T-cell-mediated cytotoxicity toward platelets in chronic idiopathic thrombocytopenic purpura (original) (raw)

Nature Medicine volume 9, pages 1123–1124 (2003)Cite this article

Abstract

Chronic idiopathic thrombocytopenic purpura (ITP) is a bleeding disorder that is characterized by increased platelet destruction and is believed to be autoantibody mediated. In this study, CD3+ T cells from ITP patients had increased expression of genes involved in cell-mediated cytotoxicity. In addition, cytotoxic cell-mediated lysis of autologous platelets was shown in active ITP. Our data suggest that T-cell-mediated cytotoxicity is an alternative mechanism for platelet destruction in ITP.

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References

  1. Harrington, W.J., Minnich V., Hollingsworth J.W. & Moore, J.C. J. Lab. Clin. Med. 38, 1–10 (1951).
    CAS PubMed Google Scholar
  2. Cines, D.B. & Blanchette, V.S. N. Engl. J. Med. 346, 995–1008 (2002).
    Article Google Scholar
  3. Warner, M.N., Moore, J.C., Warkentin, T.E., Santos, A.V. & Kelton, J.G. Br. J. Haematol. 104, 442–447 (1999).
    Article CAS Google Scholar
  4. Brighton, T.A., Evans, S., Castaldi, P.A., Chesterman, C.N. & Chong, B.H. Blood 88, 194–201 (1996).
    CAS PubMed Google Scholar
  5. Semple, J.W. et al. Blood 87, 4245–4254 (1996).
    CAS PubMed Google Scholar
  6. Hopkins, L., Davis, J., Schwartz, K. & Gerlach, J. Hum. Immunol. 63, S5 (2002).
  7. Vilches, C. & Parham, P. Annu. Rev. Immunol. 20, 217–251 (2002).
    Article CAS Google Scholar
  8. Boyington, J.C., Brooks, A.G. & Sun, P.D. Immunol. Rev. 181, 66–78 (2001).
    Article CAS Google Scholar
  9. Ozsoylu, S., Karabent, A., Irken, G. & Tuncer, M. Am. J. Hematol. 36, 82–85 (1991).
    Article CAS Google Scholar
  10. Berchtold, P. & Wenger, M. Blood 81, 1246–1250 (1993).
    CAS PubMed Google Scholar
  11. Imbach, P. et al. J. Pediatr. 118, 535–539 (1991).
    Article CAS Google Scholar
  12. Stockelberg, D., Hou, M., Jacobsson, S., Kutti, J. & Wadenvik, H. Eur. J. Haematol. 56, 72–77 (1996).
    Article CAS Google Scholar

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Acknowledgements

Grants were from the Swedish Medical Research Council (projects no. 11630, 11285 and 13141) and the IngaBritt and Arne Lundberg Forskningsstiftelse.

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Author notes

  1. Bob Olsson and Per-Ola Andersson: These authors contributed equally to this work.

Authors and Affiliations

  1. Research Center for Endocrinology and Metabolism, Sahlgrenska University Hospital, Göteborg University, Göteborg, SE-413 45, Sweden
    Bob Olsson, Margareta Jernås, Björn Carlsson & Lena M S Carlsson
  2. Department of Internal Medicine, Section of Hematology and Coagulation, Sahlgrenska University Hospital, Göteborg University, Göteborg, SE-413 45, Sweden
    Per-Ola Andersson & Hans Wadenvik
  3. Department of Clinical Chemistry and Transfusion Medicine, Sahlgrenska University Hospital, Göteborg University, Göteborg, SE-413 45, Sweden
    Stefan Jacobsson

Authors

  1. Bob Olsson
  2. Per-Ola Andersson
  3. Margareta Jernås
  4. Stefan Jacobsson
  5. Björn Carlsson
  6. Lena M S Carlsson
  7. Hans Wadenvik

Corresponding author

Correspondence toPer-Ola Andersson.

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Competing interests

The authors declare no competing financial interests.

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Olsson, B., Andersson, PO., Jernås, M. et al. T-cell-mediated cytotoxicity toward platelets in chronic idiopathic thrombocytopenic purpura.Nat Med 9, 1123–1124 (2003). https://doi.org/10.1038/nm921

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