High-accuracy neurite reconstruction for high-throughput neuroanatomy (original) (raw)

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Acknowledgements

We thank B. Andres, F. Hamprecht, U. Köthe, V. Jain, S. Seung and S. Turaga for many fruitful discussions and comments on the manuscript, J. Bollmann and A. Schaefer for helpful comments on the manuscript, C. Roome for information technology support, J. Kornfeld and F. Svara for programming KNOSSOS, and J. Hanne, H. Jakobi and H. Wissler for help with annotator training. We thank N. Abazova, E. Abs, A. Antunes, P. Bastians, J. Bauer, M. Beez, M. Beining, S. Bender, S. Best, L. Brosi, M. Bucher, E. Buckler, J. Buhmann, C. Burkhardt, F. Drawitsch, L. Ehm, S. Ehm, C. Fianke, R. Foltin, S. Freiss, M. Funk, A. Gebhardt, M. Gruen, K. Haase, J. Hammerich, J. Hanne, B. Hauber, M. Hensen, L. Hofmann, P. Hofmann, M. Hülser, F. Isensee, H. Jakobi, M. Jonczyk, A. Joschko, A. Juenger, S. Kaspar, K. Kessler, A. Khan, M. Kiapes, A. Klein, C. Klein, S. Laiouar, T. Lang, L. Lebelt, H. Lesch, C. Lieven, D. Luft, E. Moeller, A. Muellner, M. Mueller, D. Ollech, A. Oppold, T. Otolski, S. Oumohand, S. Pfarr, M. Pohrath, A. Poos, S. Putzke, J. Reinhardt, A. Rommerskirchen, M. Roth, J. Sambel, K. Schramm, C. Sellmann, J. Sieber, I. Sonntag, M. Stahlberg, T. Stratmann, J. Trendel, F. Trogisch, M. Uhrig, A. Vogel, J. Volz, C. Weber, P. Weber, K. Weiss, L. Weisshaar, E. Wiegand, T. Wiegand, M. Wiese, R. Wiggers, C. Willburger and A. Zegarra for neurite skeletonizations. This work was funded by the Max Planck Society.

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Authors and Affiliations

  1. Max Planck Institute for Medical Research, Heidelberg, Germany
    Moritz Helmstaedter, Kevin L Briggman & Winfried Denk

Authors

  1. Moritz Helmstaedter
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  2. Kevin L Briggman
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  3. Winfried Denk
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Contributions

M.H. and W.D. designed the study and devised the analysis algorithms; K.L.B. carried out the SBEM experiments; M.H., K.L.B. and W.D. specified the KNOSSOS software; M.H. analyzed the data; M.H., K.L.B. and W.D. wrote the paper.

Corresponding author

Correspondence toMoritz Helmstaedter.

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Competing interests

Moritz Helmstaedter and Winfried Denk have applied for a patent (Published Patent Application US 20100183217). Winfried Denk receives IP license income from Gatan Inc. for serial blockface imaging.

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Helmstaedter, M., Briggman, K. & Denk, W. High-accuracy neurite reconstruction for high-throughput neuroanatomy.Nat Neurosci 14, 1081–1088 (2011). https://doi.org/10.1038/nn.2868

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