The translation factor eIF-4E promotes tumor formation and cooperates with c-Myc in lymphomagenesis (original) (raw)

Nature Medicine volume 10, pages 484–486 (2004)Cite this article

Abstract

The mammalian target of rapamycin, mTOR, regulates cell growth and proliferation. Here we show that the initiation factor of translation (eIF-4E), a downstream effector of mTOR, has oncogenic effects in vivo and cooperates with c-Myc in B-cell lymphomagenesis. We found that c-Myc overrides eIF-4E-induced cellular senescence, whereas eIF-4E antagonizes c-Myc-dependent apoptosis in vivo. Our results implicate activation of eIF-4E as a key event in oncogenic transformation by phosphoinositide-3 kinase and Akt.

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Acknowledgements

This work was partially supported by the National Cancer Institute and the Irma T. Hirschl/Monique Weill-Caulier Award to P.P.P. We thank L. DiSantis for editing the manuscript and M. Barna, L. Longo and C. Tonini for support and suggestions.

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Author notes

  1. Davide Ruggero
    Present address: Fox Chase Cancer Center, Human Genetics Program, 333 Cottman Avenue, Philadelphia, Pennsylvania, 19111, USA

Authors and Affiliations

  1. Cancer Biology and Genetics Program, Sloan-Kettering Institute, Memorial Sloan-Kettering Cancer Center, New York, 10021, New York, USA
    Davide Ruggero, Lorenzo Montanaro, Li Ma, Wei Xu & Pier Paolo Pandolfi
  2. Department of Pathology, Sloan-Kettering Institute, Memorial Sloan-Kettering Cancer Center, New York, 10021, New York, USA
    Davide Ruggero, Lorenzo Montanaro, Li Ma, Wei Xu, Carlos Cordon-Cardo & Pier Paolo Pandolfi
  3. Università di Bari–Dipartimento di Biochimica Medica e Biologica Medica, Piazzale Giulio Cesare, Bari, 70124, Italy
    Paola Londei

Authors

  1. Davide Ruggero
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  2. Lorenzo Montanaro
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  3. Li Ma
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  4. Wei Xu
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  5. Paola Londei
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  6. Carlos Cordon-Cardo
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  7. Pier Paolo Pandolfi
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Correspondence toPier Paolo Pandolfi.

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Ruggero, D., Montanaro, L., Ma, L. et al. The translation factor eIF-4E promotes tumor formation and cooperates with c-Myc in lymphomagenesis.Nat Med 10, 484–486 (2004). https://doi.org/10.1038/nm1042

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