Palmitoylation-dependent neurodevelopmental deficits in a mouse model of 22q11 microdeletion (original) (raw)
McDonald-McGinn, D.M. et al. Phenotype of the 22q11.2 deletion in individuals identified through an affected relative: cast a wide FISHing net!. Genet. Med.3, 23–29 (2001). ArticleCASPubMed Google Scholar
Woodin, M. et al. Neuropsychological profile of children and adolescents with the 22q11.2 microdeletion. Genet. Med.3, 34–39 (2001). ArticleCASPubMed Google Scholar
Bearden, C.E. et al. The neurocognitive phenotype of the 22q11.2 deletion syndrome: selective deficit in visual-spatial memory. J. Clin. Exp. Neuropsychol.23, 447–464 (2001). ArticleCASPubMed Google Scholar
Sobin, C. et al. Neuropsychological characteristics of children with the 22q11 Deletion Syndrome: a descriptive analysis. Child Neuropsychol.11, 39–53 (2005). ArticlePubMedPubMed Central Google Scholar
Chow, E.W., Watson, M., Young, D.A. & Bassett, A.S. Neurocognitive profile in 22q11 deletion syndrome and schizophrenia. Schizophr. Res.87, 270–278 (2006). ArticlePubMedPubMed Central Google Scholar
Pulver, A.E. et al. Psychotic illness in patients diagnosed with velo-cardio-facial syndrome and their relatives. J. Nerv. Ment. Dis.182, 476–478 (1994). ArticleCASPubMed Google Scholar
Karayiorgou, M. et al. Schizophrenia susceptibility associated with interstitial deletions of chromosome 22q11. Proc. Natl. Acad. Sci. USA92, 7612–7616 (1995). ArticleCASPubMedPubMed Central Google Scholar
Xu, B. et al. Strong association of de novo copy number mutations with sporadic schizophrenia. Nat. Genet.40, 880–885 (2008). ArticleCASPubMed Google Scholar
Edelmann, L., Pandita, R.K. & Morrow, B.E. Low-copy repeats mediate the common 3-Mb deletion in patients with velo-cardio-facial syndrome. Am. J. Hum. Genet.64, 1076–1086 (1999). ArticleCASPubMedPubMed Central Google Scholar
Gothelf, D. et al. COMT genotype predicts longitudinal cognitive decline and psychosis in 22q11.2 deletion syndrome. Nat. Neurosci.8, 1500–1502 (2005). ArticleCASPubMed Google Scholar
Mukai, J. et al. Evidence that the gene encoding ZDHHC8 contributes to the risk of schizophrenia. Nat. Genet.36, 725–731 (2004). ArticleCASPubMed Google Scholar
Paterlini, M. et al. Transcriptional and behavioral interaction between 22q11.2 orthologs modulates schizophrenia-related phenotypes in mice. Nat. Neurosci.8, 1586–1594 (2005). ArticleCASPubMed Google Scholar
Raux, G. et al. Involvement of hyperprolinemia in cognitive and psychiatric features of the 22q11 deletion syndrome. Hum. Mol. Genet.16, 83–91 (2007). ArticleCASPubMed Google Scholar
Fukata, M., Fukata, Y., Adesnik, H., Nicoll, R.A. & Bredt, D.S. Identification of PSD95 palmitoylating enzymes. Neuron44, 987–996 (2004). ArticleCASPubMed Google Scholar
Linder, M.E. & Deschenes, R.J. Model organisms lead the way to protein palmitoyltransferases. J. Cell Sci.117, 521–526 (2004). ArticleCASPubMed Google Scholar
Roth, A.F., Feng, Y., Chen, L. & Davis, N.G. The yeast DHHC cysteine-rich domain protein Akr1p is a palmitoyl transferase. J. Cell Biol.159, 23–28 (2002). ArticleCASPubMedPubMed Central Google Scholar
Smotrys, J.E. & Linder, M.E. Palmitoylation of intracellular signaling proteins: regulation and function. Annu. Rev. Biochem.73, 559–587 (2004). ArticleCASPubMed Google Scholar
