Comparative analysis to guide quality improvements in proteomics (original) (raw)
- Commentary
- Published: October 2009
Nature Methods volume 6, pages 717–719 (2009)Cite this article
- 2689 Accesses
- 60 Citations
- Metrics details
The potential of mass spectrometry–based proteomics to advance biology and biomedicine is nearly unlimited but so is its potential for generating bad data. Apart from the pursuit of technological progress in protocols and instruments, stringent comparative analyses of different approaches are critical for fully developing the discipline.
This is a preview of subscription content, access via your institution
Relevant articles
Open Access articles citing this article.
The role of quantitative mass spectrometry in the discovery of pancreatic cancer biomarkers for translational science
- Daniel Ansari
- , Linus Aronsson
- … Roland Andersson
Journal of Translational Medicine Open Access 05 April 2014
Computational mass spectrometry for small molecules
- Kerstin Scheubert
- , Franziska Hufsky
- & Sebastian Böcker
Journal of Cheminformatics Open Access 01 March 2013
Current challenges in software solutions for mass spectrometry-based quantitative proteomics
- Salvatore Cappadona
- , Peter R. Baker
- … Bas van Breukelen
Amino Acids Open Access 22 July 2012
Access options
Subscribe to this journal
Receive 12 print issues and online access
$259.00 per year
only $21.58 per issue
Buy this article
- Purchase on SpringerLink
- Instant access to the full article PDF.
USD 39.95
Prices may be subject to local taxes which are calculated during checkout
Additional access options:
Figure 1

iStockphoto
Figure 2

References
- Mann, M. & Kelleher, N.L. Proc. Natl. Acad. Sci. USA 105, 18132–18138 (2008).
Article CAS Google Scholar - Olsen, J.V., Ong, S.E. & Mann, M. Mol. Cell. Proteomics 3, 608–614 (2004).
Article CAS Google Scholar - Keller, A., Nesvizhskii, A.I., Kolker, E. & Aebersold, R. Anal. Chem. 74, 5383–5392 (2002).
Article CAS Google Scholar - Nesvizhskii, A.I., Keller, A., Kolker, E. & Aebersold, R. Anal. Chem. 75, 4646–4658 (2003).
Article CAS Google Scholar - Elias, J.E. & Gygi, S.P. Nat. Methods 4, 207–217 (2007).
Article CAS Google Scholar - Kim, S., Gupta, N. & Pevzner, P.A. J. Proteome Res. 7, 3354–3363 (2008).
Article CAS Google Scholar - Elias, J.E., Haas, W., Faherty, B.K. & Gygi, S.P. Nat. Methods 2, 667–675 (2005).
Article CAS Google Scholar - Perkins, D.N. Pappin, D.J.C., Creasy, D.M. & Cottrell, J.S. Electrophoresis 20, 3551–3567 (1999).
Article CAS Google Scholar - Eng, J.K., McCormack, A.L. & Yates, J.R. III J. Am. Soc. Mass Spectrom. 5, 976–989 (1994).
Article CAS Google Scholar - Cox, J. & Mann, M. Nat. Biotechnol. 26, 1367–1372 (2008).
Article CAS Google Scholar - Bodenmiller, B. Mueller, L.N., Mueller, M., Domon, B. & Aebersold, R. Nat. Methods 4, 231–237 (2007).
Article CAS Google Scholar - Olsen, J.V. et al. Cell 127, 635–648 (2006).
Article CAS Google Scholar - Bodenmiller, B. et al. Mol. Syst. Biol. 3, 139 (2007).
Article Google Scholar - Hilger, M. Bonaldi, T., Gnad, F. & Mann, M. Mol. Cell Proteomics 8, 1908–1920 (2009).
Article CAS Google Scholar - Bonaldi, T. et al. Mol. Cell 31, 762–772 (2008).
Article CAS Google Scholar - Bell, A.W. et al. Nat. Methods 6, 423–430 (2009).
Article CAS Google Scholar - de Godoy, L.M. et al. Nature 455, 1251–1254 (2008).
Article CAS Google Scholar - Addona, T.A. et al. Nat. Biotechnol. 27, 633–641 (2009).
Article CAS Google Scholar - Kumar, C. & Mann, M. FEBS Lett. 583, 1703–1712 (2009).
Article CAS Google Scholar
Author information
Authors and Affiliations
- Matthias Mann is at the Max Planck Institute for Biochemistry, Matrinsried, Germany. mmann@biochem.mpg.de,
Matthias Mann
Rights and permissions
About this article
Cite this article
Mann, M. Comparative analysis to guide quality improvements in proteomics.Nat Methods 6, 717–719 (2009). https://doi.org/10.1038/nmeth1009-717
- Issue date: October 2009
- DOI: https://doi.org/10.1038/nmeth1009-717