Targeted disruption of inducible nitric oxide synthase protects against obesity-linked insulin resistance in muscle (original) (raw)

• Moncada, S. & Higgs, A. The L-arginine-nitric oxide pathway. N. Engl. J. Med. 329, 2002–2012 (1993).
  Article CAS Google Scholar
• Nathan, C. Inducible nitric oxide synthase: what difference does it make? J. Clin. Invest. 100, 2417–23 (1997).
  Article CAS Google Scholar
• Dawson, V.L. & Dawson, T.M. Physiological and toxicological actions of nitric oxide in the central nervous system. Adv. Pharmacol. 34, 323–342 (1995).
  Article CAS Google Scholar
• Parkinson, J.F., Mitrovic, B. & Merrill, J.E. The role of nitric oxide in multiple sclerosis. J. Mol. Med. 75, 174–86 (1997).
  Article CAS Google Scholar
• Stichtenoth, D.O. & Frolich, J.C. Nitric oxide and inflammatory joint diseases. Br. J. Rheumatol. 37, 246–257 (1998).
  Article CAS Google Scholar
• Behr-Roussel, D. et al. Effect of chronic treatment with the inducible nitric oxide synthase inhibitor _N_-iminoethyl-l-lysine or with l-arginine on progression of coronary and aortic atherosclerosis in hypercholesterolemic rabbits. Circulation 102, 1033–1038 (2000).
  Article CAS Google Scholar
• Cromheeke, K.M. et al. Inducible nitric oxide synthase colocalizes with signs of lipid oxidation/peroxidation in human atherosclerotic plaques. Cardiovasc. Res. 43, 744–754 (1999).
  Article CAS Google Scholar
• Shimabukuro, M., Ohneda, M., Lee, Y. & Unger, R.H. Role of nitric oxide in obesity-induced β cell disease. J. Clin. Invest. 100, 290–295 (1997).
  Article CAS Google Scholar
• Shimabukuro, M., Zhou, Y.T., Levi, M. & Unger, R.H. Fatty acid-induced β cell apoptosis: a link between obesity and diabetes. Proc. Natl. Acad. Sci. USA 95, 2498–2502 (1998).
  Article CAS Google Scholar
• Zhou, Y.T. et al. Lipotoxic heart disease in obese rats: implications for human obesity. Proc. Natl. Acad. Sci. USA 97, 1784–9 (2000).
  Article CAS Google Scholar
• Ginsberg, H.N. Insulin resistance and cardiovascular disease. J. Clin. Invest. 106, 453–458 (2000).
  Article CAS Google Scholar
• Grundy, S.M. Hypertriglyceridemia, insulin resistance, and the metabolic syndrome. Am. J. Cardiol. 83, 25F–29F (1999).
  Article CAS Google Scholar
• Shulman, G.I. Cellular mechanisms of insulin resistance in humans. Am. J. Cardiol. 84, 3J–10J (1999).
  Article CAS Google Scholar
• Pickup, J.C. & Crook, M.A. Is type II diabetes mellitus a disease of the innate immune system? Diabetologia 41, 1241–1248 (1998).
  Article CAS Google Scholar
• Hotamisligil, G.S., Arner, P., Caro, J.F., Atkinson, R.L. & Spiegelman, B.M. Increased adipose tissue expression of tumor necrosis factor-α in human obesity and insulin resistance. J. Clin. Invest. 95, 2409–2415 (1995).
  Article CAS Google Scholar
• Yudkin, J.S., Stehouwer, C.D., Emeis, J.J. & Coppack, S.W. C-reactive protein in healthy subjects: associations with obesity, insulin resistance, and endothelial dysfunction: a potential role for cytokines originating from adipose tissue? Arterioscler. Thromb. Vasc. Biol. 19, 972–978 (1999).
  Article CAS Google Scholar
• Hotamisligil, G.S., Shargill, N.S. & Spiegelman, B.M. Adipose expression of tumor necrosis factor-α: direct role in obesity-linked insulin resistance. Science 259, 87–91 (1993).
  Article CAS Google Scholar
• Hotamisligil, G.S. & Spiegelman, B.M. Tumor necrosis factor α: a key component of the obesity-diabetes link. Diabetes 43, 1271–1278 (1994).
  Article CAS Google Scholar
• Hotamisligil, G.S., Murray, D.L., Choy, L.N. & Spiegelman, B.M. Tumor necrosis factor α inhibits signaling from the insulin receptor. Proc. Natl. Acad. Sci. USA 91, 4854–4858 (1994).
  Article CAS Google Scholar
• Hotamisligil, G.S. et al. IRS-1-mediated inhibition of insulin receptor tyrosine kinase activity in TNF–α- and obesity-induced insulin resistance. Science 271, 665–668 (1996).
  Article CAS Google Scholar
• Stephens, J.M., Lee, J. & Pilch, P.F. Tumor necrosis factor-α-induced insulin resistance in 3T3-L1 adipocytes is accompanied by a loss of insulin receptor substrate-1 and GLUT4 expression without a loss of insulin receptor-mediated signal transduction. J. Biol. Chem. 272, 971–976 (1997).
  Article CAS Google Scholar
• Bedard, S., Marcotte, B. & Marette, A. Cytokines modulate glucose transport in skeletal muscle by inducing the expression of inducible nitric oxide synthase. Biochem. J. 325, 487–493 (1997).
