The cultural mouse (original) (raw)

• Stevens, L.C. The biology of teratomas. Adv. Morphog. 6, 1–31 (1967).
  Article CAS Google Scholar
• Pierce, G.B. Teratocarcinoma: Model for a developmental concept of cancer. Curr. Topics Dev. Biol. 2, 223–246 (1967).
  Article CAS Google Scholar
• Kleinsmith, L.J. & Pierce, G.B. Multipotentiality of single embryonal carcinoma cells. Cancer Res. 24, 1544–1551 (1964).
  CAS PubMed Google Scholar
• Evans, M.J. The isolation and properties of a clonal tissue culture strain of pluripotent mouse teratocarcinoma cells. J. Embryol. Exp. Morphol. 28, 163–196 (1972).
  CAS PubMed Google Scholar
• Evans, M.J. & Martin, G.R. The differentiation of clonal teratocarcinoma cell culture in vitro. In Roche Symposium on Teratomas and Differentiation (eds. Solter, D. & Sherman, M.) (Academic Press, New York, 1975).
• Martin, G.R & Evans, M.J. Differentiation of clonal lines of teratocarcinoma cells: formation of embryoid bodies in vitro. Proc. Natl. Acad. Sci. USA 72, 1441–1445, (1975).
  Article CAS Google Scholar
• Papaioannou, V.E., McBurney, M., Gardner, R.L. & Evans, M.J. The fate of teratocarcinoma cells injected into early mouse embryos. Nature 258, 70–73 (1975).
  Article CAS Google Scholar
• Gooi, H.C. et al. Stage-specific embryonic antigen involves 1-3 fucosylated type 2 blood group chains. Nature 292, 156–158 (1981).
  Article CAS Google Scholar
• Stinnakre, M.G., Evans, M.J., Willison, K.R. & Stern, P.L. Expression of Forssman antigen in the post-implantation mouse embryo. J. Embryol. Exp. Morphol. 61, 117–131 (1981).
  CAS PubMed Google Scholar
• Lovell-Badge, R.H. & Evans, M.J. Changes in protein synthesis during differentiation of embryonal carcinoma cells and a comparison with embryo cells. J. Embryol. Exp. Morphol. 59, 187–206 (1980).
  CAS PubMed Google Scholar
• Evans, M.J. Origin of mouse embryonal carcinoma cells and the possibility of their direct isolation into tissue culture. J. Reprod. Fertil. 62, 625–631 (1981).
  Article CAS Google Scholar
• Evans, M.J. & Kaufman, M.H. Establishment in culture of pluripotential cells from mouse embryos. Nature 292, 154–156 (1981).
  Article CAS Google Scholar
• Rastan, S. & Robertson, E.J. X-chromosome deletions in embryo-derived (EK) cell-lines associated with lack of X-chromosome inactivation. J. Embryol. Exp. Morph. 90, 379–388 (1985).
  CAS PubMed Google Scholar
• Evans, M.J., Bradley, A. & Robertson, E.J. EK cell contribution to chimeric mice: from tissue culture to sperm. In Genetic Manipulation of the Early Mammalian Embryo, Banbury Report. (Cold Spring Harbor Laboratory Press, Plainview, NY, 1983).
  Google Scholar
• Bradley, A., Evans, M.J., Kaufman, M.H. & Robertson, E.J. Formation of germ-line chimaeras from embryo-derived teratocarcinoma cell lines. Nature 309, 255–256 (1984).
  Article CAS Google Scholar
• Mann, R., Mulligan, R.C. & Baltimore, D. Construction of a retrovirus packaging mutant and its use to produce helper-free defective retrovirus. Cell 33, 153–159 (1983).
  Article CAS Google Scholar
• Kuehn, M.R., Bradley, A., Robertson, E.J. & Evans, M.J. A potential animal model for Lesch-Nyhan syndrome through introduction of HPRT mutations into mice. Nature 326, 295–298 (1987).
