Amyloid beta from axons and dendrites reduces local spine number and plasticity (original) (raw)
Terry, R.D. et al. Physical basis of cognitive alterations in Alzheimer's disease: synapse loss is the major correlate of cognitive impairment. Ann. Neurol.30, 572–580 (1991). ArticleCAS Google Scholar
Walsh, D.M. & Selkoe, D.J. Deciphering the molecular basis of memory failure in Alzheimer's disease. Neuron44, 181–193 (2004). ArticleCAS Google Scholar
Lacor, P.N. et al. Synaptic targeting by Alzheimer's-related amyloid beta oligomers. J. Neurosci.24, 10191–10200 (2004). ArticleCAS Google Scholar
Hsieh, H. et al. AMPAR removal underlies Abeta-induced synaptic depression and dendritic spine loss. Neuron52, 831–843 (2006). ArticleCAS Google Scholar
Shankar, G.M. et al. Natural oligomers of the Alzheimer amyloid-beta protein induce reversible synapse loss by modulating an NMDA-type glutamate receptor-dependent signaling pathway. J. Neurosci.27, 2866–2875 (2007). ArticleCAS Google Scholar
Shrestha, B.R. et al. Amyloid beta peptide adversely affects spine number and motility in hippocampal neurons. Mol. Cell. Neurosci.33, 274–282 (2006). ArticleCAS Google Scholar
Calabrese, B. et al. Rapid, concurrent alterations in pre- and postsynaptic structure induced by naturally-secreted amyloid-beta protein. Mol. Cell. Neurosci.35, 183–193 (2007). ArticleCAS Google Scholar
Evans, N.A. et al. Abeta(1–42) reduces synapse number and inhibits neurite outgrowth in primary cortical and hippocampal neurons: a quantitative analysis. J. Neurosci. Methods175, 96–103 (2008). ArticleCAS Google Scholar
Lacor, P.N. et al. Abeta oligomer-induced aberrations in synapse composition, shape, and density provide a molecular basis for loss of connectivity in Alzheimer's disease. J. Neurosci.27, 796–807 (2007). ArticleCAS Google Scholar
Lanz, T.A., Carter, D.B. & Merchant, K.M. Dendritic spine loss in the hippocampus of young PDAPP and Tg2576 mice and its prevention by the ApoE2 genotype. Neurobiol. Dis.13, 246–253 (2003). ArticleCAS Google Scholar
Jacobsen, J.S. et al. Early-onset behavioral and synaptic deficits in a mouse model of Alzheimer's disease. Proc. Natl. Acad. Sci. USA103, 5161–5166 (2006). ArticleCAS Google Scholar
Spires, T.L. et al. Dendritic spine abnormalities in amyloid precursor protein transgenic mice demonstrated by gene transfer and intravital multiphoton microscopy. J. Neurosci.25, 7278–7287 (2005). ArticleCAS Google Scholar
Kamenetz, F. et al. APP processing and synaptic function. Neuron37, 925–937 (2003). ArticleCAS Google Scholar
Snyder, E.M. et al. Regulation of NMDA receptor trafficking by amyloid-beta. Nat. Neurosci.8, 1051–1058 (2005). ArticleCAS Google Scholar
Almeida, C.G. et al. Beta-amyloid accumulation in APP mutant neurons reduces PSD-95 and GluR1 in synapses. Neurobiol. Dis.20, 187–198 (2005). ArticleCAS Google Scholar
Ting, J.T., Kelley, B.G., Lambert, T.J., Cook, D.G. & Sullivan, J.M. Amyloid precursor protein overexpression depresses excitatory transmission through both presynaptic and postsynaptic mechanisms. Proc. Natl. Acad. Sci. USA104, 353–358 (2007). ArticleCAS Google Scholar
Walsh, D.M. et al. Naturally secreted oligomers of amyloid beta protein potently inhibit hippocampal long-term potentiation in vivo. Nature416, 535–539 (2002). ArticleCAS Google Scholar
