Gβ5 recruits R7 RGS proteins to GIRK channels to regulate the timing of neuronal inhibitory signaling (original) (raw)

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Acknowledgements

We thank J. Chen for providing the _Gβ5_−/− mice, W. Simonds for the gift of antibodies to Gβ5 and RGS7 and M. Parent for assistance with the hippocampal slicing technique. This work was supported by US National Institutes of Health grants DA021743 (K.A.M.), DA026405 (K.A.M.), EY018139 (K.A.M.), MH061933 (K.W.), DA011806 (K.W.), DA019666 (M.J.T.) and MH078291 (J.C.-S.), a McKnight Land-Grant Award (K.A.M), and an award from the Whitehall Foundation (M.J.T.).

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Authors and Affiliations

  1. Department of Pharmacology, University of Minnesota, Minneapolis, Minnesota, USA
    Keqiang Xie, Kevin L Allen, José Colón-Saez, Kevin Wickman & Kirill A Martemyanov
  2. Department of Neuroscience, University of Minnesota, Minneapolis, Minnesota, USA
    Saïd Kourrich & Mark J Thomas
  3. Department of Psychology, University of Minnesota, Minneapolis, Minnesota, USA
    Saïd Kourrich & Mark J Thomas
  4. Institute of Human Genetics, University of Minnesota, Minneapolis, Minnesota, USA
    Saïd Kourrich & Mark J Thomas

Authors

  1. Keqiang Xie
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  2. Kevin L Allen
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  3. Saïd Kourrich
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  4. José Colón-Saez
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  5. Mark J Thomas
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  6. Kevin Wickman
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  7. Kirill A Martemyanov
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Contributions

K.W., K.A.M., S.K. and M.J.T. designed the experiments, analyzed the data and wrote the manuscript. K.X., K.L.A., S.K., J.C.-S. and K.W. conducted the experiments.

Corresponding authors

Correspondence toKevin Wickman or Kirill A Martemyanov.

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The authors declare no competing financial interests.

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Xie, K., Allen, K., Kourrich, S. et al. Gβ5 recruits R7 RGS proteins to GIRK channels to regulate the timing of neuronal inhibitory signaling.Nat Neurosci 13, 661–663 (2010). https://doi.org/10.1038/nn.2549

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