  Article CAS Google Scholar
• Smithies, O., Gregg, R.G., Boggs, S.S., Koralewski, M.A. & Kucherlapati, R.S. Insertion of DNA sequences into the human chromosomal b-globin locus by homologous recombination. Nature 317, 230–234 (1985).
  Article CAS Google Scholar
• Smithies, O. Zone electrophoresis in starch gels: Group variations in the serum proteins of normal human adults. Biochem. J. 61, 629–641 (1955).
  Article CAS Google Scholar
• Smithies, O. & Walker, N.F. Genetic control of some serum proteins in normal humans. Nature 176, 1265–1266 (1955).
  Article CAS Google Scholar
• Sturtevant, A.H. The effects of unequal crossing over at the Bar locus in Drosophila. Genetics 10, 117–147 (1925).
  CAS PubMed PubMed Central Google Scholar
• Smithies, O., Connell, G.E. & Dixon, G.H. Chromosomal rearrangements and the evolution of haptoglobin genes. Nature 196, 232–236 (1962).
  Article CAS Google Scholar
• Smithies, O. Antibody variability. Science 157, 267–273 (1967).
  Article CAS Google Scholar
• Slightom, J.L., Blechl, A.E. & Smithies, O. Human fetal Gg and Ag globin genes: Complete nucleotide sequences suggest that DNA can be exchanged between these duplicated genes. Cell 21, 627–638 (1980).
  Article CAS Google Scholar
• Goldfarb, M., Shimizu, K., Perucho, M. & Wigler, M. Isolation and preliminary characterization of a human transforming gene from T24 bladder carcinoma cells. Nature 296, 404–409 (1982).
  Article CAS Google Scholar
• Smithies, O. A Dynamic osmometer for accurate measurements on small quantities of material: Osmotic pressures of isoelectric b-lactoglobulin solutions. Biochem. J. 55, 57–67 (1953).
  Article CAS Google Scholar
• Kim, H.S. & Smithies, O. Recombinant fragment assay for gene targetting based on the polymerase chain reaction. Nucleic Acids Res. 16, 8887–8903 (1988).
  Article CAS Google Scholar
• Doetschman, T. et al. Targetted correction of a mutant HPRT gene in mouse embryonic stem cells. Nature 330, 576–578 (1987).
  Article CAS Google Scholar
• Koller, B.H. et al. Germ-line transmission of a planned alteration made in a hypoxanthine phosphoribosyltransferase gene by homologous recombination in embryonic stem cell. Proc. Natl. Acad. Sci. USA 86, 8927–8931 (1989).
  Article CAS Google Scholar
• Smithies, O. & Maeda, N. Gene targeting approaches to complex genetic diseases: Atherosclerosis and essential hypertension. Proc. Natl. Acad. Sci. USA 92, 5266–5272 (1995).
  Article CAS Google Scholar
• Kim, H.-S. et al. Genetic control of blood pressure and the angiotensinogen locus. Proc. Natl. Acad. Sci. USA 92, 2735–2739 (1995).
  Article CAS Google Scholar
• Capecchi, M.R. Targeted gene replacement. Sci. Am. 270, 54–61 (1994).
  Article Google Scholar
• Wigler, M. et al. Transfer of purified Herpes Virus thymidine kinase gene to cultured mouse cells. Cell 11, 223–232 (1977).
  Article CAS Google Scholar
• Capecchi, M.R. High efficiency transformation by direct microinjection of DNA into cultured mammalian cells. Cell 22, 479–488 (1980).
  Article CAS Google Scholar
• Gordon, J.W., Scangos, G.A., Plotkin, D.J., Barbosa, J.A. & Ruddle, F.H. Genetic transformation of mouse embryos by microinjection of purified DNA. Proc. Natl. Acad. Sci. USA 77, 7380–7384 (1980).
