Viral vector-mediated transduction of a modified platelet factor 4 cDNA inhibits angiogenesis and tumor growth (original) (raw)

References

1. Folkman, J. Tumor angiogenesis: Therapeutic implications. New Engl. J. Med. 285, 1182–1186 (1971).
   Article CAS PubMed Google Scholar
2. Brem, S., Cotran, R. & Folkman, J. Tumor angiogenesis: A quantitative method for histologic grading. J.Natl. Cancer Inst. 48, 347–356 (1972).
   CAS PubMed Google Scholar
3. Brem, S. The role of vascular proliferation in the growth of brain tumors. Clin. Neurosurg. 23, 440–453 (1976).
   Article CAS PubMed Google Scholar
4. Maxwell, M. et al. Expression of angiogenic growth factor genes in primary human astrocytomas may contribute to their growth and progression. Cancer Res. 51, 1345–1351 (1991).
   CAS PubMed Google Scholar
5. Shweiki, D., Itin, A., Softer, D. & Keshet, E. Vascular endothelial growth factor induced by hypoxia may mediate hypoxia-initiated angiogenesis. Nature 359, 843–845 (1992).
   Article CAS PubMed Google Scholar
6. Plate, K.H., Breier, G. Weich, H.A. & Risau, W. Vascular endothelial growth factor is a potential tumour angiogenesis factor in human gliomas in vivo. Nature 359, 845–848 (1992).
   Article CAS PubMed Google Scholar
7. O'Reilly, M.S. et al. Angiostatin: A novel angiostatin inhibitor that mediates the suppression of metastases by a Lewis lung carcinoma. Cell 79, 315–328 (1994).
   Article CAS PubMed Google Scholar
8. Ingber, D. et al. Synthetic analogues of fumagillin that inhibit angiogenesis and suppress tumor growth. Nature 348, 555–557 (1990).
   Article CAS PubMed Google Scholar
9. D'Amato, R.J., Loughnan, M.S., Flynn, E. & Folkman, J. Thalidomide is an inhibitor of angiogenesis. Proc. Natl. Acad. Sci. USA 91, 4082–4085 (1994).
   Article CAS PubMed PubMed Central Google Scholar
10. Maione, T.E. et al. Inhibition of angiogenesis by recombinant human platelet factor-4 and related peptides. Science 247, 77–79 (1990).
    Article CAS PubMed Google Scholar
11. Maione, T.E., Gray, G.S., Hunt, A.J. & Sharpe, R.J. Inhibition of tumor growth in mice by an analogue of platelet factor 4 that lacks affinity for heparin and retains potent angiostatic activity. Cancer Res. 51, 2077–2083 (1991).
    CAS PubMed Google Scholar
12. Sharpe, R.J., Byers, H.R., Scott, C.F., Bauer, S.I. & Maione, T.E. Growth inhibition of murine melanoma and human colon carcinoma by recombinant human platelet factor 4. J. Natl. Cancer Inst. 82, 848–853 (1990).
    Article CAS PubMed Google Scholar
13. Staddon, A. & Bonnem, E. A randomized dose finding study of recombinant platelet factor 4 (rPF4) in cutaneous AIDS-related Kaposi's sarcoma (KS). Proc. Am. Soc. Clin. Oncol. 13, 3 (1994).
14. O'Reilly, M.S., Holmgren, L., Chen, C. & Folkman, J. Angiostatin induces and sustains dormancy of human primary tumors in mice. Nature Med. 2, 689–692 (1996).
    Article CAS PubMed Google Scholar
15. Millauer, B., Shawver, L.K., Plate, K.H., Risau, W. & Ullrich, A. Glioblastoma growth inhibited in vivo by a dominant-negative Flk-1mutant. Nature 367, 576–579 (1994).
    Article CAS PubMed Google Scholar
