Cytokine traps: multi-component, high-affinity blockers of cytokine action (original) (raw)
van Deventer, S.J. Anti-TNF antibody treatment of Crohn's disease. Ann. Rheum. Dis.58 (Suppl. 1), I114–1120 (1999). ArticleCAS Google Scholar
Richard-Miceli, C. & Dougados, M. Tumour necrosis factor-α blockers in rheumatoid arthritis: Review of the clinical experience. Biodrugs15, 251–259 (2001). ArticleCAS Google Scholar
Elliott, M.J. et al. Treatment of rheumatoid arthritis with chimeric monoclonal antibodies to tumor necrosis factor α. Arthritis Rheum.36, 1681–1690 (1993). ArticleCAS Google Scholar
Goldenberg, M.M. Etanercept, a novel drug for the treatment of patients with severe, active rheumatoid arthritis. Clin. Ther.21, 75–87 (1999). ArticleCAS Google Scholar
Mohler, K.M. et al. Soluble tumor necrosis factor (TNF) receptors are effective therapeutic agents in lethal endotoxemia and function simultaneously as both TNF carriers and TNF antagonists. J. Immunol.151, 1548–1561 (1993). CASPubMed Google Scholar
Bresnihan, B. et al. Treatment of rheumatoid arthritis with recombinant human interleukin-1 receptor antagonist. Arthritis Rheum.41, 2196–2204 (1998). ArticleCAS Google Scholar
Cohen, S., Hurd, E. & Cush, J. Treatment of interleukin-1 receptor antagonist in combination with methotrexate in rheumatoid arthritis patients. Arthritis Rheum.42, S273 (1999). Article Google Scholar
Nuki, G., Rozman, B. & Pavelka, K. Interleukin-1 receptor antagonist continues to demonstrate clinical improvement in rheumatoid arthritis. Arthritis Rheum.40, S224 (1997). Google Scholar
Campion, G.V., Lebsack, M.E., Lookabaugh, J., Gordon, G. & Catalano, M. Dose-range and dose-frequency study of recombinant human interleukin-1 receptor antagonist in patients with rheumatoid arthritis. The IL-1Ra Arthritis Study Group. Arthritis Rheum.39, 1092–1101 (1996). ArticleCAS Google Scholar
Bresnihan, B. The prospect of treating rheumatoid arthritis with recombinant human interleukin-1 receptor antagonist. Biodrugs15, 87–97 (2001). ArticleCAS Google Scholar
Borish, L.C. et al. Interleukin-4 receptor in moderate atopic asthma. A phase I/II randomized, placebo-controlled trial. Am. J. Respir. Crit. Care Med.160, 1816–1823 (1999). ArticleCAS Google Scholar
Borish, L.C. et al. Efficacy of soluble IL-4 receptor for the treatment of adults with asthma. J. Allergy Clin. Immunol.107, 963–970 (2001). ArticleCAS Google Scholar
Bataille, R. et al. Biologic effects of anti-interleukin-6 murine monoclonal antibody in advanced multiple myeloma. Blood86, 685–691 (1995). CASPubMed Google Scholar
Haddad, E. et al. Treatment of B-lymphoproliferative disorder with a monoclonal anti-interleukin-6 antibody in 12 patients: a multicenter phase 1-2 clinical trial. Blood97, 1590–1597 (2001). ArticleCAS Google Scholar
Beck, J.T. et al. Brief report: Alleviation of systemic manifestations of Castleman's disease by monoclonal anti-interleukin-6 antibody. N. Engl. J. Med.330, 602–605 (1994). ArticleCAS Google Scholar
Legouffe, E. et al. Human anti-mouse antibody response to the injection of murine monoclonal antibodies against IL-6. Clin. Exp. Immunol.98, 323–329 (1994). ArticleCAS Google Scholar
Carpenter, L.R., Yancopoulos, G.D. & Stahl, N. General mechanisms of cytokine receptor signaling. Adv. Protein Chem.52, 109–140 (1999). Article Google Scholar
