Does antisense exist? (original) (raw)

Nature Medicine volume 1, pages 1119–1121 (1995)Cite this article

It may, but only under very special circumstances.

This is a preview of subscription content, access via your institution

Relevant articles

Open Access articles citing this article.

Access options

Subscribe to this journal

Receive 12 print issues and online access

$209.00 per year

only $17.42 per issue

Buy this article

Prices may be subject to local taxes which are calculated during checkout

Additional access options:

References

  1. Gao, W., Han, F., Storm, C., Egan, W. & Cheng, Y.C. Phosphorothioate oligonucleotides are inhbitiors of human DNA polymerases and RNAse H: Implications for antisense technology. Mol. Pharmac. 41, 223–229 (1992).
    CAS Google Scholar
  2. Yakubov, L. et al. Oligodeoxynucleotides interact with recombinant CD4 at multiple sites. J. Biol. Chem. 268, 18818–18823 (1993).
    CAS PubMed Google Scholar
  3. Stein, C.A., Cleary, A.M., Yakubov, L. & Lederman, S. Phosphorothioate oligodeoxynucleotides bind to the third variable loop domain (v3) of human immunodeficiency virus Type 1 gp120. Antisense Res. Devel. 3, 19–31 (1993).
    Article CAS Google Scholar
  4. Guvakova, M.A., Yakubov, L.A., Vlodavsky, I., Tonkinson, J.L. & Stein, C.A. Phosphorothioate oligodeoxynucleotides bind to basic fibroblast growth factor, inhibit its binding to cell surface receptors, and remove it from low affinity binding sites on extracellular matrix. J. biol. Chem. 270, 2620–2627 (1995).
    Article CAS Google Scholar
  5. Simons, M., Edelman, E., DeKeyser, J., Langer, R. & Rosenberg, R. Antisense c-myb oligonucleotides inhibit intimal arterial smooth muscle cell accumulation in vivo. Nature 359, 67–70 (1992).
    Article CAS Google Scholar
  6. Burgess, T. et al. The antiproliferative activity of c-myb and c-myc antisense oligonucleotides in smooth muscle cells is casued by a nonantisense mechanism. Proc. natn. Acad. Sci. U.S.A. 92, 4051–4055 (1995).
    Article CAS Google Scholar
  7. Lallier, T. and Bronner-Fraser, M. Inhibition of neural crest cell attachment by integrin antisense oligonucleotides. Science 259, 692–695 (1993).
    Article CAS Google Scholar
  8. Maltese, J., Sharma, H., Vassilev, L. & Narayanan, R. Sequence context of antisense RelA/NF-κB phosphorothioates determines specificity. Nucleic Acids Res. 23, 1146–1151 (1995).
    Article CAS Google Scholar
  9. Krieg, A. et al. CpG motifs in bacterial DNA trigger direct B-cell activation. Nature 374, 546–549 (1995)
    Article CAS Google Scholar
  10. Tamamoto, T., Yamamoto, S., Kataoka, T. & Tokunaga, T. Ability of oligonucleotides with certain palindromes to induce interferon production and augment natural killer cell activity is associated with their base length. Antisense Res. Devel. 4, 119–122 (1994).
    Article Google Scholar
  11. Yamamoto, S. et al. DNA from bacateria, but not from vertebrates, induces interferons, activates natural killer cells and inhibits tumor growth. Microbiol. Immun. 36, 983–987 (1992).
    Article CAS Google Scholar
  12. Stein, C.A. & Krieg, A. Problems in interpretation of data derived from in vitro and in vivo use of antisense oligodeoxynucleotides. Antisense Res. Devel. 4, 67–69 (1994).
    Article CAS Google Scholar

Download references

Author information

Authors and Affiliations

  1. Columbia University College of Physicians and Surgeons, New York, New York, 10032, USA
    C.A. Stein

Authors

  1. C.A. Stein
    You can also search for this author inPubMed Google Scholar

Rights and permissions

About this article

Cite this article

Stein, C. Does antisense exist?.Nat Med 1, 1119–1121 (1995). https://doi.org/10.1038/nm1195-1119

Download citation

This article is cited by