The transcription factor SNAIL represses vitamin D receptor expression and responsiveness in human colon cancer (original) (raw)

Nature Medicine volume 10, pages 917–919 (2004)Cite this article

Abstract

Several non-hypercalcemic analogs of 1α,25-dihydroxyvitamin D3 (1,25(OH)2D3) show antitumor activity in a subset of cancer patients. High vitamin D receptor (VDR) expression, which is associated with good prognosis but is lost during tumor progression. We show that the SNAIL transcription factor represses VDR gene expression in human colon cancer cells and blocks the antitumor action of EB1089, a 1,25(OH)2D3 analog, in xenografted mice. In human colon cancers, elevated SNAIL expression correlates with downregulation of VDR.

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Acknowledgements

We thank L. Binderup for 1,25(OH)2D3 and EB1089, T. González for calcemia measurement and R. Rycroft for his help with the English manuscript. This study was supported by grants from Fundación Científica de la Asociación Española contra el Cáncer, Ministerio de Ciencia y Tecnología (SAF01-2291) and Instituto de Salud Carlos III (FIS03-C03/10) of Spain.

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Author notes

  1. Héctor G Pálmer and María Jesús Larriba: These authors contributed equally to this work.

Authors and Affiliations

  1. Instituto de Investigaciones Biomédicas “Alberto Sols,” Consejo Superior de Investigaciones Científicas–Universidad Autónoma de Madrid, Madrid, E-28029, Spain
    Héctor G Pálmer, María Jesús Larriba, Paloma Ordóñez-Morán & Alberto Muñoz
  2. Hospital Universitario Puerta de Hierro, Madrid, E-28035, Spain
    José Miguel García, Cristina Peña & Félix Bonilla
  3. Institut Municipal d'Investigació Mèdica–Universitat Pompeu-Fabra, Barcelona, E-08003, Spain
    Sandra Peiró, Isabel Puig & Antonio García de Herreros
  4. Hospital Virgen de la Salud, Toledo, E-45004, Spain
    Rufo Rodríguez
  5. Centro Nacional de Biotecnología, Madrid, E-28049, Spain
    Ricardo de la Fuente & Antonio Bernad
  6. Centro Nacional de Epidemiología, Madrid, E-28029, Spain
    Marina Pollán
  7. Hospital Universitario de la Princesa, Madrid, E-28006, Spain
    Carlos Gamallo

Authors

  1. Héctor G Pálmer
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  2. María Jesús Larriba
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  3. José Miguel García
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  4. Paloma Ordóñez-Morán
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  5. Cristina Peña
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  6. Sandra Peiró
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  7. Isabel Puig
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  8. Rufo Rodríguez
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  9. Ricardo de la Fuente
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  10. Antonio Bernad
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  11. Marina Pollán
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  12. Félix Bonilla
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  13. Carlos Gamallo
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  14. Antonio García de Herreros
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  15. Alberto Muñoz
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Corresponding author

Correspondence toAlberto Muñoz.

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The authors declare no competing financial interests.

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Pálmer, H., Larriba, M., García, J. et al. The transcription factor SNAIL represses vitamin D receptor expression and responsiveness in human colon cancer.Nat Med 10, 917–919 (2004). https://doi.org/10.1038/nm1095

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