Bijlmakers, M.J. & Marsh, M. The on-off story of protein palmitoylation. Trends Cell Biol.13, 32–42 (2003). ArticleCASPubMed Google Scholar
el-Husseini, A.E. & Bredt, D.S. Protein palmitoylation: a regulator of neuronal development and function. Nat. Rev. Neurosci.3, 791–802 (2002). ArticleCAS Google Scholar
Chen, W.Y. et al. Case-control study and transmission disequilibrium test provide consistent evidence for association between schizophrenia and genetic variation in the 22q11 gene ZDHHC8. Hum. Mol. Genet.13, 2991–2995 (2004). ArticleCASPubMed Google Scholar
Glaser, B. et al. No association between the putative functional ZDHHC8 single nucleotide polymorphism rs175174 and schizophrenia in large European samples. Biol. Psychiatry58, 78–80 (2005). ArticleCASPubMed Google Scholar
Puech, A. et al. Comparative mapping of the human 22q11 chromosomal region and the orthologous region in mice reveals complex changes in gene organization. Proc. Natl. Acad. Sci. USA94, 14608–14613 (1997). ArticleCASPubMedPubMed Central Google Scholar
Stark, K.L. et al. Altered brain microRNA biogenesis contributes to phenotypic deficits in a 22q11-deletion mouse model. Nat. Genet.40, 751–760 (2008). ArticleCASPubMed Google Scholar
El-Husseini, A.E., Schnell, E., Chetkovich, D.M., Nicoll, R.A. & Bredt, D.S. PSD95 involvement in maturation of excitatory synapses. Science290, 1364–1368 (2000). CASPubMed Google Scholar
Sala, C. et al. Regulation of dendritic spine morphology and synaptic function by Shank and Homer. Neuron31, 115–130 (2001). ArticleCASPubMed Google Scholar
Charych, E.I. et al. Activity-independent regulation of dendrite patterning by postsynaptic density protein PSD95. J. Neurosci.26, 10164–10176 (2006). ArticleCASPubMedPubMed Central Google Scholar
Chakravarthy, S. et al. Postsynaptic TrkB signaling has distinct roles in spine maintenance in adult visual cortex and hippocampus. Proc. Natl. Acad. Sci. USA103, 1071–1076 (2006). ArticleCASPubMedPubMed Central Google Scholar
Bekkers, J.M. & Stevens, C.F. Excitatory and inhibitory autaptic currents in isolated hippocampal neurons maintained in cell culture. Proc. Natl. Acad. Sci. USA88, 7834–7838 (1991). ArticleCASPubMedPubMed Central Google Scholar
Cho, K.O., Hunt, C.A. & Kennedy, M.B. The rat brain postsynaptic density fraction contains a homolog of the Drosophila discs-large tumor suppressor protein. Neuron9, 929–942 (1992). ArticleCASPubMed Google Scholar
Kornau, H.C., Schenker, L.T., Kennedy, M.B. & Seeburg, P.H. Domain interaction between NMDA receptor subunits and the postsynaptic density protein PSD95. Science269, 1737–1740 (1995). ArticleCASPubMed Google Scholar
Bellocchio, E.E., Reimer, R.J., Fremeau, R.T. Jr. & Edwards, R.H. Uptake of glutamate into synaptic vesicles by an inorganic phosphate transporter. Science289, 957–960 (2000). ArticleCASPubMed Google Scholar
Ohno, Y., Kihara, A., Sano, T. & Igarashi, Y. Intracellular localization and tissue-specific distribution of human and yeast DHHC cysteine-rich domain-containing proteins. Biochim. Biophys. Acta1761, 474–483 (2006). ArticleCASPubMed Google Scholar
Gauthier-Campbell, C., Bredt, D.S., Murphy, T.H. & El-Husseini Ael, D. Regulation of dendritic branching and filopodia formation in hippocampal neurons by specific acylated protein motifs. Mol. Biol. Cell15, 2205–2217 (2004). ArticleCASPubMedPubMed Central Google Scholar
