Chronic stress promotes tumor growth and angiogenesis in a mouse model of ovarian carcinoma (original) (raw)

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A Correction to this paper has been published: https://doi.org/10.1038/s41591-021-01566-5

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Acknowledgements

The authors thank I.J. Fidler, J. Price, C. Bucana, G. Gallick and A. Johnson for their helpful input and discussions regarding this work. We thank D. Reynolds for assistance with immunohistochemistry. We also thank J. Johnson and E. Schrock for assistance with manuscript preparation. This work was supported by US National Institutes of Health (NIH) grants (CA-11079301 and CA-10929801), the Donna Marie Cimitile-Fotheringham Award for Ovarian Cancer Research, the U.T. M.D. Anderson Ovarian Cancer SPORE (2P50 CA083639-06A1), and a Program Project Development Grant from the Ovarian Cancer Research Fund, Inc. to A.K.S., NIH grant CA-104825 to S.K.L., and NIH grant A152737 to S.W.C.

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Author notes

  1. Premal H Thaker, Liz Y Han and Aparna A Kamat: These authors contributed equally to this work.

Authors and Affiliations

  1. Department of Gynecologic Oncology, University of Texas (U.T.) M.D. Anderson Cancer Center, 1155 Herman Pressler, Unit 1362, Houston, 77030, Texas, USA
    Premal H Thaker, Liz Y Han, Aparna A Kamat, Chunhua Lu, Nicholas B Jennings, Guillermo Armaiz-Pena, William M Merritt, Yvonne G Lin, Lingegowda S Mangala, Tae Jin Kim, Robert L Coleman, Charles N Landen, Yang Li, David M Gershenson & Anil K Sood
  2. Division of Hematology-Oncology, Department of Medicine, 11-934 Factor Building, University of California Los Angeles (UCLA) School of Medicine, Los Angeles, 90095, California, USA
    Jesusa M Arevalo, Rie Takahashi & Steven W Cole
  3. Department of Imaging Physics, U.T. M.D. Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, 77030, Texas, USA
    James A Bankson
  4. Department of Experimental Diagnostic Imaging, U.T. M.D. Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, 77030, Texas, USA
    Murali Ravoori & Vikas Kundra
  5. Department of Experimental Therapeutics, U.T. M.D. Anderson Cancer Center, 8000 El Rio Street, Houston, 77054, Texas, USA
    Edward Felix & Robert A Newman
  6. Department of Experimental Therapeutics, U.T. M.D. Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, 77030, Texas, USA
    Angela M Sanguino & Gabriel Lopez-Berestein
  7. Department of Cancer Biology, U.T. M.D. Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, 77030, Texas, USA
    Mary Lloyd & Anil K Sood
  8. Department of Diagnostic Radiology, U.T. M.D. Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, 77030, Texas, USA
    Vikas Kundra
  9. Department of Psychology, University of Iowa, E228 Seashore Hall, Iowa City, 52241, Iowa, USA
    Susan K Lutgendorf

Authors

  1. Premal H Thaker
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  2. Liz Y Han
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  3. Aparna A Kamat
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  4. Jesusa M Arevalo
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  5. Rie Takahashi
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  6. Chunhua Lu
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  7. Nicholas B Jennings
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  8. Guillermo Armaiz-Pena
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  9. James A Bankson
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  10. Murali Ravoori
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  11. William M Merritt
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  12. Yvonne G Lin
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  13. Lingegowda S Mangala
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  14. Tae Jin Kim
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  15. Robert L Coleman
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  16. Charles N Landen
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  17. Yang Li
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  18. Edward Felix
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  19. Angela M Sanguino
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  20. Robert A Newman
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  21. Mary Lloyd
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  22. David M Gershenson
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  23. Vikas Kundra
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  24. Gabriel Lopez-Berestein
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  25. Susan K Lutgendorf
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  26. Steven W Cole
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  27. Anil K Sood
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Contributions

P.H.T., L.Y.H. and A.A.K. designed and performed experiments and wrote portions of the manuscript. J.M.A. and R.T. designed and performed VEGF transcription and promoter assays and edited the manuscript. C.L., N.B.J., G.A.-P., W.M.M., Y.G.L., M.L., L.S.M., T.J.K., C.N.L. and Y.L. designed and performed experiments and edited the manuscript. E.F. and R.A.N. designed and performed catecholamine analyses and edited the manuscript. J.A.B., M.R. and V.K. designed and performed the imaging experiments and edited the manuscript. A.M.S. and G.L.-B. performed siRNA incorporations and edited the manuscript. R.L.C. and D.M.G. performed statistical analyses and edited the manuscript. S.K.L., S.W.C. and A.K.S. designed the overall study, analyzed data and edited the manuscript.

Corresponding author

Correspondence toAnil K Sood.

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The authors declare no competing financial interests.

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Thaker, P., Han, L., Kamat, A. et al. Chronic stress promotes tumor growth and angiogenesis in a mouse model of ovarian carcinoma.Nat Med 12, 939–944 (2006). https://doi.org/10.1038/nm1447

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