al. Processing of tumor necrosis factor-a precursor by metallopro-teinases. Nature 370, 555–557 (1994). ArticleCASPubMed Google Scholar
Beutler, B. & Cerami, A. Cachectin and tumor necrosis factor as two sides of the same biological coin. Nature320, 584–588 (1986). ArticleCASPubMed Google Scholar
Tanaka, M., Suda, T., Takahashi, T. & Nagata, S. Expression of the functional soluble form of human Fas ligand in activated lymphocytes. EMBO J.14, 1129–1135 (1995). ArticleCASPubMedPubMed Central Google Scholar
Loughran, T.P., Clonal diseases of large granular lymphocytes. Blood82, 1–14 (1993). PubMed Google Scholar
Takahashi, T. et al. Human Fas ligand: Gene structure, chromosomal location and species specificity. Int. Immunol.6, 1567–1574 (1994). ArticleCASPubMed Google Scholar
Suda, T. & Nagata, S. Purification and characterization of the Fas ligand that induces apoptosis. J. Exp. Med.179, 873–878 (1994). ArticleCASPubMed Google Scholar
Tagawa, S. et al. Transformation of large granular lymphocytic leukemia during the course of a reactive human herpesvirus-6 infection. Leukemia6, 465–469 (1992). CASPubMed Google Scholar
Tagawa, S., Hatakeyama, M., Shibano, M., Taniguchi, T. & Kitani, T. The expression of the p75 subunit of interleukin 2 receptor in Tac negative leukemic cells of two patients with large granular lymphocytic leukemia. Blood71, 1161–1164 (1988). CASPubMed Google Scholar
Kagi, D. et al. Fas and perform pathway as major mechanisms of T cell-mediated cvtotoxicity. Science265, 528–530 (1994). ArticleCASPubMed Google Scholar
Kojima, H. et al. Two distinct pathways of specific killing revealed by perforin mutant cytotoxic T lymphocytes. Immunity1, 357–364 (1994). ArticleCASPubMed Google Scholar
Lowin, B., Hahne, M., Mattmann, C. & Tschopp, J., T-cell cytotoxicity is mediated through perforin and Fas lytic pathways. Nature370, 650–652 (1994). ArticleCASPubMed Google Scholar
Kataoka, T. et al. Acidification is essential for maintaining the structure and function of lytic granules of CTL. J. Immunol.153, 3938–3947 (1994). CASPubMed Google Scholar
Chehimi, J. et al. Natural killer (NK) cell stimulatory factor increases the cytotoxic activity of NK cells from both healthy donors and human immunodeficiency virus-infected patients. J. Exp. Med.175, 789–796 (1992). ArticleCASPubMed Google Scholar
Iwai, K. et al. Differential expression of bcl-2 and susceptibility to anti-Fas-mediated cell death in peripheral blood lymphocytes, monocytes, and neutrophils. Blood84, 1201–1208 (1994). CASPubMed Google Scholar
Kagi, D. et al. Cytotoxicity mediated by T cells and natural killer cells is greatly impaired in perforin-deficient mice. Nature369, 31–37 (1994). ArticleCASPubMed Google Scholar
Arase, H., Arase, N. & Saito, T. Fas-mediated cytotoxicity by freshly isolated natural killer cells. J. Exp. Med.181, 1235–1238 (1995). ArticleCASPubMed Google Scholar
Leithauser, F. et al. Constitutive and induced expression of APO-1, a new member of the nerve growth factor/tumor necrosis factor receptor superfamily, in normal and neoplastic cells. Lab. Invest.69, 415–429 (1993). CASPubMed Google Scholar
Owen-Schaub, L.B., Meterissian, S. & Ford, R.J. Fas/APO-1 expression and function on malignant cells of hematologic and nonhematologic origin. J. Immunother.14, 234–241 (1993). ArticleCAS Google Scholar
Gumperz, J.E. & Parham, P. The enigma of the natural killer cell. Nature 378, 245–248 (1995). ArticleCASPubMed Google Scholar
Yokoyama, W. Natural killer cell receptors specific for major rustocompatibility complex class I molecule. Proc. Natl. Acad. Sci. USA92, 3081–3085 (1995). ArticleCASPubMedPubMed Central Google Scholar
Ameisen, J., Estaquier, J., Idziorek, T. & De Bels, F. Programmed cell death and AIDS: Significance, perspective and unanswered questions. Cell Death Differ.2, 9–22 (1995). CASPubMed Google Scholar
Gougeon, M. Does apoptosis contribute to CD4 T cell depletion in human immunodeficiency virus infection? Cell Death Differ.2, 1–8 (1995). CASPubMed Google Scholar
Enari, M., Hug, H. & Nagata, S. Involvement of an ICE-like protease in Fas-mediated apoptosis. Nature375, 78–81 (1995). ArticleCASPubMed Google Scholar
Clare, J.J. et al. Production of mouse epidermal growth factor in yeast: High-level secretion using Pichia pastoris strains containing multiple gene copies. Gene105, 205–212 (1991). ArticleCASPubMed Google Scholar