Feng, G. et al. Imaging neuronal subsets in transgenic mice expressing multiple spectral variants of GFP. Neuron28, 41–51 (2000). ArticleCASPubMed Google Scholar
Tada, T. & Sheng, M. Molecular mechanisms of dendritic spine morphogenesis. Curr. Opin. Neurobiol.16, 95–101 (2006). ArticleCASPubMed Google Scholar
Vessey, J.P. & Karra, D. More than just synaptic building blocks: scaffolding proteins of the post-synaptic density regulate dendritic patterning. J. Neurochem.102, 324–332 (2007). ArticleCASPubMed Google Scholar
el-Husseini, A.E. et al. Synaptic strength regulated by palmitate cycling on PSD95. Cell108, 849–863 (2002). ArticleCAS Google Scholar
Topinka, J.R. & Bredt, D.S. N-terminal palmitoylation of PSD95 regulates association with cell membranes and interaction with K+ channel Kv1.4. Neuron20, 125–134 (1998). ArticleCASPubMed Google Scholar
Ehrlich, I., Klein, M., Rumpel, S. & Malinow, R. PSD95 is required for activity-driven synapse stabilization. Proc. Natl. Acad. Sci. USA104, 4176–4181 (2007). ArticleCASPubMedPubMed Central Google Scholar
Firestein, B.L., Craven, S.E. & Bredt, D.S. Postsynaptic targeting of MAGUKs mediated by distinct N-terminal domains. Neuroreport11, 3479–3484 (2000). ArticleCASPubMed Google Scholar
Kanaani, J., Diacovo, M.J., El-Husseini Ael, D., Bredt, D.S. & Baekkeskov, S. Palmitoylation controls trafficking of GAD65 from Golgi membranes to axon-specific endosomes and a Rab5a-dependent pathway to presynaptic clusters. J. Cell Sci.117, 2001–2013 (2004). ArticleCASPubMed Google Scholar
Kang, R. et al. Presynaptic trafficking of synaptotagmin I is regulated by protein palmitoylation. J. Biol. Chem.279, 50524–50536 (2004). ArticleCASPubMed Google Scholar
Washbourne, P. et al. Cysteine residues of SNAP-25 are required for SNARE disassembly and exocytosis, but not for membrane targeting. Biochem. J.357, 625–634 (2001). ArticleCASPubMedPubMed Central Google Scholar
Berthiaume, L. & Resh, M.D. Biochemical characterization of a palmitoyl acyltransferase activity that palmitoylates myristoylated proteins. J. Biol. Chem.270, 22399–22405 (1995). ArticleCASPubMed Google Scholar
El-Husseini, A.E. et al. Dual palmitoylation of PSD95 mediates its vesiculotubular sorting, postsynaptic targeting, and ion channel clustering. J. Cell Biol.148, 159–172 (2000). ArticleCASPubMedPubMed Central Google Scholar
Karayiorgou, M. & Gogos, J.A. The molecular genetics of the 22q11-associated schizophrenia. Brain Res. Mol. Brain Res.132, 95–104 (2004). ArticleCASPubMed Google Scholar
Valdez-Taubas, J. & Pelham, H. Swf1-dependent palmitoylation of the SNARE Tlg1 prevents its ubiquitination and degradation. EMBO J.24, 2524–2532 (2005). ArticleCASPubMedPubMed Central Google Scholar
Huang, K. et al. Huntingtin-interacting protein HIP14 is a palmitoyl transferase involved in palmitoylation and trafficking of multiple neuronal proteins. Neuron44, 977–986 (2004). ArticleCASPubMed Google Scholar
Arguello, P.A. & Gogos, J.A. Modeling madness in mice: one piece at a time. Neuron52, 179–196 (2006). ArticleCASPubMed Google Scholar
Gu, J.G. & MacDermott, A.B. Activation of ATP P2X receptors elicits glutamate release from sensory neuron synapses. Nature389, 749–753 (1997). ArticleCASPubMed Google Scholar