Retinaldehyde represses adipogenesis and diet-induced obesity (original) (raw)

• Paydas, S. et al. Vasculitis associated with all trans retinoic acid (ATRA) in a case with acute promyelocytic leukemia. Leuk. Lymphoma 44, 547–548 (2003).
  Article CAS Google Scholar
• Redlich, C.A. et al. Effect of long-term β-carotene and vitamin A on serum cholesterol and triglyceride levels among participants in the Carotene and Retinol Efficacy Trial (CARET). Atherosclerosis 143, 427–434 (1999).
  Article CAS Google Scholar
• Rapola, J.M. et al. Randomised trial of α-tocopherol and β-carotene supplements on incidence of major coronary events in men with previous myocardial infarction. Lancet 349, 1715–1720 (1997).
  Article CAS Google Scholar
• Napoli, J.L. Retinoic acid: its biosynthesis and metabolism. Prog. Nucleic Acid Res. Mol. Biol. 63, 139–188 (1999).
  Article CAS Google Scholar
• Duester, G., Mic, F.A. & Molotkov, A. Cytosolic retinoid dehydrogenases govern ubiquitous metabolism of retinol to retinaldehyde followed by tissue-specific metabolism to retinoic acid. Chem. Biol. Interact. 143–144, 201–210 (2003).
  Article Google Scholar
• Chambon, P. A decade of molecular biology of retinoic acid receptors. FASEB J. 10, 940–954 (1996).
  Article CAS Google Scholar
• Heyman, R.A. et al. 9-cis retinoic acid is a high affinity ligand for the retinoid X receptor. Cell 68, 397–406 (1992).
  Article CAS Google Scholar
• Shulman, A.I. & Mangelsdorf, D.J. Retinoid x receptor heterodimers in the metabolic syndrome. N. Engl. J. Med. 353, 604–615 (2005).
  Article CAS Google Scholar
• Fu, M. et al. A nuclear receptor atlas: 3T3–L1 adipogenesis. Mol. Endocrinol. 19, 2437–2450 (2005).
  Article CAS Google Scholar
• Xue, J.C., Schwarz, E.J., Chawla, A. & Lazar, M.A. Distinct stages in adipogenesis revealed by retinoid inhibition of differentiation after induction of PPARγ. Mol. Cell. Biol. 16, 1567–1575 (1996).
  Article CAS Google Scholar
• Kikonyogo, A., Abriola, D.P., Dryjanski, M. & Pietruszko, R. Mechanism of inhibition of aldehyde dehydrogenase by citral, a retinoid antagonist. Eur. J. Biochem. 262, 704–712 (1999).
  Article CAS Google Scholar
• Ress, N.B. et al. Toxicology and carcinogenesis studies of microencapsulated citral in rats and mice. Toxicol. Sci. 71, 198–206 (2003).
  Article CAS Google Scholar
• Duester, G. Families of retinoid dehydrogenases regulating vitamin A function: production of visual pigment and retinoic acid. Eur. J. Biochem. 267, 4315–4324 (2000).
  Article CAS Google Scholar
• Molotkov, A. & Duester, G. Genetic evidence that retinaldehyde dehydrogenase Raldh1 (Aldh1a1) functions downstream of alcohol dehydrogenase Adh1 in metabolism of retinol to retinoic acid. J. Biol. Chem. 278, 36085–36090 (2003).
  Article CAS Google Scholar
• von Lintig, J. & Wyss, A. Molecular analysis of vitamin A formation: cloning and characterization of β-carotene 15,15′-dioxygenases. Arch. Biochem. Biophys. 385, 47–52 (2001).
  Article CAS Google Scholar
• Lakshman, M.R., Mychkovsky, I. & Attlesey, M. Enzymatic conversion of all-trans-β-carotene to retinal by a cytosolic enzyme from rabbit and rat intestinal mucosa. Proc. Natl. Acad. Sci. USA 86, 9124–9128 (1989).
  Article CAS Google Scholar
• Vogel, S. et al. Characterization of a new member of the fatty acid-binding protein family that binds all-trans-retinol. J. Biol. Chem. 276, 1353–1360 (2001).
  Article CAS Google Scholar
• Berni, R., Clerici, M., Malpeli, G., Cleris, L. & Formelli, F. Retinoids: in vitro interaction with retinol-binding protein and influence on plasma retinol. FASEB J. 7, 1179–1184 (1993).
  Article CAS Google Scholar
• Yu, S. et al. Adipocyte-specific gene expression and adipogenic steatosis in the mouse liver due to peroxisome proliferator-activated receptor γ1 (PPARγ1) overexpression. J. Biol. Chem. 278, 498–505 (2003).
  Article CAS Google Scholar
• Iwaki, M. et al. Induction of adiponectin, a fat-derived antidiabetic and antiatherogenic factor, by nuclear receptors. Diabetes 52, 1655–1663 (2003).
  Article CAS Google Scholar
• Repa, J.J., Hanson, K.K. & Clagett-Dame, M. All-trans-retinol is a ligand for the retinoic acid receptors. Proc. Natl. Acad. Sci. USA 90, 7293–7297 (1993).