Chapman, P.F. et al. Impaired synaptic plasticity and learning in aged amyloid precursor protein transgenic mice. Nat. Neurosci.2, 271–276 (1999). ArticleCAS Google Scholar
Stéphan, A., Laroche, S. & Davis, S. Generation of aggregated beta-amyloid in the rat hippocampus impairs synaptic transmission and plasticity and causes memory deficits. J. Neurosci.21, 5703–5714 (2001). Article Google Scholar
Cleary, J.P. et al. Natural oligomers of the amyloid-beta protein specifically disrupt cognitive function. Nat. Neurosci.8, 79–84 (2005). ArticleCAS Google Scholar
Klyubin, I. et al. Amyloid beta protein immunotherapy neutralizes Abeta oligomers that disrupt synaptic plasticity in vivo. Nat. Med.11, 556–561 (2005). ArticleCAS Google Scholar
Hartman, R.E. et al. Treatment with an amyloid-beta antibody ameliorates plaque load, learning deficits and hippocampal long-term potentiation in a mouse model of Alzheimer's disease. J. Neurosci.25, 6213–6220 (2005). ArticleCAS Google Scholar
Walsh, D.M. et al. Certain inhibitors of synthetic amyloid beta-peptide (Abeta) fibrillogenesis block oligomerization of natural Abeta and thereby rescue long-term potentiation. J. Neurosci.25, 2455–2462 (2005). ArticleCAS Google Scholar
Morgan, D. et al. A beta peptide vaccination prevents memory loss in an animal model of Alzheimer's disease. Nature408, 982–985 (2000). ArticleCAS Google Scholar
Kopec, C.D., Li, B., Wei, W., Boehm, J. & Malinow, R. Glutamate receptor exocytosis and spine enlargement during chemically induced long-term potentiation. J. Neurosci.26, 2000–2009 (2006). ArticleCAS Google Scholar
Engert, F. & Bonhoeffer, T. Dendritic spine changes associated with hippocampal long-term synaptic plasticity. Nature399, 66–70 (1999). ArticleCAS Google Scholar
Maletic-Savatic, M., Malinow, R. & Svoboda, K. Rapid dendritic morphogenesis in CA1 hippocampal dendrites induced by synaptic activity. Science283, 1923–1927 (1999). ArticleCAS Google Scholar
Matsuzaki, M., Honkura, N., Ellis-Davies, G.C. & Kasai, H. Structural basis of long-term potentiation in single dendritic spines. Nature429, 761–766 (2004). ArticleCAS Google Scholar
Cirrito, J.R. et al. Synaptic activity regulates interstitial fluid amyloid-beta levels in vivo. Neuron48, 913–922 (2005). ArticleCAS Google Scholar
Buckner, R.L. et al. Molecular, structural, and functional characterization of Alzheimer's disease: evidence for a relationship between default activity, amyloid, and memory. J. Neurosci.25, 7709–7717 (2005). ArticleCAS Google Scholar
Lazarov, O., Lee, M., Peterson, D.A. & Sisodia, S.S. Evidence that synaptically released beta-amyloid accumulates as extracellular deposits in the hippocampus of transgenic mice. J. Neurosci.22, 9785–9793 (2002). ArticleCAS Google Scholar
Buxbaum, J.D. et al. Alzheimer amyloid protein precursor in the rat hippocampus: transport and processing through the perforant path. J. Neurosci.18, 9629–9637 (1998). ArticleCAS Google Scholar
Koo, E.H. et al. Precursor of amyloid protein in Alzheimer disease undergoes fast anterograde axonal transport. Proc. Natl. Acad. Sci. USA87, 1561–1565 (1990). ArticleCAS Google Scholar
Ferreira, A., Caceres, A. & Kosik, K.S. Intraneuronal compartments of the amyloid precursor protein. J. Neurosci.13, 3112–3123 (1993). ArticleCAS Google Scholar
