Glucose intolerance but normal satiety in mice with a null mutation in the glucagon–like peptide 1 receptor gene (original) (raw)
References
Creutzfeldt, W. & Ebert, R. New developments in the incretin concept today. Diabetologi28, 565–573 (1985). ArticleCAS Google Scholar
Mojsov, S., Weir, G.C. & Habener, J.F., Glucagon-like peptide I (7–37) co-encoded in the glucagon gene is potent stimulator of insulin release in the perfused rat pancreas. J. Clin. Invest.79, 616–619 (1987). ArticleCAS Google Scholar
Kreymann, B., Ghatei, M.A., Williams, G. & Bloom, S.R. Glucagon-like peptide-1 7–36:A physiological incretin in man. Lancetii, 1300–304 (1987). Article Google Scholar
Holst, J.J., Orskov, C., Nielsen, O.V. & Schwartz, T.W. Truncated glucagon-like peptide I, an insulin-releasing hormone from the distal gut. FERS Lett.211, 169–174 (1987). CAS Google Scholar
Fehmann, H.-C., Goke, R. & Goke, B. Cell and molecular biology of the incretin hormones glucagon-like peptide 1 and glucose-dependent releasing polypeptide. Endocrine Rev.16, 390–410 (1995). ArticleCAS Google Scholar
Turton, M.D. et al. role for glucagon-like peptide-1 in the central regulation of feeding. Nature379, 69–72 (1996). ArticleCAS Google Scholar
Nauck, M.A. et al. Preserved incretin activity of glucagon-like peptide 1 [7–36 amide] but not of synthetic human gastric inhibitory polypeptide in patients with type-2 diabetes mellitus. J. Clin. Invest.91, 301–307 (1993). ArticleCAS Google Scholar
Nauck, M.A. et al> Normalization of fasting hyperglycaemi by exogenous glucagon-like peptide 1 (7–36 amide) in type 2 (non-insulin-dependent) dibetic patients. Diabetologi36, 741–744 (1993). ArticleCAS Google Scholar
Gutniak, M., Orskov, C., Holst, J.J.B. & Efendic, S. Antidiabetogenic effect of glucagon-like peptide-1 (7–36)amide in normal subjects and patients with diabetes mellitus. N. Engl.J. Med.326, 1316–1322 (1992). ArticleCAS Google Scholar
Dupre, J. et al> Glucagon-like peptide I reduces postprandial glycemic excursions in IDDM. Diabetes44, 626–630 (1995). ArticleCAS Google Scholar
Thorens, B. Expression cloning of the pancreatic B cell receptor for the gluco-in-cretin hormone glucagon-like peptide 1. Proc. Natl. Acad. Sci. USA89, 8641–8645 (1992). ArticleCAS Google Scholar
Willms, B. et al> Gastric emptying, glucose responses, and insulin secretion after liquid test meal: Effects of exogenous glucagon-like peptide-1 (GLP-1)-(7–36)amide in type 2 (non-insulin-dependent) diabetic patients. J. Clin. Endocrinol. Metab.81, 327–332 (1996). CASPubMed Google Scholar
D' Alessio, D.A., Kahn, S.E., Leusner, C.R. & Ensinck, J.W. Glucagon-like peptide 1 enhances glucose tolerance both by stimulation of insulin release and by increasing insulin-independent glucose disposal. J. Clin. Invest.93, 2263–2266 (1994). ArticleCAS Google Scholar
D' Alessio, D.A., Prigeon, R.L. .& Ensinck, J.W. Enteral enhancement of glucose disposition by both insulin-dependent and insulin-independent processes — A physiological role of glucagon-like peptide I. Diabetes44, 1433–1437 (1995). ArticleCAS Google Scholar
Toft-Nielsen, M., Madsbad, S. & Holst, J.J. The effect of glucagon-like peptide 1 (GLP-1) on glucose elimination in healthy subjects depends on the pancreatic glucoregul tory hormones. Diabetes45, 552–556 (1996). ArticleCAS Google Scholar
Thorens, B. et al. Cloning and functional expression of the human islet GLP-1 receptor: Demonstration that exendin-4 is an agonist and exendin-(9–39) an antagonist of the receptor. Diabetes42, 1678–1682 (1993). ArticleCAS Google Scholar
Gremlich, S. et al. Cloning, functional expression, and chromosomal localization of the human pancreatic islet glucose-dependent insulinotropic polypeptide receptor. Diabetes44, 1202–1208 (1995). ArticleCAS Google Scholar
Drucker, D.J., Philippe, J., Mojsov, S., Chick, W.L. & Habener, J.F. Glucagon-like peptide I stimulates insulin gene expression and increases cyclic AMP levels in a rat islet cell line. Proc. Natl. Acad. Sci. USA84, 3434–3438 (1987). ArticleCAS Google Scholar
