Netrin requires focal adhesion kinase and Src family kinases for axon outgrowth and attraction (original) (raw)

• Hedgecock, E.M., Culotti, J.G. & Hall, D.H. The unc-5, unc-6, and unc-40 genes guide circumferential migrations of pioneer axons and mesodermal cells on the epidermis in C. elegans. Neuron 4, 61–85 (1990).
  Article CAS PubMed Google Scholar
• Kennedy, T.E., Serafini, T., de la Torre, J.R. & Tessier-Lavigne, M. Netrins are diffusible chemotropic factors for commissural axons in the embryonic spinal cord. Cell 78, 425–435 (1994).
  Article CAS PubMed Google Scholar
• Serafini, T. et al. The netrins define a family of axon outgrowth-promoting proteins homologous to C. elegans UNC-6. Cell 78, 409–424 (1994).
  Article CAS PubMed Google Scholar
• Merz, D.C. & Culotti, J.G. Genetic analysis of growth cone migration in Caenorhabditis elegans. J. Neurobiol. 44, 281–288 (2000).
  Article CAS PubMed Google Scholar
• Ishii, N., Wadsworth W.G., Stern, B.D., Culotti, J.G. & Hedgecock, E.M. UNC-6, a laminin-related protein, guides cell and pioneer axon migrations in C. elegans. Neuron 9, 873–881 (1992).
  Article CAS PubMed Google Scholar
• Tessier-Lavigne, M., Placzek, M., Lumsden, A.G., Dodd, J. & Jessell, T.M. Chemotropic guidance of developing axons in the mammalian central nervous system. Nature 336, 775–778 (1988).
  Article CAS PubMed Google Scholar
• Placzek, M., Tessier-Lavigne, M., Jessell, T. & Dodd, J. Orientation of commissural axons in vitro in response to a floor plate-derived chemoattractant. Development 110, 19–30 (1990).
  CAS PubMed Google Scholar
• Bovolenta, P. & Dodd, J. Guidance of commissural growth cones at the floor plate in embryonic rat spinal cord. Development 109, 435–447 (1990).
  CAS PubMed Google Scholar
• Bovolenta, P. & Dodd, J. Perturbation of neuronal differentiation and axon guidance in the spinal cord of mouse embryos lacking a floor plate: analysis of Danforth's short-tail mutation. Development 113, 625–639 (1991).
  CAS PubMed Google Scholar
• Bernhardt, R.R., Nguyen, N. & Kuwada, J.Y. Growth cone guidance by floor plate cells in the spinal cord of zebrafish embryos. Neuron 8, 869–882 (1992).
  Article CAS PubMed Google Scholar
• Harris, R., Sabatelli, L.M. & Seeger, M.A. Guidance cues at the Drosophila CNS midline: identification and characterization of two Drosophila netrin/UNC-6 homologs. Neuron 17, 217–228 (1996).
  Article CAS PubMed Google Scholar
• Kolodziej, P.A. et al. Frazzled encodes a Drosophila member of the DCC immunoglobin subfamily and is required for CNS and motor axon guidance. Cell 87, 197–204 (1996).
  Article CAS PubMed Google Scholar
• Mitchell, K.J. et al. Genetic analysis of Netrin genes in Drosophila: netrins guide CNS commissural axons and peripheral motor axons. Neuron 17, 203–215 (1996).
  Article CAS PubMed Google Scholar
• Wang, H., Copeland, N.G., Gilbert, D.J., Jenkins, N.A. & Tessier-Lavigne, M. Netrin-3, a mouse homolog of human NTN2L, is highly expressed in sensory ganglia and shows differential binding to netrin receptors. J. Neurosci. 19, 4938–4947 (1999).
  Article CAS PubMed PubMed Central Google Scholar
• Koch, M. et al. A novel member of the netrin family, β-netrin, shares homology with the β chain of laminin: identification, expression, and functional characterization. J. Cell Biol. 151, 221–234 (2000).
  Article CAS PubMed PubMed Central Google Scholar
• Hedgecock, E.M., Culotti, J.G., Hall, D.H. & Stern, B.D. Genetics of cell and axon migrations in C. elegans. Development 100, 365–382 (1987).
  CAS PubMed Google Scholar
• Chan, S.S.Y. et al. UNC-40, a C. elegans homolog of DCC (Deleted in Colorectal Cancer), is required in motile cells responding to UNC-6 Netrin cues. Cell 87, 187–195 (1996).
