Excess protein synthesis in Drosophila Fragile X mutants impairs long-term memory (original) (raw)

Nature Neuroscience volume 11, pages 1143–1145 (2008)Cite this article

Abstract

We used Drosophila olfactory memory as a model to study the molecular basis of cognitive defects in Fragile X syndrome in vivo. We observed that fragile X protein was acutely required and interacted with argonaute1 and staufen in the formation of long-term memory. Occlusion of long-term memory formation in Fragile X mutants could be rescued by protein synthesis inhibitors, suggesting that excess baseline protein synthesis could negatively affect cognition.

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Acknowledgements

F.V.B. conceptualized the project, conducted experiments and wrote the manuscript. K.B. carried out behavioral experiments, H.C. performed the imaging experiments and K.S.B. helped with conceptualization. T.T. conceptualized, supervised and funded the project and wrote the manuscript.

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Author notes

  1. François V Bolduc
    Present address: Present address: Division of Pediatric Neuroscience, University of Alberta, Alberta T6G2J3, Canada.,

Authors and Affiliations

  1. Watson School of Biological Sciences, 1 Bungtown Road, Cold Spring Harbor, 11724, New York, USA
    François V Bolduc & Tim Tully
  2. Cold Spring Harbor Laboratory, 1 Bungtown Road, Cold Spring Harbor, 11724, New York, USA
    François V Bolduc, Kimberly Bell, Hilary Cox & Tim Tully
  3. Vanderbilt University 1210 MRB III, VU Station B, Box 35-1634, Nashville, 37235-1634, Tennessee, USA
    Kendal S Broadie
  4. Dart Neuroscience, LLC, 7374 Lusk Blvd., San Diego, 92121, California, USA
    Tim Tully

Authors

  1. François V Bolduc
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  2. Kimberly Bell
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  3. Hilary Cox
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  4. Kendal S Broadie
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  5. Tim Tully
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Correspondence toTim Tully.

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Bolduc, F., Bell, K., Cox, H. et al. Excess protein synthesis in Drosophila Fragile X mutants impairs long-term memory.Nat Neurosci 11, 1143–1145 (2008). https://doi.org/10.1038/nn.2175

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