Role of teichoic acids in Staphylococcus aureus nasal colonization, a major risk factor in nosocomial infections (original) (raw)
- Brief Communication
- Published: 01 February 2004
- John F Kokai-Kun2,
- Sascha A Kristian3,4,
- Tanya Chanturiya2,
- Hubert Kalbacher5,
- Matthias Gross4,
- Graeme Nicholson6,
- Birgid Neumeister3,
- James J Mond2 &
- …
- Andreas Peschel1
Nature Medicine volume 10, pages 243–245 (2004)Cite this article
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Abstract
Colonization of the anterior nares in ∼37% of the population is a major risk factor for severe Staphylococcus aureus infections. Here we show that wall teichoic acid (WTA), a surface-exposed staphylococcal polymer, is essential for nasal colonization and mediates interaction with human nasal epithelial cells. WTA-deficient mutants were impaired in their adherence to nasal cells, and were completely unable to colonize cotton rat nares. This study describes the first essential factor for S. aureus nasal colonization.
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Figure 1: WTA mediates interaction with nasal epithelial cells.
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Acknowledgements
We thank F. Götz, G.W. Fischer and I.B. Autenrieth for support and helpful discussions; V. Augsburger, R. Oueslati and J. Schnaut for technical assistance; and S.E. Cramton and W. Vollmer for critically reading the manuscript. This work was supported by grants from the German Research Council (SPP1047 and FOR 449/T2) and from Biosynexus to A.P.
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Authors and Affiliations
- Medical Microbiology and Hygiene Department, Cellular and Molecular Microbiology, University of Tübingen, Elfriede-Aulhorn-Strasse 6, Tübingen, 72076, Germany
Christopher Weidenmaier & Andreas Peschel - Biosynexus Inc., 9119 Gaither Rd., Gaithersburg, 20877, Maryland, USA
John F Kokai-Kun, Tanya Chanturiya & James J Mond - Department of Transfusion Medicine, University of Tübingen, Otfried-Müller-Strasse 4/1, Tübingen, 72076, Germany
Sascha A Kristian & Birgid Neumeister - Microbial Genetics, University of Tübingen, Waldhäuser Strasse 70/8, Tübingen, 72076, Germany
Sascha A Kristian & Matthias Gross - Medical and Natural Sciences Research Center, University of Tübingen, Ob dem Himmelreich 7, Tübingen, 72074, Germany
Hubert Kalbacher - Organic Chemistry Department, University of Tübingen, Auf der Morgenstelle 18, Tübingen, 72076, Germany
Graeme Nicholson
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Weidenmaier, C., Kokai-Kun, J., Kristian, S. et al. Role of teichoic acids in Staphylococcus aureus nasal colonization, a major risk factor in nosocomial infections.Nat Med 10, 243–245 (2004). https://doi.org/10.1038/nm991
- Received: 16 November 2003
- Accepted: 05 January 2004
- Published: 01 February 2004
- Issue Date: 01 March 2004
- DOI: https://doi.org/10.1038/nm991