The translation factor eIF-4E promotes tumor formation and cooperates with c-Myc in lymphomagenesis (original) (raw)
- Brief Communication
- Published: 18 April 2004
- Lorenzo Montanaro1,2,
- Li Ma1,2,
- Wei Xu1,2,
- Paola Londei3,
- Carlos Cordon-Cardo2 &
- …
- Pier Paolo Pandolfi1,2
Nature Medicine volume 10, pages 484–486 (2004)Cite this article
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Abstract
The mammalian target of rapamycin, mTOR, regulates cell growth and proliferation. Here we show that the initiation factor of translation (eIF-4E), a downstream effector of mTOR, has oncogenic effects in vivo and cooperates with c-Myc in B-cell lymphomagenesis. We found that c-Myc overrides eIF-4E-induced cellular senescence, whereas eIF-4E antagonizes c-Myc-dependent apoptosis in vivo. Our results implicate activation of eIF-4E as a key event in oncogenic transformation by phosphoinositide-3 kinase and Akt.
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Acknowledgements
This work was partially supported by the National Cancer Institute and the Irma T. Hirschl/Monique Weill-Caulier Award to P.P.P. We thank L. DiSantis for editing the manuscript and M. Barna, L. Longo and C. Tonini for support and suggestions.
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- Davide Ruggero
Present address: Fox Chase Cancer Center, Human Genetics Program, 333 Cottman Avenue, Philadelphia, Pennsylvania, 19111, USA
Authors and Affiliations
- Cancer Biology and Genetics Program, Sloan-Kettering Institute, Memorial Sloan-Kettering Cancer Center, New York, 10021, New York, USA
Davide Ruggero, Lorenzo Montanaro, Li Ma, Wei Xu & Pier Paolo Pandolfi - Department of Pathology, Sloan-Kettering Institute, Memorial Sloan-Kettering Cancer Center, New York, 10021, New York, USA
Davide Ruggero, Lorenzo Montanaro, Li Ma, Wei Xu, Carlos Cordon-Cardo & Pier Paolo Pandolfi - Università di Bari–Dipartimento di Biochimica Medica e Biologica Medica, Piazzale Giulio Cesare, Bari, 70124, Italy
Paola Londei
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Correspondence toPier Paolo Pandolfi.
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Ruggero, D., Montanaro, L., Ma, L. et al. The translation factor eIF-4E promotes tumor formation and cooperates with c-Myc in lymphomagenesis.Nat Med 10, 484–486 (2004). https://doi.org/10.1038/nm1042
- Received: 17 February 2004
- Accepted: 05 April 2004
- Published: 18 April 2004
- Issue Date: 01 May 2004
- DOI: https://doi.org/10.1038/nm1042