Bimodal control of stimulated food intake by the endocannabinoid system (original) (raw)

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Acknowledgements

We thank F. George, P. Ciofi, V. Deroche-Gamonet and O. Moustie for help, D. Gonzales and the Genotyping Platform of the NeuroCentre Magendie for mouse genotyping, S.K. Nave, J. Rubenstein, M. Ekker, G. Schütz, T. Lemberger for providing Cre-expressing mice, and C.T. Wotjak, U. Pagotto, K. Monory, J. Lourenço, M. Vallée, B. Lutz and all the members of the Marsicano laboratory for valuable suggestions. This work was supported by AVENIR/INSERM and Fondation Bettencourt-Schueller (G.M.), Agence National de la Recherche (ANR-06-NEURO-043-01 to G.M.), the European Foundation for the Study of Diabetes (G.M.), European Union Seventh Framework Program (REPROBESITY, HEALTH-F2-2008-223713 to G.M.), European Commission Network of European Neuroscience Institutes (ENINET) (LSHM-CT-2005-19063 to G.M.), the Basque Country Government (GIC07/70-IT-432-07 to P.G.), Red de Trastornos Adictivos, Instituto de Salud Carlos III, Ministerio de Ciencia e Innovación, Gobierno de España (RD07/0001/2001 to P.G.) and Basque Country University (N.P.).

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Author notes

  1. Luigi Bellocchio, Pauline Lafenêtre, Pier Vincenzo Piazza and Giovanni Marsicano: These authors contributed equally to this work.

Authors and Affiliations

  1. INSERM U862, NeuroCentre Magendie, Endocannabinoids and Neuroadaptation, Bordeaux, France
    Luigi Bellocchio, Pauline Lafenêtre, Astrid Cannich, Francis Chaouloff & Giovanni Marsicano
  2. University of Bordeaux, Bordeaux, France
    Luigi Bellocchio, Pauline Lafenêtre, Astrid Cannich, Daniela Cota, Francis Chaouloff, Pier Vincenzo Piazza & Giovanni Marsicano
  3. INSERM U862, NeuroCentre Magendie, Energy Balance and Obesity, Bordeaux, France
    Daniela Cota
  4. Department of Neurosciences, Faculty of Medicine and Dentistry, Basque Country University, Leioia, Spain
    Nagore Puente & Pedro Grandes
  5. INSERM U862, NeuroCentre Magendie, Physiopathology of Addiction, Bordeaux, France
    Pier Vincenzo Piazza

Authors

  1. Luigi Bellocchio
  2. Pauline Lafenêtre
  3. Astrid Cannich
  4. Daniela Cota
  5. Nagore Puente
  6. Pedro Grandes
  7. Francis Chaouloff
  8. Pier Vincenzo Piazza
  9. Giovanni Marsicano

Contributions

L.B. designed and performed experiments. P.L. carried out part of the food-intake experiments. A.C., N.P. and P.G. performed the anatomical experiments. D.C., F.C. and P.V.P. contributed to experimental design. P.V.P. and G.M. wrote the manuscript. All the authors edited the manuscript. G.M. conceived and supervised the project.

Corresponding author

Correspondence toGiovanni Marsicano.

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Competing interests

The authors have filed a patent application (European Patent Office, “Compositions targeting CB1 receptor for controlling food intake”, EP09306163.8) that is based, in part, on the results of this study.

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Bellocchio, L., Lafenêtre, P., Cannich, A. et al. Bimodal control of stimulated food intake by the endocannabinoid system.Nat Neurosci 13, 281–283 (2010). https://doi.org/10.1038/nn.2494

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