- Lane, H.C. et al. Qualitative analysis of immune function in patients with the acquired immunodeficiency syndrome. N. Engl. J. Med. 313, 79–84 (1985).
Article CAS Google Scholar
- Miedema, F. et al. Immunological abnormalities in human immunodeficiency virus (HIV)-infected asymptomatic homosexual men: HIV affects the immune system before CD4+ T cell depletion occurs. J. Clin. Invest. 82, 1908–1914 (1988).
Article CAS Google Scholar
- Clerici, M. et al. Detection of three distinct patterns of T helper cell dysfunction in asymptomatic, human immunodeficiency virus-seropositive patients. J. Clin. Invest. 84, 1892–1899 (1989).
Article CAS Google Scholar
- Lucey, D.R. et al. Human immunodeficiency virus infection in the US Air Force: Seroconversions, clinical staging and assessment of T helper cell functional assay to predict change in CD4+ T cell counts. J Infect. Dis. 164, 631–637 (1991).
Article CAS Google Scholar
- Gray, D. Immunological memory. Annu. Rev. Immunol. 11, 49–77 (1993).
Article CAS Google Scholar
- Zinkernagel, R.M. The role of antigen in maintaining T cell memory. Dev Biol, Stand. 82, 189–191 (1994).
CAS Google Scholar
- Sanders, M.E. et al. Human memory T lymphocytes express increased levels of three cell adhesion molecules (LFA-3, CD2, and LFA-1) and three other molecules (UCHL1, CDw29, and Pgp-1) and have enhanced IFN-gamma production. J. Immunol. 140, 1401–1407 (1988).
CAS PubMed Google Scholar
- Salmon, M., Kitas, C.D. & Bacon, P.A. Production of lymphokine mRNA by CD45R+ and CD45R- helper T cells from human peripheral blood and by human CD4+ T cell clones. J. Immunol. 143, 907–912 (1989).
CAS PubMed Google Scholar
- Sprent, J. & Tough, D.F. Lymphocyte life-span and memory. Science 265, 1395–1400 (1994).
Article CAS Google Scholar
- Tough, D.F. & Sprent, J. Turnover of naive- and memory-phenotype T cells. J. Exp. Med. 179, 1127–1135 (1994).
Article CAS Google Scholar
- Beverley, P.C. Functional analysis of human T cell subsets defined by CD45 isoform expression. Semin. Immunol. 4, 35–41 (1992).
CAS PubMed Google Scholar
- Mclean, A.R. & Michie, C.A. In vivo estimates of division and death rates of human T lymphocytes. Proc. Natl. Acad. Sci. USA 92, 3707–3711 (1995).
Article CAS Google Scholar
- Trowbridge, I.S. & Thomas, M.L. CD45: An emerging role as a protein tyrosine phosphatase required for lymphocyte activation and development. Annu. Rev. Immunol. 12, 85–116 (1994).
Article CAS Google Scholar
- Sprent, J. Lifespans of naive, memory and effector lymphocytes. Curr. Opin. Immunol. 5, 433–438 (1993).
Article CAS Google Scholar
- Mackall, C.L. et al. Age, thymopoiesis, and CD4+ T-lymphocyte regeneration after intensive chemotherapy. N. Engl. J. Med. 332 143–149 (1995).
Article CAS Google Scholar
- Steis, R.C. et al. Kinetics of recovery of CD4+ T cells in peripheral blood of deoxycoformycin-treated patients. J Natl. Cancer Inst. 83 1678–1679 (1991).
Article CAS Google Scholar
- Puisieux, I. et al. Oligoclonality of tumor-infiltrating lymphocytes from human melanomas. J. Immunol. 153, 2807–2818 (1994).
CAS PubMed Google Scholar
- Gulwani-Akolkar, B. et al. T cell receptor V-segment frequencies in peripheral blood T cells correlate with human leukocyte antigen type. J. Exp. Med. 174, 1139–1146 (1991).
Article CAS Google Scholar
- Cibotti, R. et al. Public and private Vβ T cell receptor repertoires against hen egg white lysozyme (HEL) in nontransgenic versus HEL transgenic mice. J. Exp. Med. 180, 861–872 (1994).
Article CAS Google Scholar
- Cochet, M. et al. Molecular detection and in vivo analysis of the specific T cell response to a protein antigen. Eur. J. Immunol. 22, 2639–2647 (1992).
Article CAS Google Scholar
- Kovacs, J.A. et al. Controlled trial of interleukin-2 infusions in patients infected with the human immunodeficiency virus. N. Engl. J. Med. 335, 1350–1356 (1996).