Davis, S. et al. LIFR β and gp130 as heterodimerizing signal transducers of the tripartite CNTF receptor. Science260, 1805–1808 (1993). ArticleCAS Google Scholar
Stahl, N. & Yancopoulos, G.D. The alphas, betas, and kinases of cytokine receptor complexes. Cell74, 587–590 (1993). ArticleCAS Google Scholar
Taga, T. et al. Interleukin-6 triggers the association of its receptor with a possible signal transducer, gp130. Cell58, 573–581 (1989). ArticleCAS Google Scholar
Dinarello, C.A. Biologic basis for interleukin-1 in disease. Blood87, 2095–2147 (1996). CASPubMed Google Scholar
van den Berg, W.B., Joosten, L.A., Helsen, M. & van de Loo, F.A. Amelioration of established murine collagen-induced arthritis with anti-IL-1 treatment. Clin. Exp. Immunol.95, 237–243 (1994). ArticleCAS Google Scholar
Reimers, J. Interleukin-1b induced transient diabetes mellitus in rats. Danish Med. Bull.45, 157–180 (1998). CASPubMed Google Scholar
van den Berg, W.B. Joint inflammation and cartilage destruction may occur uncoupled. Springer Semin. Immunopathol.20, 149–164 (1998). ArticleCAS Google Scholar
Joosten, L.A., Helsen, M.M., van de Loo, F.A. & van den Berg, W.B. Anticytokine treatment of established type II collagen-induced arthritis in DBA/1 mice. A comparative study using anti-TNF α, anti- IL-1 α/β, and IL-1Ra. Arthritis Rheum.39, 797–809 (1996). ArticleCAS Google Scholar
Cieslewicz, G. et al. The late, but not early, asthmatic response is dependent on IL-5 and correlates with eosinophil infiltration. J. Clin. Invest.104, 301–308 (1999). ArticleCAS Google Scholar
Wills-Karp, M. Immunologic basis of antigen-induced airway hyperresponsiveness. Annu. Rev. Immunol.17, 255–281 (1999). ArticleCAS Google Scholar
Gundel, R. et al. IL-4 induced leucocyte trafficking in cynomolgus monkeys: correlation with expression of adhesion molecules and chemokine generation. Clin. Exp. Allergy26, 719–729 (1996). ArticleCAS Google Scholar
Foote, J. & Eisen, H.N. Kinetic and affinity limits on antibodies produced during immune responses. Proc. Natl. Acad. Sci. USA92, 1254–1256 (1995). ArticleCAS Google Scholar
Guler, H.-P. et al. A phase 1, single dose escalation study of IL-1 trap in patients with rheumatoid arthritis. Arthritis Rheum.44, S370 (2001).
Wills-Karp, M. et al. Interleukin-13: central mediator of allergic asthma. Science282, 2258–2261 (1998). ArticleCAS Google Scholar
Grunig, G. et al. Requirement for IL-13 independently of IL-4 in experimental asthma. Science282, 2261–2263 (1998). ArticleCAS Google Scholar
Coyle, A.J. et al. Interleukin-4 is required for the induction of lung Th2 mucosal immunity. Am. J. Respir. Cell Mol. Biol.13, 54–59 (1995). ArticleCAS Google Scholar
Holash, J. et al. VEGF-trap: A VEGF blocker with potent antitumor effects. Proc. Natl. Acad. Sci. USA99, 11393–11398 (2002). ArticleCAS Google Scholar
Kim, E.S. et al. Potent VEGF blockade causes regression of coopted vessels in a model of neuroblastoma. Proc. Natl. Acad. Sci. USA99, 11399–11404 (2002). ArticleCAS Google Scholar
Joosten, L.A., Helsen, M.M. & van den Berg, W.B. Accelerated onset of collagen-induced arthritis by remote inflammation. Clin. Exp. Immunol.97, 204–211 (1994). ArticleCAS Google Scholar
Wooley, P.H. et al. The effect of an interleukin-1 receptor antagonist protein on type II collagen-induced arthritis and antigen-induced arthritis in mice. Arthritis Rheum.36, 1305–1314 (1993). ArticleCAS Google Scholar