- de Sauvage, F.J. et al. Stimulation of megakaryocytopoiesis and thrombopoiesis by the c-Mpl ligand. Nature 369, 533–538 (1994).
Article CAS PubMed Google Scholar
- Lok, S. et al. Cloning and expression of murine thrombopoietin cDNA and stimulation of platelet production in vivo. Nature 369, 565–568 (1994).
Article CAS PubMed Google Scholar
- Kaushansky, K. et al. Promotion of megakaryocyte progenitor expansion and differentiation by the c-Mpl ligand thrombopoietin. Nature 369, 568–571 (1994).
Article CAS PubMed Google Scholar
- Kuter, D.J., Beeler, D.L. & Rosenberg, R.D. The purification of megapoietin: a physiological regulator of megakaryocyte growth and platelet production. Proc. Natl. Acad. Sci. USA 91, 11104–11108 (1994).
Article CAS PubMed PubMed Central Google Scholar
- Bartley, T.D. et al. Identification and cloning of a megakaryocyte growth and development factor that is a ligand for the cytokine receptor Mpl. Cell 77, 1117–1124 (1994).
Article CAS PubMed Google Scholar
- Gurney, A.L., Carver-Moore, K., de Sauvage, F.J. & Moore, M.W. Thrombocytopenia in c-mpl-deficient mice. Science 265, 1445–1447 (1994).
Article CAS PubMed Google Scholar
- Gurney, A.L. & de Sauvage, F.J. Dissection of c-Mpl and thrombopoietin function: studies of knockout mice and receptor signal transduction. Stem Cells 14 (suppl. 1), 116–123 (1996).
Article PubMed Google Scholar
- Bunting, S. et al. Normal platelets and megakaryocytes are produced in vivo in the absence of thrombopoietin. Blood 90, 3423–3429 (1997).
CAS PubMed Google Scholar
- de Sauvage, F.J. et al. Physiological regulation of early and late stages of megakaryocytopoiesis by thrombopoietin. J. Exp. Med. 183, 651–656 (1996).
Article CAS PubMed Google Scholar
- Zucker-Franklin, D. & Philipp, C.S. Platelet production in the pulmonary capillary bed: new ultrastructural evidence for an old concept. Am. J. Pathol. 157, 69–74 (2000).
Article CAS PubMed PubMed Central Google Scholar
- Tavassoli, M. & Aoki, M. Localization of megakaryocytes in the bone marrow. Blood Cells 15, 3–14 (1989).
CAS Google Scholar
- Chen, Q., Solar, G., Eaton, D.L. & de Sauvage, F.J. IL-3 does not contribute to platelet production in c-Mpl-deficient mice. Stem Cells 16 (suppl. 2), 31–36 (1998).
Article PubMed Google Scholar
- Gainsford, T. et al. Cytokine production and function in c-mpl-deficient mice: no physiologic role for interleukin-3 in residual megakaryocyte and platelet production. Blood 91, 2745–2752 (1998).
CAS PubMed Google Scholar
- Gainsford, T. et al. The residual megakaryocyte and platelet production in c-mpl-deficient mice is not dependent on the actions of interleukin-6, interleukin-11, or leukemia inhibitory factor. Blood 95, 528–534 (2000).
CAS PubMed Google Scholar
- Hamada, T. et al. Transendothelial migration of megakaryocytes in response to stromal cell-derived factor 1 (SDF-1) enhances platelet formation. J. Exp. Med. 188, 539–548 (1998).
Article CAS PubMed PubMed Central Google Scholar
- Wang, J.F., Liu, Z.Y. & Groopman, J.E. The α-chemokine receptor CXCR4 is expressed on the megakaryocytic lineage from progenitor to platelets and modulates migration and adhesion. Blood 92, 756–764 (1998).
CAS PubMed Google Scholar
- Riviere, C. et al. Phenotypic and functional evidence for the expression of CXCR4 receptor during megakaryocytopoiesis. Blood 93, 1511–1523 (1999).
CAS PubMed Google Scholar
- Lane, W.J. et al. Stromal-derived factor 1-induced megakaryocyte migration and platelet production is dependent on matrix metalloproteinases. Blood 96, 4152–4159 (2000).