Article CAS Google Scholar
- Chou, C.C. et al. Phenotypically defined memory CD4+ cells are not selectively decreased in chronic HIV disease. J. Acquir. Immune Defic. Syndr. 7, 665–675 (1994).
CAS PubMed Google Scholar
- Roederer, M. et al. CD8 naive T cell counts decrease progressively in HIV-infected adults. J. Clin. Invest. 95, 2061–2066 (1995).
Article CAS Google Scholar
- Rabin, R.L. et al. Altered representation of naive and memory CD8 T cell subsets in HIV-infected children. J. Clin. Invest. 95, 2054–2060 (1995).
Article CAS Google Scholar
- Schnittman, S.M. et al. Preferential infection of CD4+ memory T cells by human immunodeficiency virus type 1: Evidence for a role in the selective T-cell functional defects observed in infected individuals. Proc. Natl. Acad. Sci. USA 87, 6058–6062 (1990).
Article CAS Google Scholar
- Stanley, S.K. et al. Human immunodeficiency virus infection of the human thymus and disruption of the thymic microenvironment in the SCID-hu mouse. J. Exp. Med. 178, 1151–1163 (1993).
Article CAS Google Scholar
- Imberti, L., Sottini, A., Bettinardi, A., Puoti, M., & Primi, D., Selective depletion in HIV infection of T cells that bear specific T cell receptor Vβ sequences. Science 254, 860–862 (1991).
Article CAS Google Scholar
- Laurence, J., Hodtsev, A.S. & Posnett, D.N. Superantigen implicated in dependence of HIV-1 replication in T cells on TCR Vβ expression. Nature 358, 255–259 (1992).
Article CAS Google Scholar
- Rebai, N. et al. Analysis of the T cell receptor β-chain variable-region (TCRBV) repertoire in monozygotic twins discordant for human immunodeficiency virus: Evidence for perturbations of specific Vβ segments in CD4+ T cells of the virus-positive twins. Proc. Natl. Acad. Sci. USA 91, 1529–1533 (1994).
Article CAS Google Scholar
- Westby, M., Manca, F. & Dalgleish, A.G. The role of host immune responses in determining the outcome of HIV infection. Immunol. Today 17, 120–126 (1996).
Article CAS Google Scholar
- Dalgleish, A.G. et al. T cell receptor variable gene products and early HIV-1 infection. Lancet 339, 824–828 (1992).
Article CAS Google Scholar
- Dobrescu, D. et al. Human immunodeficiency virus 1 reservoir in CD4+ T cells is restricted to certain Vb subsets. Proc. Natl. Acad. Sci. USA 92, 5563–5567 (1995).
Article CAS Google Scholar
- Dobrescu, D., Ursea, B., Pope, M., Asch, A.S. & Posnett, D.N. Enhanced HIV-1 replication in Vβ12 T cells due to human cytomegalovirus in monocytes: Evidence for a putative herpesvirus superantigen. Cell 82, 753–763 (1995).
Article CAS Google Scholar
- Soudeyns, H. et al. The T cell receptor Vβ repertoire in HIV-1 infection and disease. Semin. Immunol. 5, 175–185 (1993).
Article CAS Google Scholar
- Condra, J.H. et al. In vivo emergence of HIV-1 variants resistant to multiple protease inhibitors. Nature 374, 569–571 (1995).
Article CAS Google Scholar
- Centers for Disease Control and Prevention, 1994 revised guidelines for the performance of CD4+ T-cell determinations in persons with human immunodeficiency virus (HIV) infections. MMWR Morbid. Mortal. Wkly. Rep. 43, 1–21 (1994).
- Genevee, C. et al. An experimentally validated panel of subfamily-specific oligonucleotide primers (Vαl-w29/Vβ1-w24) for the study of human T cell receptor variable V gene segment usage by polymerase chain reaction. Eur. J. Immunol. 22, 1261–1269 (1992).
Article CAS Google Scholar
- Arden, B., Clark, S.P., Kabelitz, D. & Mak, T.W. T-cell receptor variable gene segment families. Immunogenetics 42, 455–500 (1995).
CAS PubMed Google Scholar
- Choi, Y. et al. Interaction of Staphylococcus aureus toxin “superantigens” with human T ceils. Proc. Natl. Acad. Sci. USA 86, 8941–8945 (1989).
Article CAS Google Scholar
- Arden, B., Clark, S.P., Kabelitz, D. & Mak, T.W. Human T-cell receptor variable gene segment families. Immunogenetics 42, 455–500 (1995).
CAS PubMed Google Scholar
- Pannetier, C. et al. The sizes of the CDR3 hypervariable regions of the murine T cell receptor β chains vary as a function of the recombined germ-line segments. Proc. Natl. Acad. Sci. USA 90, 4319–4323 (1993).
Article CAS Google Scholar