The habenula is crucial for experience-dependent modification of fear responses in zebrafish (original) (raw)
Change history
17 October 2010
In the version of this article initially published online, there was an error on page 2, right column, second paragraph, 14th line. Here, ‘Mtz’ should read ‘metronidazole’. The supplementary material file was also missing some information from the images. Both errors have been corrected for the print, PDF and HTML versions of this article.
References
- Hikosaka, O. Nat. Rev. Neurosci. 11, 503–513 (2010).
Article CAS Google Scholar - Bianco, I.H. & Wilson, S. Phil. Trans. R. Soc. Lond. B 364, 1005–1020 (2009).
Article Google Scholar - Herkenham, M. & Nauta, W. J. Comp. Neurol. 187, 19–47 (1979).
Article CAS Google Scholar - Ressler, K.J., Paschall, G., Zhou, X. & Davis, M. J. Neurosci. 22, 7892–7902 (2002).
Article CAS Google Scholar - Amo, R. et al. J. Neurosci. 30, 1566–1574 (2010).
Article CAS Google Scholar - Aizawa, H. et al. Curr. Biol. 15, 238–243 (2005).
Article CAS Google Scholar - Wullimann, M.F., Rupp, B. & Reichert, H. Neuroanatomy of the Zebrafish Brain: A Topological Atlas. (Birkhäuser, Boston, 1996).
- Bandler, R., Keay, K., Floyd, N. & Price, J. Brain Res. Bull. 53, 95–104 (2000).
Article CAS Google Scholar - Goto, M., Swanson, L. & Canteras, N. J. Comp. Neurol. 438, 86–122 (2001).
Article CAS Google Scholar - Reti, I.M., Reddy, R., Worley, P. & Baraban, J. J. Neurochem. 82, 935–944 (2002).
Article CAS Google Scholar - Sweeney, S.T., Broadie, K., Keane, J., Niemann, H. & O'Kane, C. Neuron 14, 341–351 (1995).
Article CAS Google Scholar - Eisenberg, M., Kobilo, T., Berman, D. & Dudai, Y. Science 301, 1102–1104 (2003).
Article CAS Google Scholar - Curado, S. et al. Dev. Dyn. 236, 1025–1035 (2007).
Article CAS Google Scholar - Mongeau, R., Miller, G., Chiang, E. & Anderson, D. J. Neurosci. 23, 3855–3868 (2003).
Article CAS Google Scholar - Maier, S.F. & Watkins, L. Neurosci. Biobehav. Rev. 29, 829–841 (2005).
Article CAS Google Scholar
Acknowledgements
We thank Y. Yoshihara, T. Koide and other members of the Yoshihara laboratory for transgenic fish and advice on the behavioral experiments, S. Watanabe for help in setting up the behavioral experiments, N. Copeland for the BAC homologous recombination system, S. Fraser for GAL4VP16 and UAS plasmids, M. Parsons for the UAS:nfsB-mCherry plasmid, A. Thomson for correction of the manuscript and S. Jesuthasan for communication of unpublished data. We are grateful to all of the members of the Okamoto laboratory for support and advice, the Research Resource Center of RIKEN BSI for animal care and the National BioResource Project of Japan for fish strains. This work was supported by Grant-in-Aids from the Ministry of Education, Culture, Sports, Science and Technology of Japan to H.O. and H.A. and by the Core Research for Evolutional Science and Technology of Japan Science and Technology Agency to H.O.
Author information
Author notes
- Takayuki Sassa
Present address: Present address: Laboratory of Biochemistry, Faculty of Pharmaceutical Sciences, Hokkaido University, Higashi, Kita-ku, Sapporo, Japan.,
Authors and Affiliations
- RIKEN Brain Science Institute, Wako, Saitama, Japan
Masakazu Agetsuma, Hidenori Aizawa, Tazu Aoki, Ryoko Nakayama, Mikako Takahoko, Midori Goto, Takayuki Sassa, Ryunosuke Amo, Toshiyuki Shiraki, Toshihiko Hosoya & Hitoshi Okamoto - Research Resource Center, RIKEN Brain Science Institute, Wako, Saitama, Japan
Ryoko Nakayama, Mikako Takahoko & Toshiyuki Shiraki - Department of Life Science and Medical Bioscience, Graduate School of Advanced Science and Engineering, Waseda University, Shinjuku-ku, Tokyo, Japan
Ryunosuke Amo - Division of Molecular and Developmental Biology, and Department of Genetics, National Institute of Genetics, the Graduate University for Advanced Studies, Mishima, Shizuoka, Japan
Koichi Kawakami - National Institutes of Natural Sciences, Okazaki Institute for Integrative Bioscience, National Institute for Physiological Sciences, Okazaki, Aichi, Japan
Shin-ichi Higashijima - Core Research for Evolutional Science and Technology, Japan Science and Technology Agency, Sanbancho, Chiyoda-ku, Tokyo, Japan
Hitoshi Okamoto
Authors
- Masakazu Agetsuma
You can also search for this author inPubMed Google Scholar - Hidenori Aizawa
You can also search for this author inPubMed Google Scholar - Tazu Aoki
You can also search for this author inPubMed Google Scholar - Ryoko Nakayama
You can also search for this author inPubMed Google Scholar - Mikako Takahoko
You can also search for this author inPubMed Google Scholar - Midori Goto
You can also search for this author inPubMed Google Scholar - Takayuki Sassa
You can also search for this author inPubMed Google Scholar - Ryunosuke Amo
You can also search for this author inPubMed Google Scholar - Toshiyuki Shiraki
You can also search for this author inPubMed Google Scholar - Koichi Kawakami
You can also search for this author inPubMed Google Scholar - Toshihiko Hosoya
You can also search for this author inPubMed Google Scholar - Shin-ichi Higashijima
You can also search for this author inPubMed Google Scholar - Hitoshi Okamoto
You can also search for this author inPubMed Google Scholar
Contributions
M.A., H.A. and H.O. designed the experiments and wrote the manuscript. H.O. supervised the research project. M.A. performed most of the experiments using transgenic fish with T.A., R.N., M.T., T. Sassa, T. Shiraki, K.K., T.H. and S.H. H.A. performed the neural tracing study with M.G., M.T. and R.A.
Corresponding author
Correspondence toHitoshi Okamoto.
Ethics declarations
Competing interests
The authors declare no competing financial interests.
Supplementary information
Supplementary Text and Figures
Supplementary Figures 1–24, Supplementary Table 1, Supplementary Methods and Supplementary Data (PDF 4168 kb)
Supplementary Movie 1
Response of the control fish at the first trial of the retrieval session. (MOV 494 kb)
Supplementary Movie 2
Response of the dHbl-silenced fish at the first trial of the retrieval session. (MOV 1138 kb)
Supplementary Movie 3
Persistent rotation of the dHbl-silenced fish at the first trial of the retrieval session. (MOV 581 kb)
Rights and permissions
About this article
Cite this article
Agetsuma, M., Aizawa, H., Aoki, T. et al. The habenula is crucial for experience-dependent modification of fear responses in zebrafish.Nat Neurosci 13, 1354–1356 (2010). https://doi.org/10.1038/nn.2654
- Received: 21 June 2010
- Accepted: 07 September 2010
- Published: 10 October 2010
- Issue Date: November 2010
- DOI: https://doi.org/10.1038/nn.2654