D' Alessio, D.A. et al. Elimination of the action of glucagon-like peptide 1 causes an impairment of glucose tolerance after nutrient ingestion by healthy ba boons. J. Clin. Invest.97, 133–138 (1996). ArticleCAS Google Scholar
Ritzel, R., Orskov, C., Holst, J.J. & Nauck, M.A., rmacokinetic, insulinotropic, and glucagonostatic properties of GLP-1 [7–36amide] after subcutaneous injection in he althy volunteers: Dose-response-relationships. Diabetologia38, 720–725 (1995). ArticleCAS Google Scholar
Hoosein, N.M. & Gurd, R.S. Human glucagon-like peptides 1 and 2 activate rat brain adenylate cyclase. FEBS Lett.178, 83–86 (1984). ArticleCAS Google Scholar
Kanse, S.M., Kreymann, B., Ghatei, M.A. & Bloom, S.R. Identification and characterization of glucagon-like peptide-1 7–36amide-binding sites in the rat brain and lung. FEBS Lett.241, 209–212 (1988). ArticleCAS Google Scholar
Campos, R.V., Lee, Y.C. & Drucker, D.J. Divergent tissue-specific and development al expression of receptors for glucagon and glucagon-like peptide-1 in the mouse. Endocrinology134, 2156–2164 (1994). ArticleCAS Google Scholar
Wei, Y. & Mojsov, S. Tissue-specific expression of the human receptor for glucagon-like peptide 1: Brain, heart and pancreatic forms have the same deduced amino acid sequences. FEBS Lett.358, 219–224 (1995). ArticleCAS Google Scholar
Erickson, J.C., Clegg, K.E. & Palmiter, R.D. Sensitivity to leptin and susceptibility to seizures of mice lacking neuropeptide Y. Nature381, 415–418 (1996). ArticleCAS Google Scholar
Egan, J.M. Montrose-Rafizadeh, C., Wang, Y., Bernier, M. & Roth, J. Glucagon-like peptide-1(7–36)amide (GLP-1) enhances insulin-stimulated glucose metabolism in 3T3-L1 adipocytes: One of several potential extrapancreatic sites of GLP-1 action. Endocrinology135, 2070–2075 (1994). ArticleCAS Google Scholar
Villanuev -Penacarrillo, M. L., Alcántar, A.I., Clemente, F., Delgado, E. & Valverde, I. Potent glycogenic effect of GLP-1 (7–36)amide in rat skeletal muscle. Diabetologi37, 1163–1166 (1994). Article Google Scholar
Hvidberg Nielsen, M.T., Hilsted, J., Orskov, C. & Holst, J.J. Effect of glucagon-like peptide-1 (proglucgon 78–107amide) on hepatic glucose production in healthy man. Metabolism43, 104–108 (1994). Article Google Scholar
Wheeler, M.B. et al. Functional expression of the rat glucagon-like peptide-I receptor: Evidence for coupling to both adenylyl cyclase and phospholipase-C. Endocrinology133, 57–62 (1993). ArticleCAS Google Scholar
Tybulewicz, V.L.J., Crawfor, C.E. Jackson, P.K., Bronson, R.T. & Mulligan, R.C. Neonatal lethality and lymphopenia in mice with a homozygous disruption of the c-_abl_proto-oncogene. Cell65, 1153–1163 (1991). ArticleCAS Google Scholar
Nagy Rossant, J., Nagy, R.W. & Roder, J.C. Derivation of completely cell culture-derived mice from early passage embryonic stem cells. Proc. Natl. Acad. Sci. USA90, 8424–8428 (1993). Article Google Scholar
Nagy, A. & Rossant, J. Production of completely ES cell-derived fetuses. in Gene Ta rgeting: Practic lapproach, (ed. Joyner, A.L.) 147–178 (Oxford Univ. Press, Oxford, 1993). Google Scholar
Wurst, W. & Joyner, A.L. Production of targeted embryonic stem cell clones. in Gene Targeting: Practical Approach, (ed. Joyner, A.L.) 33–61 (Oxford Univ. Press, Oxford, 1993). Google Scholar
Brubaker, P.L., Lee, Y.C. & Drucker, D.J. Alterations in proglucagon processing and inhibition of proglucagon gene expression in glucagon-SV40 T antigen transgenic mice. J. Biol. Chem.267, 20728–20733 (1992). CASPubMed Google Scholar
Akesson, T.R., Mantyh, P.W., Mantyh, C.R., Matt, D.W. & Micevych, P.E. Estrous cyclicity of 125I-cholecystokinin octapeptide binding in the ventromedial hypothalamic nucleus. Evidence for downmodulation by estrogen. Neuroendocrinology45, 257–262 (1987). ArticleCAS Google Scholar
Heinrichs, S.C. et al. Endogenous corticotropin releasing factor modulates feeding induced by neuropeptide Y or a tail-pinch stressor. Peptides13, 879–884 (1992). ArticleCAS Google Scholar