A suicide note from Alzheimer disease neurons? (original) (raw)
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- Published: 01 August 1998
Nature Medicine volume 4, pages 897–898 (1998)Cite this article
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New findings implicate apoptosis in the death of neurons in Alzheimer disease but the evidence is still insufficient to formally indict apoptosis in the neurodegeneration associated with this disease (pages 957–962).
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References
- Guo, Q. et al. Par-4 is a novel mediator of neuronal degeneration associated with the pathogenesis of Alzheimer disease. Nature Med. 4, 957–962 (1998).
Article CAS Google Scholar - Cotman, C.W. & Su, J.H. Mechanisms of neuronal death in Alzheimer's disease. Brain Pathol. 6, 493–506 (1996).
Article CAS Google Scholar - Tsang, S.Y., Tam, S.C., Bremner, I. & Burkitt, M.J. Copper-1,10-phenanthroline induces internucleosomal DNA fragmentation in HepG2 cells, resulting from direct oxidation by the hydroxyl radical. Biochem. J. 317, 13–16 (1996).
Article CAS Google Scholar - Stadelmann, C., Brück, W., Bancher, C., Jellinger, K. & Lassmann, H. Alzheimer disease: DNA fragmentation indicates increased neuronal vulnerability, but not apoptosis. J. Neuropathol. Exp. Neural. 57, 456–464 (1998).
Article CAS Google Scholar - Su, J.H., Deng, G. & Cotman, C.W. Neuronal DNA damage precedes tangle formation and is associated with up-regulation of nitrotyrosine in Alzheimer's disease brain. Brain Res. 774, 193–199 (1997).
Article CAS Google Scholar - Smith, M.A. et al. Oxidative damage in Alzheimer's disease. Nature 382, 120–121 (1996).
Article CAS Google Scholar - Irizarry, M.C., McNamara, M., Fedorchak, K., Hsiao, K. & Hyman, B.T. APPSw trangenic mice develop age-related Aβ deposits and neuropil abnormalities, but no neuronal loss in CA1. J. Neuropathol. Exp. Neural. 56, 965–973 (1997).
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Authors and Affiliations
- Institute of Pathology, Case Western Reserve University, Cleveland, Ohio, 44106, USA
George Perry, Akihiko Nunomura & Mark A. Smith
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- George Perry
You can also search for this author inPubMed Google Scholar - Akihiko Nunomura
You can also search for this author inPubMed Google Scholar - Mark A. Smith
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Perry, G., Nunomura, A. & Smith, M. A suicide note from Alzheimer disease neurons?.Nat Med 4, 897–898 (1998). https://doi.org/10.1038/nm0898-897
- Issue Date: 01 August 1998
- DOI: https://doi.org/10.1038/nm0898-897
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