Sisodia, S.S., Koo, E.H., Hoffman, P.N., Perry, G. & Price, D.L. Identification and transport of full-length amyloid precursor proteins in rat peripheral nervous system. J. Neurosci.13, 3136–3142 (1993). ArticleCAS Google Scholar
Xia, W. et al. A specific enzyme-linked immunosorbent assay for measuring beta-amyloid protein oligomers in human plasma and brain tissue of patients with Alzheimer disease. Arch. Neurol.66, 190–199 (2009). Article Google Scholar
Kaether, C., Skehel, P. & Dotti, C.G. Axonal membrane proteins are transported in distinct carriers: a two-color video microscopy study in cultured hippocampal neurons. Mol. Biol. Cell11, 1213–1224 (2000). ArticleCAS Google Scholar
Shankar, G.M. et al. Amyloid-beta protein dimers isolated directly from Alzheimer's brains impair synaptic plasticity and memory. Nat. Med.14, 837–842 (2008). ArticleCAS Google Scholar
Otmakhov, N. et al. Forskolin-induced LTP in the CA1 hippocampal region is NMDA receptor dependent. J. Neurophysiol.91, 1955–1962 (2004). ArticleCAS Google Scholar
Changeux, J.P., Kasai, M. & Lee, C.Y. Use of a snake venom toxin to characterize the cholinergic receptor protein. Proc. Natl. Acad. Sci. USA67, 1241–1247 (1970). ArticleCAS Google Scholar
Small, S.A. & Gandy, S. Sorting through the cell biology of Alzheimer's disease: intracellular pathways to pathogenesis. Neuron52, 15–31 (2006). ArticleCAS Google Scholar
Sheng, J.G., Price, D.L. & Koliatsos, V.E. Disruption of corticocortical connections ameliorates amyloid burden in terminal fields in a transgenic model of Abeta amyloidosis. J. Neurosci.22, 9794–9799 (2002). ArticleCAS Google Scholar
Klyubin, I. et al. Amyloid beta protein dimer-containing human CSF disrupts synaptic plasticity: prevention by systemic passive immunization. J. Neurosci.28, 4231–4237 (2008). ArticleCAS Google Scholar
Jones, I.W., Barik, J., O'Neill, M.J. & Wonnacott, S. Alpha bungarotoxin-1.4 nm gold: a novel conjugate for visualising the precise subcellular distribution of alpha 7* nicotinic acetylcholine receptors. J. Neurosci. Methods134, 65–74 (2004). ArticleCAS Google Scholar
Fabian-Fine, R. et al. Ultrastructural distribution of the alpha7 nicotinic acetylcholine receptor subunit in rat hippocampus. J. Neurosci.21, 7993–8003 (2001). ArticleCAS Google Scholar
Dineley, K.T., Bell, K.A., Bui, D. & Sweatt, J.D. Beta-amyloid peptide activates alpha 7 nicotinic acetylcholine receptors expressed in Xenopus oocytes. J. Biol. Chem.277, 25056–25061 (2002). ArticleCAS Google Scholar
Dani, J.A. & Bertrand, D. Nicotinic acetylcholine receptors and nicotinic cholinergic mechanisms of the central nervous system. Annu. Rev. Pharmacol. Toxicol.47, 699–729 (2007). ArticleCAS Google Scholar
Raschetti, R., Albanese, E., Vanacore, N. & Maggini, M. Cholinesterase inhibitors in mild cognitive impairment: a systematic review of randomized trials. PLoS Med.4, e338 (2007). Article Google Scholar
Coan, E.J., Irving, A.J. & Collingridge, G.L. Low-frequency activation of the NMDA receptor system can prevent the induction of LTP. Neurosci. Lett.105, 205–210 (1989). ArticleCAS Google Scholar
Molnár, Z. et al. Enhancement of NMDA responses by beta-amyloid peptides in the hippocampus in vivo. Neuroreport15, 1649–1652 (2004). Article Google Scholar