Cathepsin L is required for endothelial progenitor cell–induced neovascularization (original) (raw)

• Isner, J.M. & Asahara, T. Angiogenesis and vasculogenesis as therapeutic strategies for postnatal neovascularization. J. Clin. Invest. 103, 1231–1236 (1999).
  Article CAS Google Scholar
• Folkman, J. Angiogenesis in cancer, vascular, rheumatoid and other disease. Nat. Med. 1, 27–31 (1995).
  Article CAS Google Scholar
• Risau, W. Mechanisms of angiogenesis. Nature 386, 671–674 (1997).
  Article CAS Google Scholar
• Carmeliet, P. & Jain, R.K. Angiogenesis in cancer and other diseases. Nature 407, 249–257 (2000).
  Article CAS Google Scholar
• Asahara, T. et al. Isolation of putative progenitor endothelial cells for angiogenesis. Science 275, 964–967 (1997).
  Article CAS Google Scholar
• Shi, Q. et al. Evidence for circulating bone marrow-derived endothelial cells. Blood 92, 362–367 (1998).
  CAS PubMed Google Scholar
• Kalka, C. et al. Transplantation of ex vivo expanded endothelial progenitor cells for therapeutic neovascularization. Proc. Natl. Acad. Sci. USA 97, 3422–3427 (2000).
  Article CAS Google Scholar
• Kawamoto, A. et al. Therapeutic potential of ex vivo expanded endothelial progenitor cells for myocardial ischemia. Circulation 103, 634–647 (2001).
  Article CAS Google Scholar
• Assmus, B. et al. Transplantation of Progenitor Cells and Regeneration Enhancement in Acute Myocardial Infarction (TOPCARE-AMI). Circulation 106, 3009–3017 (2002).
  Article Google Scholar
• Kocher, A.A. et al. Neovascularization of ischemic myocardium by human bone-marrow-derived angioblasts prevents cardiomyocyte apoptosis, reduces remodeling and improves cardiac function. Nat. Med. 7, 430–436 (2001).
  Article CAS Google Scholar
• Joyce, J.A. et al. Cathepsin cysteine proteases are effectors of invasive growth and angiogenesis during multistage tumorigenesis. Cancer Cell 5, 443–453 (2004).
  Article CAS Google Scholar
• Berchem, G. et al. Cathepsin-D affects multiple tumor progression steps in vivo: proliferation, angiogenesis and apoptosis. Oncogene 21, 5951–5955 (2002).
  Article CAS Google Scholar
• Krueger, S., Kellner, U., Buehling, F. & Roessner, A. Cathepsin L antisense oligonucleotides in a human osteosarcoma cell line: effects on the invasive phenotype. Cancer Gene Ther. 8, 522–528 (2001).
  Article CAS Google Scholar
• Dimmeler, S. et al. HMG-CoA reductase inhibitors (statins) increase endothelial progenitor cells via the PI 3-kinase/Akt pathway. J. Clin. Invest. 108, 391–397. (2001).
  Article CAS Google Scholar
• Vasa, M. et al. Number and migratory activity of circulating endothelial progenitor cells inversely correlate with risk factors for coronary artery disease. Circ. Res. 89, E1–7 (2001).
  Article Google Scholar
• Urbich, C. et al. Relevance of monocytic features for neovascularization capacity of circulating endothelial progenitor cells. Circulation 108, 2511–2516 (2003).
  Article Google Scholar
• Fiebiger, E. et al. Invariant chain controls the activity of extracellular cathepsin L. J. Exp. Med. 196, 1263–1269 (2002).
  Article CAS Google Scholar
• Walker, B., Lynas, J.F., Meighan, M.A. & Bromme, D. Evaluation of dipeptide alpha-keto-beta-aldehydes as new inhibitors of cathepsin S. Biochem. Biophys. Res. Commun. 275, 401–405 (2000).
  Article CAS Google Scholar
• Li, Z. et al. Regulation of collagenase activities of human cathepsins by glycosaminoglycans. J. Biol. Chem. 279, 5470–5479 (2004).
  Article CAS Google Scholar
• Chauhan, S.S., Ray, D., Kane, S.E., Willingham, M.C. & Gottesman, M.M. Involvement of carboxy-terminal amino acids in secretion of human lysosomal protease cathepsin L. Biochemistry 37, 8584–8594 (1998).
  Article CAS Google Scholar
• Libby, P. & Schonbeck, U. Drilling for oxygen: angiogenesis involves proteolysis of the extracellular matrix. Circ. Res. 89, 195–197 (2001).
