Ferredoxin reductase affects p53-dependent, 5-fluorouracil–induced apoptosis in colorectal cancer cells (original) (raw)

References

  1. O'Connor, P.M. et al. Characterization of the p53 tumor suppressor pathway in cell lines of the National Cancer Institute anticancer drug screen and correlations with the growth-inhibitory potency of 123 anticancer agents. Cancer Res. 57, 4285–300 (1997).
    CAS PubMed Google Scholar
  2. Lowe, S.W. et al. p53 status and the efficacy of cancer therapy in vivo. Science 266, 807–810 (1994).
    Article CAS Google Scholar
  3. Bunz, F. et al. Disruption of p53 in human cancer cells alters the responses to therapeutic agents. J. Clin. Invest. 104, 263–269 (1999).
    Article CAS Google Scholar
  4. Oren, M. Regulation of the p53 tumor suppressor protein. J. Biol. Chem. 274, 36031–36034 (1999).
    Article CAS Google Scholar
  5. Prives, C. & Hall, P.A. The p53 pathway. J. Pathol. 187, 112–126 (1999).
    Article CAS Google Scholar
  6. El-Deiry, W.S. Regulation of p53 downstream genes. Semin. Cancer Biol. 8, 345–357 (1998).
    Article CAS Google Scholar
  7. Giaccia, A.J. & Kastan, M.B. The complexity of p53 modulation: emerging patterns from divergent signals. Genes Dev. 12, 2973–2983 (1998).
    Article CAS Google Scholar
  8. Johnson, T.M., Yu, Z.-X., Ferrans, V.J., Lowenstein, R.A. & Finkel, T. Reactive oxygen species are downstream mediators of p53-dependent apoptosis. Proc. Natl. Acad. Sci. USA 93, 11848–11852 (1996).
    Article CAS Google Scholar
  9. Polyak, K., Xia, Y., Zweier, J.L., Kinzler, K.W. & Vogelstein, B. A model for p53 induced apoptosis. Nature 389, 300–304 (1997).
    Article CAS Google Scholar
  10. Lee, J.M. Inhibition of p53-dependent apoptosis by the KIT tyrosine kinase: regulation of mitochondrial permeability transition and reactive oxygen species generation. Oncogene 17, 1653–1662 (1998).
    Article CAS Google Scholar
  11. Li, P.F., Dietz, R. & von Harsdorf, R. p53 regulates mitochondrial membrane potential through reactive oxygen species and induces cytochrome c-independent apoptosis blocked by Bcl-2. EMBO J. 18, 6027–6036 (1999).
    Article CAS Google Scholar
  12. Green, D.R. & Reed, J.C. Mitochondria and apoptosis. Science 281, 1309–12 (1998).
    Article CAS Google Scholar
  13. Kroemer, G. & Reed, J.C. Mitochondrial control of cell death. Nature Med 6, 513–519 (2000).
    Article CAS Google Scholar
  14. Velculescu, V.E., Zhang, L., Vogelstein, B. & Kinzler, K.W. Serial Analysis Of Gene Expression. Science 270, 484–487 (1995).
    Article CAS Google Scholar
  15. El-Deiry, W.S., Kern, S.E., Pietenpol, J.A., Kinzler, K.W. & Vogelstein, B. Definition of a consensus binding site for p53. Nature Genet. 1, 45–49 (1992).
    Article CAS Google Scholar
  16. Lambeth, J.D., Seybert, D.W., Lancaster, J.R., Salerno, J.C. & Kamin, H. Steroidogenic electron transport in adrenal cortex mitochondria. Mol. Cell. Biochem. 45, 13–31 (1982).
    Article CAS Google Scholar
  17. Lin, D., Shi, Y.F. & Miller, W.L. Cloning and sequence of the human adrenodoxin reductase gene. Proc. Natl. Acad. Sci. USA 87, 8516–8520 (1990).
    Article CAS Google Scholar
  18. Ziegler, G.A., Vonrhein, C., Hanukoglu, I. & Schulz, G.E. The structure of adrenodoxin reductase of mitochondrial P450 systems: electron transfer for steroid biosynthesis. J. Mol. Biol. 289, 981–990 (1999).
    Article CAS Google Scholar
  19. Rapoport, R., Sklan, D. & Hanukoglu, I. Electron leakage from the adrenal cortex mitochondrial P450scc and P450c11 systems: NADPH and steroid dependence. Arch. Biochem. Biophys. 317, 412–416 (1995).
    Article CAS Google Scholar
  20. Hanukoglu, I., Rapoport, R., Weiner, L. & Sklan, D. Electron leakage from the mitochondrial NADPH-adrenodoxin reductase- adrenodoxin-P450scc (cholesterol side chain cleavage) system. Arch. Biochem. Biophys. 305, 489–498 (1993).
