The transcription factor SNAIL represses vitamin D receptor expression and responsiveness in human colon cancer (original) (raw)
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- Published: 22 August 2004
- María Jesús Larriba1 na1,
- José Miguel García2,
- Paloma Ordóñez-Morán1,
- Cristina Peña2,
- Sandra Peiró3,
- Isabel Puig3,
- Rufo Rodríguez4,
- Ricardo de la Fuente5,
- Antonio Bernad5,
- Marina Pollán6,
- Félix Bonilla2,
- Carlos Gamallo7,
- Antonio García de Herreros3 &
- …
- Alberto Muñoz1
Nature Medicine volume 10, pages 917–919 (2004)Cite this article
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Abstract
Several non-hypercalcemic analogs of 1α,25-dihydroxyvitamin D3 (1,25(OH)2D3) show antitumor activity in a subset of cancer patients. High vitamin D receptor (VDR) expression, which is associated with good prognosis but is lost during tumor progression. We show that the SNAIL transcription factor represses VDR gene expression in human colon cancer cells and blocks the antitumor action of EB1089, a 1,25(OH)2D3 analog, in xenografted mice. In human colon cancers, elevated SNAIL expression correlates with downregulation of VDR.
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Acknowledgements
We thank L. Binderup for 1,25(OH)2D3 and EB1089, T. González for calcemia measurement and R. Rycroft for his help with the English manuscript. This study was supported by grants from Fundación Científica de la Asociación Española contra el Cáncer, Ministerio de Ciencia y Tecnología (SAF01-2291) and Instituto de Salud Carlos III (FIS03-C03/10) of Spain.
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- Héctor G Pálmer and María Jesús Larriba: These authors contributed equally to this work.
Authors and Affiliations
- Instituto de Investigaciones Biomédicas “Alberto Sols,” Consejo Superior de Investigaciones Científicas–Universidad Autónoma de Madrid, Madrid, E-28029, Spain
Héctor G Pálmer, María Jesús Larriba, Paloma Ordóñez-Morán & Alberto Muñoz - Hospital Universitario Puerta de Hierro, Madrid, E-28035, Spain
José Miguel García, Cristina Peña & Félix Bonilla - Institut Municipal d'Investigació Mèdica–Universitat Pompeu-Fabra, Barcelona, E-08003, Spain
Sandra Peiró, Isabel Puig & Antonio García de Herreros - Hospital Virgen de la Salud, Toledo, E-45004, Spain
Rufo Rodríguez - Centro Nacional de Biotecnología, Madrid, E-28049, Spain
Ricardo de la Fuente & Antonio Bernad - Centro Nacional de Epidemiología, Madrid, E-28029, Spain
Marina Pollán - Hospital Universitario de la Princesa, Madrid, E-28006, Spain
Carlos Gamallo
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- Héctor G Pálmer
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Correspondence toAlberto Muñoz.
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Pálmer, H., Larriba, M., García, J. et al. The transcription factor SNAIL represses vitamin D receptor expression and responsiveness in human colon cancer.Nat Med 10, 917–919 (2004). https://doi.org/10.1038/nm1095
- Received: 11 June 2004
- Accepted: 29 July 2004
- Published: 22 August 2004
- Issue Date: 01 September 2004
- DOI: https://doi.org/10.1038/nm1095