Subcutaneous injection of a cyclic peptide antagonist of vitronectin receptor–type integrins inhibits retinal neovascularization (original) (raw)
References
Prost, M. Experimental studies on the pathogensis of retinopathy of prematurity. Br. J. Ophthalmol.72, 363–367 (1988). ArticleCAS Google Scholar
Thylefors, B., Negrel, A.D., Pararajasegaram, R. & Dadzie, K.Y. Global data on blindness. Bull. World. Health. Organ.73, 115–121 (1995). CASPubMedPubMed Central Google Scholar
Moss, S.E., Klein, R. & Klein, B.E. Ten-year incidence of visual loss in a diabetic population. Ophthalmology101, 1061–1070 (1994). ArticleCAS Google Scholar
The Diabetic retinopathy Study Group. Photocoagulation treatment of proliferative diabetic retinopathy. Clinical application of DRS findings. Ophthalmology88, 583–600 (1981).
Stone, J. et al. Development of retinal vasculature is mediated by hypoxia-induced vascular endothelial growth factor (VEGF) expression by neuroglia. J. Neurosci.15, 4738–4747 (1995). ArticleCAS Google Scholar
Peèr, J. et al. Hypoxia-induced expression of vascular endothelial growth factor by retinal cells is a common factor in neovascularizing ocular diseases. Lab. Invest.72, 638–645 (1995). Google Scholar
Bischoff, J. Approaches to studying cell adhesion molecules in angiogenesis. Trends Cell Biol.5, 69–74 (1995). ArticleCAS Google Scholar
Bacharach, E., Itin, A. & Keshet, E. In vivo patterns of expression of urokinase and its inhibitor PAI-1 suggest a concerted role in regulating physiological angiogenesis. Proc. Natl. Acad. Sci. USA89, 10686–10690 (1992). ArticleCAS Google Scholar
Pierce, E.A., Avery, R.L., Foley, E.D., Aiello, L.P. & Smith, L.E.H. Vascular endothelial growth factor/vascular permeability factor expression in a mouse model of retinal neovascularization. Proc. Natl. Acad. Sci. USA92, 905–909 (1995). ArticleCAS Google Scholar
Pfeiffer, A. & Schatz, H. Diabetic microvascular complications and growth factors. Exp. Clin. Endocrinol. Diabetes103, 7–14 (1995). ArticleCAS Google Scholar
Berka, J.L. et al. Renin-containing Mueller cells of the retina display endocrine features. Invest. Ophthalmol. Vis. Sci.36, 1450–1458 (1995). CASPubMed Google Scholar
Robbins, S.G. et al. Platelet-derived growth factor ligands and receptors immunolocalized in proliferative retinal diseases. Invest. Ophthalmol. Vis. Sci.35, 3649–3663 (1994). CASPubMed Google Scholar
Spranger, J., Meyer-Schwickerath, R., Klein, M., Schatz, H. & Pfeiffer, A. TNF-α level in the vitreous body: Increase in neovascular eye diseases and proliferative diabetic retinopathy. Med. Klin.90, 134–137 (1995). CAS Google Scholar
Leavesley, D.I., Ferguson, G.D., Wayner, E.A. & Cheresh, D.A. Requirement of the integrin β3 subunit for carcinoma cell spreading or migration on vitronectin and fibrinogen. J. Cell Biol.117, 1101–1107 (1992). ArticleCAS Google Scholar
Felding-Habermann, B. & Cheresh, D.A. Vitronectin and its receptors. Curt. Opin. Cell Biol.5, 864–868 (1993). ArticleCAS Google Scholar
Brooks, P.C., Clark, R.A.F. & Cheresh, D.A. Requirement of vascular integrin αvβ3 for angiogenesis. Science264, 569–571 (1994). ArticleCAS Google Scholar
Casaroli Marano, R.P. & Vilaro, S. The role of fibronectin, laminin, vitronectin and their receptors on cellular adhesion in proliferative vitreoretinopathy. Invest. Ophthalmol. Vis. Sci.35, 2791–2903 (1994). CASPubMed Google Scholar
Casaroli Marano, R.P., Preissner, K.T. & Vilaro, S., Fibronectin, laminin, vitronectin and their receptors at newly-formed capillaries in proliferative diabetic retinopathy. Exp. Eye Res.60, 5–17 (1995). ArticleCAS Google Scholar
Brooks, P.C. et al. Integrin αvβ3 antagonists promote tumor regression by inducing apoptosis of angiogenic blood vessels. Cell79, 1157–1164 (1994). ArticleCAS Google Scholar
Friedlander, M. et al. Definition of two angiogenic pathways by distinct αv integrins. Science270, 1500–1502 (1995). ArticleCAS Google Scholar
Millauer, B., Shawver, L.K., Plate, K.H., Risau, W. & Ullrich, A. Glioblastoma growth inhibited in vivo by a dominant-negative Flk-1 mutant. Nature367, 576–579 (1994). ArticleCAS Google Scholar
Smith, L.E.H. et al. Vascular endothelial growth factor/vascular permeability factor is temporally and spatially correlated with ocular angiogenesis in a primate model. Invest. Ophthalmol. Vis. Sci.35, 101–111 (1994). CASPubMed Google Scholar
Aumailley, M. et al. Arg-Gly-Asp constrained within cyclic pentapeptides: Strong and selective inhibitors of cell adhesion to vitronectin and laminin fragment P1. FEBS Lett.291, 50–54 (1991). ArticleCAS Google Scholar
Sasisekharan, R., Moses, M.A., Nugent, M.A., Cooney, C.L. & Langer, R. Heparinase inhibits neovascularization. Proc. Natl. Acad. Sci. USA91, 1524–1528 (1994). ArticleCAS Google Scholar
Iruela-Arispe, M.L., Bornstein, P. & Sage, H. Thrombospondin exerts an anti-angiogenic effect on cord formation by endothelial cells in vitro. Proc. Natl. Acad. Sci. USA88, 5026–5030 (1991). ArticleCAS Google Scholar
Dameron, K.M., Volpert, O.V., Tainsky, M.A. & Bouck, N. Control of angiogenesis in fibroblasts by p53 regulation of thrombospondin-1. Science265, 1582–1584 (1994). ArticleCAS Google Scholar
Moses, M.A., Sudhalter, J. & Langer, R. Identification of an inhibitor of neovascularization from cartilage. Science248, 1408–1410 (1990). ArticleCAS Google Scholar
Johnson, M.D. et al. Inhibition of angiogenesis by tissue inhibitor of metalloproteinase. J. Cell. Physiol.160, 194–202 (1994). ArticleCAS Google Scholar
O'Reilly, M.S. et al. Angiostatin: a novel angiogenesis inhibitor that mediates the suppression of metastases by a Lewis lung carcinoma. Cell79, 315–328 (1994). ArticleCAS Google Scholar
Aiello, L.P. et al. Vascular endothelial growth factor in ocular fluid of patients with diabetic retinopathy and other retinal disorders. N. Engl. J. Med.331, 1480–1487 (1994). ArticleCAS Google Scholar
Jonczyk, A. et al. Zyklische Adhäsionsinhibitoren. EP 0 632 053 (1993).
Preissner, K.T., Anders, E., Grulich-Henn, J. & Müller-Berghaus, G. Attachment of cultured human endothelial cells is promoted by specific association with S protein (vitronectin) as well as with the ternary S protein-thrombin-antithrombin III complex. Blood71, 1581–1589 (1988). CASPubMed Google Scholar