Block the FAS, lose the fat (original) (raw)

Nature Medicine volume 8, pages 335–336 (2002) Cite this article

A small-molecular-weight drug originally developed to treat cancer produces sustained reduction in body weight in obese mice by a novel hypothalamic mechanism. The findings suggest new targets for the development of anti-obesity drugs.

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Figure 1: Model of how nutrients and hormones converge on the pathway mediating effects of FAS inhibitors on body weight.

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Authors and Affiliations

  1. Neurobiology of Aging Laboratories Mt. Sinai School of Medicine, New York, New York, USA
    Charles V. Mobbs & Hideo Makimura

Authors

  1. Charles V. Mobbs
  2. Hideo Makimura

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Mobbs, C., Makimura, H. Block the FAS, lose the fat.Nat Med 8, 335–336 (2002). https://doi.org/10.1038/nm0402-335

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