  Article CAS Google Scholar
• Berger, J.P. et al. Distinct properties and advantages of a novel peroxisome proliferator-activated protein γ selective modulator. Mol. Endocrinol. 17, 662–676 (2003).
  Article CAS Google Scholar
• Canan Koch, S.S. et al. Synthesis of retinoid X receptor-specific ligands that are potent inducers of adipogenesis in 3T3–L1 cells. J. Med. Chem. 42, 742–750 (1999).
  Article CAS Google Scholar
• Imai, T., Jiang, M., Chambon, P. & Metzger, D. Impaired adipogenesis and lipolysis in the mouse upon selective ablation of the retinoid X receptor α mediated by a tamoxifen-inducible chimeric Cre recombinase (Cre-ERT2) in adipocytes. Proc. Natl. Acad. Sci. USA 98, 224–228 (2001).
  CAS PubMed Google Scholar
• Green, H. & Meuth, M. An established pre-adipose cell line and its differentiation in culture. Cell 3, 127–133 (1974).
  Article CAS Google Scholar
• Puigserver, P. et al. A cold-inducible coactivator of nuclear receptors linked to adaptive thermogenesis. Cell 92, 829–839 (1998).
  Article CAS Google Scholar
• He, W. et al. Adipose-specific peroxisome proliferator-activated receptor γ knockout causes insulin resistance in fat and liver but not in muscle. Proc. Natl. Acad. Sci. USA 100, 15712–15717 (2003).
  Article CAS Google Scholar
• Kubota, N. et al. Pioglitazone ameliorates insulin resistance and diabetes by both adiponectin dependent and independent pathway. J. Biol. Chem. 281, 8748–8755 (2006).
  Article CAS Google Scholar
• Yang, Q. et al. Serum retinol binding protein 4 contributes to insulin resistance in obesity and type 2 diabetes. Nature 436, 356–362 (2005).
  Article CAS Google Scholar
• Lee, S., Bacha, F., Gungor, N. & Arslanian, S.A. Racial differences in adiponectin in youth: relationship to visceral fat and insulin sensitivity. Diabetes Care 29, 51–56 (2006).
  Article CAS Google Scholar
• Nawrocki, A.R. et al. Mice lacking adiponectin show decreased hepatic insulin sensitivity and reduced responsiveness to peroxisome proliferator-activated receptor γ agonists. J. Biol. Chem. 281, 2654–2660 (2006).
  Article CAS Google Scholar
• Maeda, K. et al. Adipocyte/macrophage fatty acid binding proteins control integrated metabolic responses in obesity and diabetes. Cell Metab. 1, 107–119 (2005).
  Article CAS Google Scholar
• Graham, T.E. et al. Retinol-binding protein 4 and insulin resistance in lean, obese, and diabetic subjects. N. Engl. J. Med. 354, 2552–2563 (2006).
  Article CAS Google Scholar
• Hallsten, K. et al. Rosiglitazone but not metformin enhances insulin- and exercise-stimulated skeletal muscle glucose uptake in patients with newly diagnosed type 2 diabetes. Diabetes 51, 3479–3485 (2002).
  Article CAS Google Scholar
• Yamauchi, T. et al. Inhibition of RXR and PPARγ ameliorates diet-induced obesity and type 2 diabetes. J. Clin. Invest. 108, 1001–1013 (2001).
  Article CAS Google Scholar
• Cavasotto, C.N. et al. Determinants of retinoid X receptor transcriptional antagonism. J. Med. Chem. 47, 4360–4372 (2004).
  Article CAS Google Scholar
• Sell, H. et al. Peroxisome proliferator-activated receptor γ agonism increases the capacity for sympathetically mediated thermogenesis in lean and ob/ob mice. Endocrinology 145, 3925–3934 (2004).
  Article CAS Google Scholar
• Fliers, E. et al. White adipose tissue: getting nervous. J. Neuroendocrinol. 15, 1005–1010 (2003).
  Article CAS Google Scholar
• Ziouzenkova, O. et al. Lipolysis of triglyceride-rich lipoproteins generates PPAR ligands: evidence for an antiinflammatory role for lipoprotein lipase. Proc. Natl. Acad. Sci. USA 100, 2730–2735 (2003).
  Article CAS Google Scholar
• Xie, Y., Lashuel, H.A., Miroy, G.J., Dikler, S. & Kelly, J.W. Recombinant human retinol-binding protein refolding, native disulfide formation, and characterization. Protein Expr. Purif. 14, 31–37 (1998).
  Article Google Scholar
• Cogan, U., Kopelman, M., Mokady, S. & Shinitzky, M. Binding affinities of retinol and related compounds to retinol binding proteins. Eur. J. Biochem. 65, 71–78 (1976).
  Article CAS Google Scholar
• Weir, J.B. New methods for calculating metabolic rate with special reference to protein metabolism. J. Physiol. (Lond.) 109, 1–9 (1949).
  Article Google Scholar
• Szatmari, I. et al. PPARγ controls CD1d expression by turning on retinoic acid synthesis in developing human dendritic cells. J. Exp. Med. 203, 2351–2362 (2006).
  Article CAS Google Scholar