  Article CAS Google Scholar
• Kapur, S., Bedard, S., Marcotte, B., Cote, C.H. & Marette, A. Expression of nitric oxide synthase in skeletal muscle: a novel role for nitric oxide as a modulator of insulin action. Diabetes 46, 1691–1700 (1997).
  Article CAS Google Scholar
• Kapur, S., Marcotte, B. & Marette, A. Mechanism of adipose tissue iNOS induction in endotoxemia. Am. J. Physiol. 276, E635–641 (1999).
  CAS PubMed Google Scholar
• Zierath, J.R., Houseknecht, K.L., Gnudi, L. & Kahn, B.B. High-fat feeding impairs insulin-stimulated GLUT4 recruitment via an early insulin-signaling defect. Diabetes 46, 215–223 (1997).
  Article CAS Google Scholar
• Wang, Q. et al. Protein kinase B/Akt participates in GLUT4 translocation by insulin in L6 myoblasts. Mol. Cell Biol. 19, 4008–4018 (1999).
  Article CAS Google Scholar
• Anai, M. et al. Enhanced insulin-stimulated activation of phosphatidylinositol 3-kinase in the liver of high-fat–fed rats. Diabetes 48, 158–169 (1999).
  Article CAS Google Scholar
• Pilon, G., Penfornis, P. & Marette, A. Nitric oxide production by adipocytes: a role in the pathogenesis of insulin resistance? Horm. Metab. Res. 32, 480–484 (2000).
  Article CAS Google Scholar
• Liu, D. et al. Cytokines induce apoptosis in β-cells isolated from mice lacking the inducible isoform of nitric oxide synthase (iNOS−/−). Diabetes 49, 1116–1122 (2000).
  Article CAS Google Scholar
• Despres, J.P. et al. Hyperinsulinemia as an independent risk factor for ischemic heart disease. N. Engl. J. Med. 334, 952–957 (1996).
  Article CAS Google Scholar
• Weyer, C., Hanson, R.L., Tataranni, P.A., Bogardus, C. & Pratley, R.E. A high fasting plasma insulin concentration predicts type 2 diabetes independent of insulin resistance: evidence for a pathogenic role of relative hyperinsulinemia. Diabetes 49, 2094–2101 (2000).
  Article CAS Google Scholar
• Garvey, E.P. et al. 1400W is a slow, tight binding, and highly selective inhibitor of inducible nitric-oxide synthase in vitro and in vivo. J. Biol. Chem. 272, 4959–4963 (1997).
  Article CAS Google Scholar
• McMillan, K. et al. Allosteric inhibitors of inducible nitric oxide synthase dimerization discovered via combinatorial chemistry. Proc. Natl. Acad. Sci. USA 97, 1506–1511 (2000).
  Article CAS Google Scholar
• Saltiel, A.R. & Olefsky, J.M. Thiazolidinediones in the treatment of insulin resistance and type II diabetes. Diabetes 45, 1661–1669 (1996).
  Article CAS Google Scholar
• Kwon, G., Xu, G., Marshall, C.A. & McDaniel, M.L. Tumor necrosis factor α-induced pancreatic β-cell insulin resistance is mediated by nitric oxide and prevented by 15-deoxy-Δ,14-prostaglandin J2 and aminoguanidine. A role for peroxisome proliferator-activated receptor γ activation and inos expression. J. Biol. Chem. 274, 18702–18708 (1999).
  Article CAS Google Scholar
• Li, M., Pascual, G. & Glass, C.K. Peroxisome proliferator-activated receptor γ-dependent repression of the inducible nitric oxide synthase gene. Mol. Cell. Biol. 20, 4699–4707 (2000).
  Article CAS Google Scholar
• Maggi, L.B. Jr et al. Anti-inflammatory actions of 15-deoxy-Δ 12,14-prostaglandin J2 and troglitazone: evidence for heat shock-dependent and -independent inhibition of cytokine-induced inducible nitric oxide synthase expression. Diabetes 49, 346–355 (2000).
  Article CAS Google Scholar
• MacMicking, J.D. et al. Altered responses to bacterial infection and endotoxic shock in mice lacking inducible nitric oxide. Cell 81, 641–50 (1995); erratum: 81, 1170 (1995).
  Article CAS Google Scholar
• Laubach, V.E., Shesely, E.G., Smithies, O. & Sherman, P.A. Mice lacking inducible nitric oxide synthase are not resistant to lipopolysaccharide-induced death. Proc. Natl. Acad. Sci. USA 92, 10688–10692 (1995).
  Article CAS Google Scholar
• Tremblay, F., Lavigne, C., Jacques, H. & Marette, A. Defective insulin-induced glut4 translocation in skeletal muscle of high fat-fed rats is associated with alterations in both akt/protein kinase b and atypical protein kinase c (ζ/λ) activities. Diabetes 50, 1901–1910 (2001).
  Article CAS Google Scholar
• Tesauro, M. et al. Intracellular processing of endothelial nitric oxide synthase isoforms associated with differences in severity of cardiopulmonary diseases: cleavage of proteins with aspartate vs. glutamate at position 298. Proc. Natl. Acad. Sci. USA 97, 2832–2835 (2000).
  Article CAS Google Scholar
• Perreault, M., Dombrowski, L. & Marette, A. Mechanism of impaired nitric oxide synthase activity in skeletal muscle of streptozotocin-induced diabetic rats. Diabetologia 43, 427–437 (2000).
  Article CAS Google Scholar