Frequency of recurrent BRCA1 and BRCA2 mutations in Ashkenazi Jewish breast cancer families (original) (raw)

Two founding mutations in BRCA1 and BRCA2 are responsible for a large proportion of Jewish families with the breast-ovarian cancer syndrome.

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Authors and Affiliations

1. Department of Medicine, Division of Medical Genetics, and Department of Human Genetics, McGill University and Montreal General Hospital Research Institute, 1650 Cedar Avenue, Montreal, Canada, H3G 1A4
   P. Tonin
2. Departments of Medicine and Genetics, University of Pennsylvania, 3400 Spruce Street, Philadelphia, Pennsylvania, 19104, USA
   B. Weber & F. Couch
3. Clinical Genetics Service, Department of Human Genetics, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue New York, New York, 10021, USA
   K. Offit
4. Departments of Biostatistics and Epidemiology, University of Pennsylvania, 423 Guardian Drive, Philadelphia, Pennsylvania, 19104, USA
   T.R. Rebbeck
5. Genetic Epidemiology Group, Department of Medical Informatics, University of Utah, 391 Chipeta Way, Salt Lake City, Utah, 84108, USA
   S. Neuhausen
6. Divisions of Basic Science, 7701 Bumholme Avenue, Philadelphia, Pennsylvania, 19111, USA
   A.K. Godwin & D. Berman
7. Population Science, Fox Chase Cancer Center, 7701 Bumholme Avenue, Philadelphia, Pennsylvania, 19111, USA
   M. Daly & J. Wagner-Costalos
8. Department of Medicine, Division of Hematology/Oncology, Cooper Hospital, 1 Cooper Plaza, Camden, New Jersey, 08103, USA
   G. Grana
9. Division of Human Cancer Genetics, Dana-Farber Cancer Institute, 44 Binney Street, Boston, Massachusetts, 02115, USA
   E. Fox, M.F. Kane & R.D. Kolodner
10. Center for Cancer Risk Analysis, Massachusetts General Hospital, Cancer Center Charlestown, Massachusetts, 02129, USA
    M. Krainer & D.A. Haber
11. Genetic Epidemiology Branch, National Cancer Institute and Laboratory of Gene Transfer, National Center for Human Genome Research, National Institutes of Health, 6310 Executive Boulevard, Bethesda, Maryland, 20892, USA
    J.P. Struewing
12. Division of Medical Oncology, Toronto-Sunnybrook Regional Cancer Center, 2075 Bayview Avenue, Toronto, Canada, M4N 3M5
    E. Warner
13. Department of Obstetrics and Gynecology, The Toronto Hospital, 200 Elizabeth Street, Toronto, Canada, MSG 2C4
    B. Rosen
14. Lombardi Cancer Center, Georgetown University Medical Center, 2233 Wisconsin Avenue, Washington, DC, 20007, USA
    C. Lerman & B. Peshkin
15. Breast Cancer Medicine Service, Department of Medicine, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York, New York, 10021, USA
    L. Norton
16. International Agency for Research on Cancer, 150 Cours, Albert Thomas, 69372, Lyon, France
    O. Serova & G.M. Lenoir
17. Cancer Prevention Research Unit, Sir M.B. Davis Jewish General Hospital, Montreal, Quebec, Canada, H3T1E2
    W.D. Foulkes
18. Department of Preventive Medicine and Public Health, Creighton University School of Medicine, Omaha, Nebraska, 68178, USA
    H.T. Lynch
19. Department of Medicine, Women's College Hospital, University of Toronto, 790 Bay Street, Room 750, Toronto, Ontario, Canada, M5G 1N8
    S.A. Narod
20. Division of Cancer Epidemiology and Control, Dana-Farber Cancer Institute, 44 Binney Street, Boston, Massachusetts, 02115, USA
    J.E. Garber

Authors

1. P. Tonin
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2. B. Weber
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3. K. Offit
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4. F. Couch
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5. T.R. Rebbeck
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6. S. Neuhausen
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7. A.K. Godwin
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8. M. Daly
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9. J. Wagner-Costalos
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10. D. Berman
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11. G. Grana
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12. E. Fox
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13. M.F. Kane
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14. R.D. Kolodner
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15. M. Krainer
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16. D.A. Haber
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17. J.P. Struewing
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18. E. Warner
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19. B. Rosen
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20. C. Lerman
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21. B. Peshkin
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22. L. Norton
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23. O. Serova
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24. W.D. Foulkes
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25. H.T. Lynch
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26. G.M. Lenoir
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27. S.A. Narod
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28. J.E. Garber
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Tonin, P., Weber, B., Offit, K. et al. Frequency of recurrent BRCA1 and BRCA2 mutations in Ashkenazi Jewish breast cancer families.Nat Med 2, 1179–1183 (1996). https://doi.org/10.1038/nm1196-1179

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• Received: 17 January 1994
• Accepted: 06 December 1994
• Issue Date: 01 November 1996
• DOI: https://doi.org/10.1038/nm1196-1179