NFAT and Osterix cooperatively regulate bone formation (original) (raw)

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Acknowledgements

We are grateful to T. W. Mak and L. Glimcher for providing Nfatc1 −/− and Nfatc2 −/− mice. We thank G. Karsenty, K. Imamura, M.A. Brown, RNAi Co., Ltd., and Fujisawa Pharmaceutical Co., Ltd. for providing plasmids and reagents. We also thank M. Noda, I. Morita, A. Izumi, T. Kohro, H. Murayama, T. Hongo, K. Sato, M. Shinohara, K. Nishikawa, H.J. Göber, S. Harumiya, A. Suematsu, Y. Kim, S. Ochi, M. Isobe, J. Hirooka, N. Kumasaki and I. Kawai for discussion and technical assistance. This work was supported in part by PRESTO and SORST programs of JST, grants for Genome Network Project from Ministry of Education, Culture, Sports, Science, and Technology of Japan (MEXT), grants for the 21st century COE program, Grants-in-Aid for Scientific Research from Japan Society for the Promotion of Science and MEXT, Health Sciences Research Grants from the Ministry of Health, Labour and Welfare of Japan, grants from the Mitsubishi Foundation, the Kato Trust for Nambyo Research, Takeda Science Foundation, Daiwa Securities Health Foundation, the Naito Foundation, Kowa Life Science Foundation, Suzuken Memorial Foundation, Kato Memorial Bioscience Foundation, Inamori Foundation, Uehara Memorial Foundation and the Nakajima Foundation.

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Authors and Affiliations

  1. Department of Cell Signaling, Graduate School, Tokyo Medical and Dental University, Yushima 1-5-45, Bunkyo-ku, Tokyo, 113-8549, Japan
    Takako Koga, Masataka Asagiri & Hiroshi Takayanagi
  2. SORST, Japan Science and Technology Agency (JST), Honcho 4-1-8, Kawaguchi, Saitama, 332-0012, Japan
    Takako Koga, Masataka Asagiri & Hiroshi Takayanagi
  3. Department of Surgery, Graduate School of Medicine, University of Tokyo, Hongo 7-3-1, Bunkyo-ku, Tokyo, 113-8655, Japan
    Yuichi Matsui
  4. Department of Molecular Biology and Medicine, Research Center for Advanced Science and Technology, University of Tokyo, Komaba 4-6-1, Meguro-ku, Tokyo, 153-8904, Japan
    Yuichi Matsui & Tatsuhiko Kodama
  5. Department of Molecular Genetics, M.D. Anderson Cancer Center, University of Texas, 1515 Holcombe Boulevard, Houston, 77030, Texas, USA
    Benoit de Crombrugghe
  6. Department of Molecular Pharmacology, Medical Research Institute, Tokyo Medical and Dental University, Kanda-Surugadai 2-3-10, Chiyoda-ku, Tokyo, 101-0062, Japan
    Kazuhisa Nakashima
  7. COE Program for Frontier Research on Molecular Destruction and Reconstruction of Tooth and Bone,
    Takako Koga, Masataka Asagiri, Kazuhisa Nakashima & Hiroshi Takayanagi

Authors

  1. Takako Koga
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  2. Yuichi Matsui
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  3. Masataka Asagiri
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  4. Tatsuhiko Kodama
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  5. Benoit de Crombrugghe
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  6. Kazuhisa Nakashima
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  7. Hiroshi Takayanagi
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Correspondence toHiroshi Takayanagi.

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The authors declare no competing financial interests.

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Koga, T., Matsui, Y., Asagiri, M. et al. NFAT and Osterix cooperatively regulate bone formation.Nat Med 11, 880–885 (2005). https://doi.org/10.1038/nm1270

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