16. Weinstat-Saslow, D.L., Zabrenetzky, V.S., Frazier, W.A., Roberts, D.D. & Steeg, P.S. Transfection of thrombospondin 1 complementary DNA into a human breast carcinoma Cell line reduces primary tumor growth, metastatic potential and angiogenesis. Cancer Res. 54, 6504–6511 (1994).
    CAS PubMed Google Scholar
17. Millauer, B. et al. Dominant-negative inhibition of Flk-1 suppresses the growth of many tumor types in vivo. Cancer Res. 56, 1615–1620 (1996).
    CAS PubMed Google Scholar
18. Rice, C.D. & Merchant, R.E. Systemic treatment with murine recombinant interleukin-1β inhibits the growth and progression of malignant glioma in the rat. J. Neuro-Oncol. 13, 43–55 (1992).
    Article CAS Google Scholar
19. Takamiya, Y., Brem, H., Ojeifo, J., Mineta, T. & Martuza, R.L. AGM-1470 inhibits the growth of human glioblastoma Cells in vitro and in vivo. Neurosurgery 34, 869–875 (1994).
    CAS PubMed Google Scholar
20. Holmgren, L., O'Reilly, M.S. & Folkman, J. Dormancy of micrometastases: Balanced proliferation and apoptosis in the presence of angiogenesis suppression. Nature Med. 1, 149–153 (1995).
    Article CAS PubMed Google Scholar
21. Alon, T. et al. Vascular endothelial growth factor acts as a survival factor for newly formed retinal vessels and has implications for retinopathy of prematurity. Nature Med. 1, 1024–1028 (1995).
    Article CAS PubMed Google Scholar
22. Hamada, J., Cavanaugh, P.G., Lotan, O. & Nicolson, G.L. Separable growth and migration factors for large Cell lymphoma Cells secreted by microvascular endothelial Cells derived from target organs for metastasis. Br. J. Cancer 66, 349–354 (1992).
    Article CAS PubMed PubMed Central Google Scholar
23. Graeber, G.G. et al. Hypoxia-mediated selection of Cells with diminished apoptotic potential in solid tumors. Nature 379, 88–91 (1996).
    Article CAS PubMed Google Scholar
24. Fine, H.A. Prospects for gene therapy as an innovative approach to malignant gliomas. Perspect. Neural. Surg. 5, 115–127 (1994).
    Google Scholar
25. Chen, S.-H., Shine, H.D., Goodman, J.C. Grossman, R.G. & Woo, S.L.C. Gene therapy for brain tumor: Regression of experimental gliomas by adenovirus-mediated gene transfer in vivo. Proc. Natl. Acad. Sci. USA 91, 3054–3057 (1994).
    Article CAS PubMed PubMed Central Google Scholar
26. Dong, Y. et al. In vivo replication-deficient adenovirus vector-mediated transduction of the cytosine deaminase gene sensitizes glioma Cells to 5-fluorocytosine. Hum. Cene Ther. 7, 713–720 (1996).
    Article CAS Google Scholar
27. Hochberg, F.H. & Pruitt, A. Assumptions in the radiotherapy of glioblastomas. Neurology 30, 907–991 (1980).
    Article CAS PubMed Google Scholar
28. McGrory, W.J., Bautista, D.S. & Graham, F.L. A simple technique for the rescue of early region 1 mutations into infectious human adenovirus type 5. Virology 163, 614–617 (1988).
    Article CAS PubMed Google Scholar
29. Graham, F.L., Smiley, J., Russel, W.C., St Nairn, R. Characteristics of a human Cell line transformed by DNA from human adenovirus type 5. J. Gen. Virol. 36, 59–72 (1977).
    Article CAS PubMed Google Scholar
30. Takamiya, Y., Friedlander, R.M., Brem, H., Malick, A. & Martuza, R.L. Inhibition of angiogenesis and growth of human nerve-sheath tumors by AGM-1470. J. Neurosurg. 78, 470–476 (1993).
    Article CAS PubMed Google Scholar

Download references