AgRP neurons regulate development of dopamine neuronal plasticity and nonfood-associated behaviors (original) (raw)

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References

  1. Horvath, T.L., Bechmann, I., Naftolin, F., Kalra, S.P. & Leranth, C. Brain Res. 756, 283–286 (1997).
    Article CAS Google Scholar
  2. Luquet, S., Perez, F., Hnasko, T. & Palmiter, R. Science 310, 683–685 (2005).
    Article CAS Google Scholar
  3. Gropp, E. et al. Nat. Neurosci. 8, 1289–1291 (2005).
    Article CAS Google Scholar
  4. Wu, Q., Boyle, M. & Palmiter, R. Cell 137, 1225–1234 (2009).
    Article Google Scholar
  5. Dietrich, M.O. et al. J. Neurosci. 30, 11815–11825 (2010).
    Article CAS Google Scholar
  6. Dulawa, S.C., Grandy, D.K., Low, M.J., Paulus, M.P. & Geyer, M.A. J. Neurosci. 19, 9550–9556 (1999).
    Article CAS Google Scholar
  7. Kazlauckas, V. et al. Behav. Brain Res. 162, 272–278 (2005).
    Article Google Scholar
  8. Tang-Christensen, M. et al. Endocrinology 145, 4645–4652 (2004).
    Article CAS Google Scholar
  9. Broberger, C., Johansen, J., Johansson, C., Schalling, M. & Hokfelt, T. Proc. Natl. Acad. Sci. USA 95, 15043–15048 (1998).
    Article CAS Google Scholar
  10. Wu, Q., Howell, M.P. & Palmiter, R.D. J. Neurosci. 28, 9218–9226 (2008).
    Article CAS Google Scholar
  11. Korotkova, T.M., Brown, R.E., Sergeeva, O.A., Ponomarenko, A.A. & Haas, H.L. Eur. J. Neurosci. 23, 2677–2685 (2006).
    Article CAS Google Scholar
  12. Liu, Q.S., Pu, L. & Poo, M.M. Nature 437, 1027–1031 (2005).
    Article CAS Google Scholar
  13. Brunzell, D.H., Mineur, Y.S., Neve, R.L. & Picciotto, M.R. Neuropsychopharmacology 34, 1993–2001 (2009).
    Article CAS Google Scholar
  14. Abizaid, A. et al. J. Clin. Invest. 116, 3229–3239 (2006).
    Article CAS Google Scholar

Download references

Acknowledgements

We thank L. Kus from the GENSTAT Project, which provided important information on the AgRP-EGFP mouse (MT25), A. Xu for providing breeding pairs of AgRP-Cre mice (University of California San Francisco), R. Palmiter for providing breeding pairs of the AgRP-DTR mice (University of Washington), and the personnel of the Horvath laboratory for support. This work was supported by a US National Institutes of Health Director's Pioneer Award to T.L.H. I.A. was supported by National Institute on Deafness and Other Communication Disorders (US National Institutes of Health) grants. D.O.S. was supported by grants from Financiadora de Estudos e Projetos/Ministério de Ciência e Tecnologia (FINEP/MCT, Brazil) and Instituto Nacional de Ciência e Tecnologia em Excitotoxicidade e Neuroproteção (Brazil). M.O.D. was partially supported by Conselho Nacional de Desenvolvimento Científico e Tecnológico (Brazil).

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Authors and Affiliations

  1. Program in Integrative Cell Signaling and Neurobiology of Metabolism, Section of Comparative Medicine, Yale University School of Medicine, New Haven, Connecticut, USA
    Marcelo O Dietrich, Jeremy Bober, Xiao-Bing Gao, Zhong-Wu Liu & Tamas L Horvath
  2. Department of Biochemistry, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil
    Marcelo O Dietrich & Diogo O Souza
  3. Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut, USA
    Jozélia G Ferreira, Luis A Tellez, Yann S Mineur, Marina R Picciotto & Ivan Araújo
  4. The John B. Pierce Laboratory, New Haven, Connecticut, USA
    Jozélia G Ferreira, Luis A Tellez & Ivan Araújo
  5. Departments of Obstetrics, Gynecology and Reproductive Sciences, Yale University School of Medicine, New Haven, Connecticut, USA
    Tamas L Horvath
  6. Department of Neurobiology, Yale University School of Medicine, New Haven, Connecticut, USA
    Tamas L Horvath

Authors

  1. Marcelo O Dietrich
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  2. Jeremy Bober
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  3. Jozélia G Ferreira
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  4. Luis A Tellez
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  5. Yann S Mineur
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  6. Diogo O Souza
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  7. Xiao-Bing Gao
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  8. Marina R Picciotto
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  9. Ivan Araújo
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  10. Zhong-Wu Liu
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  11. Tamas L Horvath
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Contributions

M.O.D. designed, executed, collected and analyzed all of the data (except for the electrophysiology experiments). Z.-W.L. designed, executed and analyzed the electrophysiology experiments. J.B. help to design and execute the experiments that involved dopamine measurements and immunohistochemistry, and aided with animal maintenance and genotyping. Y.M. helped with the CPP experiment. M.P. helped to design and discussed the experiments and results of the cocaine experiments. J.G.F. and L.A.T. helped with the microdialysis experiment. I.A. designed, discussed and helped analyze the dopamine measurement experiment. D.O.S. helped to design and discussed the behavioral experiments. X.-B.G. helped to design and analyze the electrophysiology experiments. T.L.H. designed and analyzed all of the experiments. M.O.D. and T.L.H. wrote the manuscript.

Corresponding author

Correspondence toTamas L Horvath.

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The authors declare no competing financial interests.

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Dietrich, M., Bober, J., Ferreira, J. et al. AgRP neurons regulate development of dopamine neuronal plasticity and nonfood-associated behaviors.Nat Neurosci 15, 1108–1110 (2012). https://doi.org/10.1038/nn.3147

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