A secreted FGF-binding protein can serve as the angiogenic switch in human cancer (original) (raw)

References

1. Weidner, N. Intratumor microvessel density as a prognostic factor in cancer. Am. J. Pathol. 147, 9–19 (1995).
   CAS PubMed PubMed Central Google Scholar
2. Liotta, L.A., Steeg, P.S., & Stetler-Stevenson, W.G. Cancer metastasis and angiogenesis: An imbalance of positive and negative regulation. Cell 64, 327–336 (1991).
   Article CAS PubMed Google Scholar
3. Hanahan, D. & Folkman, J. Patterns and emerging mechanisms of the angiogenic switch during tumorigenesis. Cell 86, 353–364 (1996).
   Article CAS PubMed Google Scholar
4. Dvorak, H.F., Brown, L.F., Detmar, M. & Dvorak, A.M. Vascular permeability factor/vascular endothelial growth factor, microvascular hyperpermeability, and angiogenesis. Am. J. Pathol. 146, 1029–1039 (1995).
   CAS PubMed PubMed Central Google Scholar
5. Schulte, A.M. et al. Human trophoblast and choriocarcinoma expression of the growth factor pleiotrophin attributable to germ line insertion of an endogenous retrovirus. Proc. Natl. Acad. Sci. USA 93, 14759–14764 (1996).
   Article CAS PubMed PubMed Central Google Scholar
6. Czubayko, F., Schulte, A.M., Berchem, G.J. & Wellstein, A. Melanoma angiogenesis and metastasis modulated by ribozyme targeting of the secreted growth factor pleiotrophin. Proc. Natl. Acad. Sci. USA 93, 14753–14758 (1996).
   Article CAS PubMed PubMed Central Google Scholar
7. Asano, M., Yukita, A., Matsumoto, T., Kondo, S. & Suzuki, H. Inhibition of tumor growth and metastasis by an immunoneutralizing monoclonal antibody to human vascular endothelial growth factor/vascular permeability factor 121. Cancer Res. 55, 5296–5301 (1995).
   CAS PubMed Google Scholar
8. Warren, R.S., Yuan, H., Matli, M.R., Gillett, N.A. & Ferrara, N. Regulation by vascular endothelial growth factor of human colon cancer tumorigenesis in a mouse model of experimental liver metastasis. J. Clin. Invest. 95, 1789–1797 (1995).
   Article CAS PubMed PubMed Central Google Scholar
9. Wu, D., Kan, M., Sato, G.H., Okamoto, T. & Sato, J.D. Characterization and molecular cloning of a putative binding protein for heparin-binding growth factors. J. Biol. Chem. 266, 16778–16785 (1991).
   CAS PubMed Google Scholar
10. Czubayko, F., Smith, R.V., Chung, H.C. & Wellstein, A. Tumor growth and angiogenesis induced by a secreted binding protein for fibroblast growth factors. J. Biol. Chem, 269, 28243–28248 (1994).
    CAS PubMed Google Scholar
11. Burgess, W.H. & Maciag, T. The heparin-binding (fibroblast) growth factor family of proteins. Annu. Rev. Biochem. 58, 575–606 (1989).
    Article CAS PubMed Google Scholar
12. Liaudet-Coopman, E.D.E. & Wellstein, A. Regulation of gene expression of a binding protein for fibroblast growth factor by retinoic acid. J. Biol. Chem. 271, 21303–21308 (1996).
    Article CAS PubMed Google Scholar
13. Kurtz, A., Darwiche, N., Harris, V., Wang, H.L. & Wellstein, A. Expression of a binding protein for FGF is associated with epithelial development and skin carcinogenesis. Oncogene 14, 2671–2681 (1997).
    Article CAS PubMed Google Scholar
14. Czubayko, F., Riegel, A.T. & Wellstein, A. Ribozyme-targeting elucidates a direct role of pleiotrophin in tumor growth. J. Biol. Chem. 269, 21358–21363 (1994).
    CAS PubMed Google Scholar
15. Li, Y.S. et al. Cloning and expression of a developmentally regulated protein that induces mitogenic and neurite outgrowth activity. Science 250, 1690–1694 (1990).
    Article CAS PubMed Google Scholar
16. Fang, W.J., Hartmann, N., Chow, D., Riegel, A.T. & Wellstein, A. Pleiotrophin stimulates fibroblasts, endothelial and epithelial cells, and is expressed in human cancer. J. Biol. Chem. 267, 25889–25897 (1992).
    CAS PubMed Google Scholar
17. Liaudet-Coopman, E.D.E., Berchem, G.J. & Wellstein, A. In vivo inhibition of angiogenesis and induction of apoptosis by retinoic acid in squamous cell carcinoma. Clin. Cancer Res. 3, 179–184 (1997).
    CAS PubMed Google Scholar
18. Horak, E.R. et al. Angiogenesis, assessed by platelet/endothelial Cell adhesion molecule antibodies, as indicator of node metastases and survival in breast cancer. Lancet 340, 1120–1124 (1992).
    Article CAS PubMed Google Scholar
19. Kuan, S.F., Byrd, J.C., Basbaum, C.B. & Kim, Y.S. Characterization of quantitative mucin variants from a human colon cancer cell line. Cancer Res. 47, 5715–5724 (1987).
    CAS PubMed Google Scholar
20. Chen, C.J., Banerjea, A.C., Harmison, G.G., Haglund, K. & Schubert, M. Multi-target-ribozyme directed to cleave at up to nine highly conserved HIV-1 env RNA regions inhibits HIV-1 replication—potential effectiveness against most presently sequenced HIV-1 isolates. Nucleic Acids Res. 20, 4581–4589 (1992).
    Article CAS PubMed PubMed Central Google Scholar

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