Clearance of amyloid-β by circulating lipoprotein receptors (original) (raw)

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Acknowledgements

This work was supported by US National Institutes of Health (NIH) grants R37 AG023084 and R37 NS34467 to B.V.Z. and Washington University St. Louis Alzheimer's Disease Research Center grant P50 AG05681.

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Author notes

  1. Abhay Sagare, Rashid Deane and Robert D Bell: These authors contributed equally to this work.

Authors and Affiliations

  1. Department of Neurosurgery, Frank P. Smith Laboratory for Neuroscience and Neurosurgical Research, University of Rochester Medical School, Rochester, 14642, New York, USA
    Abhay Sagare, Rashid Deane, Robert D Bell, Bradley Johnson, Katie Hamm, Andrew Marky, Zhenhua Wu, David Perlmutter, Mireia Coma, Zhihui Zhong & Berislav V Zlokovic
  2. Department of Hematology, Laboratory for Thrombosis and Haemostasis, University Medical Center Utrecht, Utrecht, 3584 CX, The Netherlands
    Ronan Pendu & Peter J Lenting
  3. Department of Environmental Medicine, Neurobehavioral Facility Laboratory, University of Rochester Medical School, Rochester, New York, USA
    Troy Zarcone
  4. Department of Psychiatry, B8134, Washington University School of Medicine, St. Louis, 63110, Missouri, USA
    Alison Goate & Kevin Mayo

Authors

  1. Abhay Sagare
  2. Rashid Deane
  3. Robert D Bell
  4. Bradley Johnson
  5. Katie Hamm
  6. Ronan Pendu
  7. Andrew Marky
  8. Peter J Lenting
  9. Zhenhua Wu
  10. Troy Zarcone
  11. Alison Goate
  12. Kevin Mayo
  13. David Perlmutter
  14. Mireia Coma
  15. Zhihui Zhong
  16. Berislav V Zlokovic

Contributions

A.S. conducted and performed in vivo studies in wild-type and APP+/sw (APPsw+/−) mice. R.D. conducted and performed pharmacokinetic and cerebral blood flow studies and work on the human study protocol. R.D.B. conducted and performed in vitro ligand binding assays and Aβ immunostaining studies. B.J. performed the oxidized sLRP assay and sLRP ELISA assay. K.H. performed in vivo studies in wild-type mice. R.P. purified recombinant LRP-IV. A.M. performed cholesterol and apoE assays. P.J.L. supervised R.P. and provided LRP-IV. Z.W. conducted and performed memory tests in mice. T.Z. performed approach and operant learning test in mice. D.P. performed active tPA and pro-MMP-9 assays. A.G. and K.M. performed LRP polymorphism studies. M.C. performed immunoprecipitation of oxidized proteins. Z.Z. performed Prussian blue staining. B.V.Z. designed the entire study, supervised all portions of the study and wrote the manuscript.

Corresponding author

Correspondence toBerislav V Zlokovic.

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Competing interests

B.V.Z. is Scientific Founder and Program Director of Socratech LLC, a startup biotechnology company with a mission to develop therapeutics for Alzheimer's disease, stroke and other neurodegenerative disorders, and owns shares in the company. He does not receive direct financial compensation from Socratech LLC.

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Sagare, A., Deane, R., Bell, R. et al. Clearance of amyloid-β by circulating lipoprotein receptors.Nat Med 13, 1029–1031 (2007). https://doi.org/10.1038/nm1635

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