  Article CAS Google Scholar
• Carmeliet, P. Mechanisms of angiogenesis and arteriogenesis. Nat. Med. 6, 389–395 (2000).
  Article CAS Google Scholar
• Devy, L. et al. The pro- or antiangiogenic effect of plasminogen activator inhibitor 1 is dose dependent. FASEB J. 16, 147–154 (2002).
  Article CAS Google Scholar
• Rooprai, H.K. & McCormick, D. Proteases and their inhibitors in human brain tumours: a review. Anticancer Res. 17, 4151–4162 (1997).
  CAS PubMed Google Scholar
• Turk, V., Turk, B. & Turk, D. Lysosomal cysteine proteases: facts and opportunities. EMBO J. 20, 4629–4633 (2001).
  Article CAS Google Scholar
• Stypmann, J. et al. Dilated cardiomyopathy in mice deficient for the lysosomal cysteine peptidase cathepsin L. Proc. Natl. Acad. Sci. USA 99, 6234–6239 (2002).
  Article CAS Google Scholar
• Tobin, D.J. et al. The lysosomal protease cathepsin L is an important regulator of keratinocyte and melanocyte differentiation during hair follicle morphogenesis and cycling. Am. J. Pathol. 160, 1807–1821 (2002).
  Article CAS Google Scholar
• Shi, G.P. et al. Deficiency of the cysteine protease cathepsin S impairs microvessel growth. Circ. Res. 92, 493–500 (2003).
  Article CAS Google Scholar
• Lyden, D. et al. Impaired recruitment of bone-marrow-derived endothelial and hematopoietic precursor cells blocks tumor angiogenesis and growth. Nat. Med. 7, 1194–1201 (2001).
  Article CAS Google Scholar
• Rafii, S., Lyden, D., Benezra, R., Hattori, K. & Heissig, B. Vascular and haematopoietic stem cells: novel targets for anti-angiogenesis therapy? Nat. Rev. Cancer 2, 826–835 (2002).
  Article CAS Google Scholar
• Nakagawa, T. et al. Cathepsin L: critical role in Ii degradation and CD4 T cell selection in the thymus. Science 280, 450–453 (1998).
  Article CAS Google Scholar
• Roth, W. et al. Cathepsin L deficiency as molecular defect of furless: hyperproliferation of keratinocytes and pertubation of hair follicle cycling. FASEB J. 14, 2075–2086 (2000).
  Article CAS Google Scholar
• Houseweart, M.K. et al. Cathepsin B but not cathepsins L or S contributes to the pathogenesis of Unverricht-Lundborg progressive myoclonus epilepsy (EPM1). J. Neurobiol. 56, 315–327 (2003).
  Article CAS Google Scholar
• Saftig, P. et al. Mice deficient for the lysosomal proteinase cathepsin D exhibit progressive atrophy of the intestinal mucosa and profound destruction of lymphoid cells. EMBO J. 14, 3599–3608 (1995).
  Article CAS Google Scholar
• Lelongt, B. et al. Matrix metalloproteinase 9 protects mice from anti-glomerular basement membrane nephritis through its fibrinolytic activity. J. Exp. Med. 193, 793–802 (2001).
  Article CAS Google Scholar
• Urbich, C. et al. Dephosphorylation of endothelial nitric oxide synthase contributes to the anti-angiogenic effects of endostatin. FASEB J. 16, 706–708 (2002).
  Article CAS Google Scholar
• Premzl, A., Zavasnik-Bergant, V., Turk, V. & Kos, J. Intracellular and extracellular cathepsin B facilitate invasion of MCF-10A neoT cells through reconstituted extracellular matrix in vitro. Exp. Cell. Res. 283, 206–214 (2003).
  Article CAS Google Scholar
• Aicher, A. et al. Essential role of endothelial nitric oxide synthase for mobilization of stem and progenitor cells. Nat. Med. 9, 1370–1376 (2003).
  Article CAS Google Scholar
• Dennhofer, R. et al. Invasion of melanoma cells into dermal connective tissue in vitro: evidence for an important role of cysteine proteases. Int. J. Cancer 106, 316–323 (2003).
  Article Google Scholar
• Kaberdin, V.R. & McDowall, K.J. Expanding the use of zymography by the chemical linkage of small, defined substrates to the gel matrix. Genome Res. 13, 1961–1965 (2003).
  CAS PubMed PubMed Central Google Scholar
• Hinds, K.A. et al. Highly efficient endosomal labeling of progenitor and stem cells with large magnetic particles allows magnetic resonance imaging of single cells. Blood 102, 867–872 (2003).
  Article CAS Google Scholar