    Article CAS Google Scholar
  21. Yu, J. et al. Identification and classification of p53-regulated genes. Proc. Natl. Acad. Sci. USA 96, 14517–14522 (1999).
    Article CAS Google Scholar
  22. Chan, T.A., Hermeking, H., Lengauer, C., Kinzler, K.W. & Vogelstein, B. 14-3-3Sigma is required to prevent mitotic catastrophe after DNA damage. Nature 401, 616–620 (1999).
    Article CAS Google Scholar
  23. Masramon, L. et al. Cytogenetic characterization of two colon cell lines by using conventional G-banding, comparative genomic hybridization, and whole chromosome painting. Cancer Genet. Cytogenet. 121, 17–21 (2000).
    Article CAS Google Scholar
  24. Yu, J., Zhang, L., Hwang, P.M., Kinzler, K.W. & Vogelstein, B. PUMA induces the rapid apoptosis of colorectal cancer cells. Molecular Cell 7, 673–682 (2001).
    Article CAS Google Scholar
  25. Bunz, F. et al. Requirement for p53 and p21 to sustain G2 arrest after DNA damage. Science 282, 1497–1501 (1998).
    Article CAS Google Scholar
  26. Pham, N.A., Robinson, B.H. & Hedley, D.W. Simultaneous detection of mitochondrial respiratory chain activity and reactive oxygen in digitonin-permeabilized cells using flow cytometry. Cytometry 41, 245–251 (2000).
    Article CAS Google Scholar
  27. Kelso, G.F. et al. Selective targeting of a redox-active ubiquinone to mitochondria within cells: Antioxidant and antiapoptotic properties. J. Biol. Chem. 276, 4588–4596 (2001).
    Article CAS Google Scholar
  28. Lill, R. & Kispal, G. Maturation of cellular Fe-S proteins: an essential function of mitochondria. Trends Biochem. Sci. 25, 352–356 (2000).
    Article CAS Google Scholar
  29. Manzella, L., Barros, M.H. & Nobrega, F.G. ARH1 of Saccharomyces cerevisiae: A new essential gene that codes for a protein homologous to the human adrenodoxin reductase. Yeast 14, 839–846 (1998).
    Article CAS Google Scholar
  30. Li, J., Saxena, S., Pain, D. & Dancis, A. Adrenodoxin reductase homolog (Arh1p) of yeast mitochondria required for iron homeostasis. J. Biol. Chem. 276, 1503–1509 (2001).
    Article CAS Google Scholar
  31. Vogelstein, B., Lane, D. & Levine, A.J. Surfing the p53 network. Nature 408, 307–310 (2000).
    Article CAS Google Scholar
  32. Asher, G., Lotem, J., Cohen, B., Sachs, L. & Shaul, Y. Regulation of p53 stability and p53-dependent apoptosis by NADH quinone oxidoreductase 1. Proc. Natl. Acad. Sci. USA 98, 1188–1193 (2001).
    Article CAS Google Scholar
  33. Meek, D.W. Mechanisms of switching on p53: a role for covalent modification? Oncogene 18, 7666–7675 (1999).
    Article CAS Google Scholar
  34. Waldman, T., Kinzler, K.W. & Vogelstein, B. p21 is necessary for the p53-mediated G(1) arrest in human cancer cells. Cancer Res. 55, 5187–5190 (1995).
    CAS PubMed Google Scholar
  35. Zhang, L. et al. Gene expression profiles in normal and cancer cells. Science 276, 1268–1272 (1997).
    Article CAS Google Scholar
  36. Feinberg, A.P. & Vogelstein, B. A technique for radiolabeling DNA restriction endonuclease fragments to high specific activity. Anal. Biochem. 132, 6–13 (1983).
    Article CAS Google Scholar
  37. Jallepalli, P.V. et al. Securin is required for chromosomal stability in human cells. Cell 105, 445–457 (2001).
    Article CAS Google Scholar
  38. He, T.C. et al. A simplified system for generating recombinant adenoviruses. Proc. Natl. Acad. Sci. USA 95, 2509–2514 (1998).
    Article CAS Google Scholar
  39. Waldman, T., Lengauer, C., Kinzler, K.W. & Vogelstein, B. Uncoupling of S phase and mitosis induced by anticancer agents in cells lacking p21. Nature 381, 713–716 (1996).
    Article CAS Google Scholar

Download references