  Article CAS Google Scholar
• Costantini, F. & Lacy, E. Introduction of a rabbit b-globin gene into the mouse germ line. Nature 294, 92–94 (1981).
  Article CAS Google Scholar
• Brinster, R.L. et al. Somatic expression of herpes thymidine kinase in mice following injection of a fusion gene into eggs. Cell 27, 223–231 (1981).
  Article CAS Google Scholar
• Wagner, E.F., Stewart, T.A. & Mintz, B. The human b globin gene and a functional thymidine kinase gene in developing mice. Proc. Natl. Acad. Sci. USA 78, 5016–5020 (1981).
  Article CAS Google Scholar
• Wagner, T.E. et al. Microinjection of a rabbit b-globin gene in zygotes and its subsequent expression in adult mice and their offspring. Proc. Natl. Acad. Sci. USA 78, 6376–6380 (1981).
  Article CAS Google Scholar
• Levinson, B., Khoury, B.G., VandeWoude, G. & Gruss, P. Activation of SV40 genome by 72-base pair tandem repeats of Moloney sarcoma virus. Nature 295, 568–572 (1982).
  Article CAS Google Scholar
• Folger, K.R., Wong, E.A., Wahl, G. & Capecchi, M.R. Patterns of integration of DNA microinjected into cultured mammalian cells: Evidence for homologous recombination between injected plasmid DNA molecules. Mol. Cell. Biol. 2, 1372–1387 (1982).
  Article CAS Google Scholar
• Folger, K.R., Thomas, K.R. & Capecchi, M.R. Nonreciprocal exchanges of information between DNA duplexes coinjected into mammalian cell nuclei. Mol. Cell. Biol. 5, 59–69 (1985).
  Article CAS Google Scholar
• Wong, E.A. & Capecchi, M.R. Homologous recombination between coinjected DNA sequences peaks in early to mid-S phase. Mol. Cell. Biol. 7, 2294–2295 (1987).
  Article CAS Google Scholar
• Thomas, K.R., Folger, K.R. & Capecchi, M.R. High frequency targeting of genes to specific sites in the mammalian genome. Cell 44, 419–428 (1986).
  Article CAS Google Scholar
• Folger, K.R., Thomas, K.R. & M.R. Capecchi . Analysis of homologous recombination in cultured mammalian cells. Cold Spring Harbor Symp. Quant. Biol. 49, 123–138 (1984).
  Article CAS Google Scholar
• Thomas, K.R. & Capecchi, M.R. Site-directed mutagenesis by gene targeting in mouse embryo-derived stem cells. Cell 51, 503–512 (1987).
  Article CAS Google Scholar
• Thomas, K.R., Deng, C. & Capecchi, M.R. High-fidelity gene targeting in embryonic stem cells by using sequence replacement vectors. Mol. Cell. Biol. 12, 2919–2923 (1992).
  Article CAS Google Scholar
• Deng, C. & Capecchi, M.R. Reexamination of gene targeting frequency as a function of the extent of homology between the targeting vector and the target locus. Mol. Cell. Biol. 12, 3365–3371 (1992).
  Article CAS Google Scholar
• Deng, C., Thomas, K.R. & Capecchi, M.R. Location of crossovers during gene targeting with insertion and replacement vectors. Mol. Cell. Biol. 13, 2134–2140 (1993).
  Article CAS Google Scholar
• Mansour, S.L., Thomas, K.R. & Capecchi, M.R. Disruption of the proto-oncogene int-2 in mouse embryo-derived stem cells: a general strategy for targeting mutations to non-selectable genes. Nature 336, 348–352 (1988).
  Article CAS Google Scholar
• Gu, H., Marth, J.D., Orban, P.C., Mossmann, H. & Rajewsky, K. Deletion of a DNA polymerase beta gene segment in T cells using cell type-specific gene targeting. Science 265, 103–106 (1994).
  Article CAS Google Scholar