CAS PubMed Google Scholar
- Majka, M. et al. Stromal-derived factor 1 and thrombopoietin regulate distinct aspects of human megakaryopoiesis. Blood 96, 4142–4151 (2000).
CAS PubMed Google Scholar
- Konishi, H. et al. Effective prevention of thrombocytopenia in mice using adenovirus-mediated transfer of HST-1 (FGF-4) gene. J. Clin. Invest. 96, 1125–1130 (1995).
Article CAS PubMed PubMed Central Google Scholar
- Sakamoto, H. et al. Adenovirus-mediated transfer of the HST-1 (FGF4) gene induces increased levels of platelet count in vivo. Proc. Natl. Acad. Sci. USA 91, 12368–12372 (1994).
Article CAS PubMed PubMed Central Google Scholar
- Casella, I. et al. Autocrine-paracrine VEGF loops potentiate the maturation of megakaryocytic precursors through Flt1 receptor. Blood 101, 1316–1323 (2003).
Article CAS PubMed Google Scholar
- Rafii, S. et al. Isolation and characterization of human bone marrow microvascular endothelial cells: hematopoietic progenitor cell adhesion. Blood 84, 10–19 (1994).
CAS PubMed Google Scholar
- Rafii, S. et al. Human bone marrow microvascular endothelial cells support long-term proliferation and differentiation of myeloid and megakaryocytic progenitors. Blood 86, 3353–3363 (1995).
CAS PubMed Google Scholar
- Corada, M. et al. Monoclonal antibodies directed to different regions of vascular endothelial cadherin extracellular domain affect adhesion and clustering of the protein and modulate endothelial permeability. Blood 97, 1679–1684 (2001).
Article CAS PubMed Google Scholar
- Su, W.H., Chen, H.I. & Jen, C.J. Differential movements of VE-cadherin and PECAM-1 during transmigration of polymorphonuclear leukocytes through human umbilical vein endothelium. Blood 100, 3597–3603 (2002).
Article CAS PubMed Google Scholar
- Heissig, B. et al. Recruitment of stem and progenitor cells from the bone marrow niche requires MMP-9 mediated release of kit-ligand. Cell 109, 625–637 (2002).
Article CAS PubMed PubMed Central Google Scholar
- Hattori, K. et al. Placental growth factor reconstitutes hematopoiesis by recruiting VEGFR1+ stem cells from bone-marrow microenvironment. Nat. Med. 8, 841–849 (2002).
Article CAS PubMed PubMed Central Google Scholar
- Liao, F. et al. Selective targeting of angiogenic tumor vasculature by vascular endothelial-cadherin antibody inhibits tumor growth without affecting vascular permeability. Cancer Res. 62, 2567–2575 (2002).
CAS PubMed Google Scholar
- Avraham, H., Banu, N., Scadden, D.T., Abraham, J. & Groopman, J.E. Modulation of megakaryocytopoiesis by human basic fibroblast growth factor. Blood 83, 2126–2132 (1994).
CAS PubMed Google Scholar
- Avraham, H., Cowley, S., Chi, S.Y., Jiang, S. & Groopman, J.E. Characterization of adhesive interactions between human endothelial cells and megakaryocytes. J. Clin. Invest. 91, 2378–2384 (1993).
Article CAS PubMed PubMed Central Google Scholar
- Avraham, H. et al. Interaction of human bone marrow fibroblasts with megakaryocytes: role of the c-kit ligand. Blood 80, 1679–1684 (1992).
CAS PubMed Google Scholar
- Levin, J. et al. Thrombocytopenic c-mpl−/− mice can produce a normal level of platelets after administration of 5-fluorouracil: the effect of age on the response. Blood 98, 1019–1027 (2001).
Article CAS PubMed Google Scholar
- Petit, I. et al. G-CSF induces stem cell mobilization by decreasing bone marrow SDF-1 and up-regulating CXCR4. Nat. Immunol. 3, 687–694 (2002).
