The role of a mutant CCR5 allele in HIV–1 transmission and disease progression (original) (raw)

Nature Medicine volume 2, pages 1240–1243 (1996)Cite this article

Abstract

A 32–nucleotide deletion (δ32) within the β–chemokine receptor 5 (CCR5) gene has been described in subjects who remain uninfected despite extensive exposure to HIV–1. This allele was found to be common in the Caucasian population with a frequency of 0.0808, but was not found in people of African or Asian ancestry. To determine its role in HIV–1 transmission and disease progression, we analyzed the CCR5 genotype of 1252 homosexual men enrolled in the Chicago component of the Multicenter AIDS Cohort Study (MACS). No infected participant was found to be homozygous for the 32 allele, whereas 3.6% of at–risk but uninfected Caucasian participants were homozygous, showing the highly protective role of this genotype against sexual acquisition of HIV–1. No evidence was found to suggest that heterozygotes were protected against HIV–1 infection, but a limited protective role against disease progression was noted. The 32 allele of CCR5 is therefore an important host factor in HIV–1 transmission and pathogenesis.

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HIV infection

Article 17 August 2023

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Author notes

  1. Avidan U. Neumann
    Present address: Human Biology Research Center, Hadassah Hospital, Jerusalem, 91120, Israel
  2. Yaoxing Huang and William A. Paxton: These two authors contributed equally to this work.

Authors and Affiliations

  1. The Aaron Diamond AIDS Research Center and The Rockefeller University, 455 First Avenue, New York, New York, 10016, USA
    Yaoxing Huang, William A. Paxton, Linqi Zhang, Tian He, Stanley Kang, Daniel Ceradini, Zhanqun Jin, Nathaniel R. Landau, David D. Ho & Richard A. Koup
  2. Department of Medicine, Northwestern University Medical School, 303 East Chicago Avenue, Chicago, Illinois, 60611, USA
    Steven M. Wolinsky, Kevin Kunstman, Daniel Erickson & John Phair
  3. Theoretical Division, T-10, Los Alamos National Laboratories, Los Alamos, New Mexico, 87545, USA
    Avidan U. Neumann
  4. Laboratory of Immunochemistry, The Lindsley F. Kimball Research Institute of the New York Blood Center, New York, New York, 10021, USA
    Karina Yazdanbakhsh
  5. Roche Molecular Systems, Branchburg, New Jersey, 08876, USA
    Elizabeth Dragon

Authors

  1. Yaoxing Huang
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  2. William A. Paxton
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  3. Steven M. Wolinsky
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  4. Avidan U. Neumann
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  5. Linqi Zhang
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  6. Tian He
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  7. Stanley Kang
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  8. Daniel Ceradini
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  9. Zhanqun Jin
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  10. Karina Yazdanbakhsh
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  11. Kevin Kunstman
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  12. Daniel Erickson
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  13. Elizabeth Dragon
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  14. Nathaniel R. Landau
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  15. John Phair
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  16. David D. Ho
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  17. Richard A. Koup
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Huang, Y., Paxton, W., Wolinsky, S. et al. The role of a mutant CCR5 allele in HIV–1 transmission and disease progression.Nat Med 2, 1240–1243 (1996). https://doi.org/10.1038/nm1196-1240

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