Article CAS PubMed Google Scholar
- Peled, A. et al. Dependence of human stem cell engraftment and repopulation of NOD/SCID mice on CXCR4. Science 283, 845–851 (1999).
Article CAS PubMed Google Scholar
- Kuter, D.J. & Begley, C.G. Recombinant human thrombopoietin: basic biology and evaluation of clinical studies. Blood 100, 3457–3469 (2002).
Article CAS PubMed Google Scholar
- Kuter, D.J. Whatever happened to thrombopoietin? Transfusion 42, 279–283 (2002).
Article PubMed Google Scholar
- Vadhan-Raj, S. et al. Recombinant human thrombopoietin attenuates carboplatin-induced severe thrombocytopenia and the need for platelet transfusions in patients with gynecologic cancer. Ann. Intern. Med. 132, 364–368 (2000).
Article CAS PubMed Google Scholar
- Mossuz, P., Schweitzer, A., Molla, A. & Berthier, R. Expression and function of receptors for extracellular matrix molecules in the differentiation of human megakaryocytes in vitro. Br. J. Haematol. 98, 819–827 (1997).
Article CAS PubMed Google Scholar
- Hodohara, K., Fujii, N., Yamamoto, N. & Kaushansky, K. Stromal cell-derived factor-1 (SDF-1) acts together with thrombopoietin to enhance the development of megakaryocytic progenitor cells (CFU-MK). Blood 95, 769–775 (2000).
CAS PubMed Google Scholar
- Delehanty, L.L. et al. Stromal inhibition of megakaryocytic differentiation is associated with blockade of sustained Rap1 activation. Blood 101, 1744–1751 (2003).
Article CAS PubMed Google Scholar
- Zweegman, S., Veenhof, M.A., Huijgens, P.C., Schuurhuis, G.J. & Drager, A.M. Regulation of megakaryocytopoiesis in an in vitro stroma model: preferential adhesion of megakaryocytic progenitors and subsequent inhibition of maturation. Exp. Hematol. 28, 401–410 (2000).
Article CAS PubMed Google Scholar
- Rafii, S., Mohle, R., Shapiro, F., Frey, B.M. & Moore, M.A. Regulation of hematopoiesis by microvascular endothelium. Leuk. Lymphoma 27, 375–386 (1997).
Article CAS PubMed Google Scholar
- Almeida-Porada, G. & Ascensao, J.L. Isolation, characterization, and biologic features of bone marrow endothelial cells. J. Lab. Clin. Med. 128, 399–407 (1996).
Article CAS PubMed Google Scholar
- Schweitzer, K.M. et al. Constitutive expression of E-selectin and vascular cell adhesion molecule-1 on endothelial cells of hematopoietic tissues. Am. J. Pathol. 148, 165–175 (1996).
CAS PubMed PubMed Central Google Scholar
- Masek, L.C., Sweetenham, J.W., Whitehouse, J.M. & Schumacher, U. Immuno-, lectin-, and enzyme-histochemical characterization of human bone marrow endothelium. Exp. Hematol. 22, 1203–1239 (1994).
CAS PubMed Google Scholar
- Mohle, R., Green, D., Moore, M.A., Nachman, R.L. & Rafii, S. Constitutive production and thrombin-induced release of vascular endothelial growth factor by human megakaryocytes and platelets. Proc. Natl. Acad. Sci. USA 94, 663–668 (1997).
Article CAS PubMed PubMed Central Google Scholar
- Vadhan-Raj, S. et al. Importance of predosing of recombinant human thrombopoietin to reduce chemotherapy-induced early thrombocytopenia. J. Clin. Oncol. 21, 3158–3167 (2003).
Article CAS PubMed Google Scholar
- Schabath, R. et al. The murine chemokine receptor CXCR4 is tightly regulated during T cell development and activation. J. Leukoc. Biol. 66, 996–1004 (1999).
Article CAS PubMed Google Scholar
- Forster, R. et al. Intracellular and surface expression of the HIV-1 coreceptor CXCR4/fusin on various leukocyte subsets: rapid internalization and recycling upon activation. J. Immunol. 160, 1522–1531 (1998).
CAS PubMed Google Scholar