  Article CAS PubMed Google Scholar
• Leung-Hagesteijn, C. et al. UNC-5, a transmembrane protein with immunoglobulin and thrombospondin type 1 domains, guides cell and pioneer axon migrations in C. elegans. Cell 71, 289–299 (1992).
  Article CAS PubMed Google Scholar
• Keino-Masu, K. et al. Deleted in colorectal cancer (DCC) encodes a netrin receptor. Cell 87, 175–185 (1996).
  Article CAS PubMed Google Scholar
• Fazeli, A. et al. Phenotype of mice lacking functional Deleted in colorectal cancer (DCC) gene. Nature 386, 796–804 (1997).
  Article CAS PubMed Google Scholar
• Ackerman, S.L. et al. The mouse rostral cerebellar malformation gene encodes an UNC-5-like protein. Nature 386, 838–842 (1997).
  Article CAS PubMed Google Scholar
• Leonardo, E.D. et al. Vertebrate homologues of C. elegans UNC-5 are candidate netrin receptors. Nature 386, 833–838 (1997).
  Article CAS PubMed Google Scholar
• Przyborski, S.A., Knowles, B.B. & Ackerman, S.L. Embryonic phenotype of Unc5h3 mutant mice suggests chemorepulsion during the formation of the rostral cerebellar boundary. Development 125, 41–50 (1998).
  CAS PubMed Google Scholar
• Engelkamp, D. Cloning of three mouse Unc5 genes and their expression patterns at mid-gestation. Mech. Dev. 118, 191–197 (2002).
  Article CAS PubMed Google Scholar
• Hamelin, M., Zhou, Y., Su, M.-W., Scott, I.M. & Culotti, J.G. Expression of the UNC-5 guidance receptor in the touch neurons of C. elegans steers their axons dorsally. Nature 364, 327–330 (1993).
  Article CAS PubMed Google Scholar
• de la Torre, J.R. et al. Turning of retinal growth cones in a netrin-1 gradient mediated by the netrin receptor DCC. Neuron 19, 1211–1224 (1997).
  Article CAS PubMed Google Scholar
• Hong, K. et al. A ligand-gated association between cytoplasmic domains of UNC5 and DCC family receptors converts netrin-induced growth cone attraction to repulsion. Cell 97, 927–941 (1999).
  Article CAS PubMed Google Scholar
• Merz, D.C., Zheng, H., Killeen, M.T., Krizus, A. & Culotti, J.G. Multiple signaling mechanisms of the unc-6/netrin receptors unc-5 and unc-40/dcc in vivo. Genetics 158, 1071–1080 (2001).
  CAS PubMed PubMed Central Google Scholar
• Colavita, A. & Culotti, J.G. Suppressors of ectopic UNC-5 growth cone steering identify eight genes involved in axon guidance in Caenorhabditis elegans. Dev. Biol. 194, 72–85 (1998).
  Article CAS PubMed Google Scholar
• Huang, X., Cheng, H.-J., Tessier-Lavigne, M. & Jin, Y. MAX-1, a novel PH/MyTH4/FERM domain cytoplasmic protein implicated in netrin-mediated axon repulsion. Neuron 34, 563–576 (2002).
  Article CAS PubMed Google Scholar
• Ming, G.L. et al. Adaptation in the chemotactic guidance of nerve growth cones. Nature 417, 411–418 (2002).
  Article CAS PubMed Google Scholar
• Forcet, C. et al. Netrin-1-mediated axon outgrowth requires deleted in colorectal cancer-dependent MAPK activation. Nature 417, 443–447 (2002).
  Article CAS PubMed Google Scholar
• Campbell, D.S. & Holt, C.E. Apoptotic pathway and MAPKs differentially regulate chemotropic responses of retinal growth cones. Neuron 37, 939–952 (2003).
  Article CAS PubMed Google Scholar
• Shekarabi, M. & Kennedy, T.E. The netrin-1 receptor DCC promotes filopodia formation and cell spreading by activating Cdc42 and Rac1. Mol. Cell. Neurosci. 19, 1–17 (2002).
  Article CAS PubMed Google Scholar
• Li, X. Saint-Cyr-Proulx, E., Aktories, K. & Lamarche-Vane, N. Rac1 and Cdc42 but not RhoA or Rho kinase activities are required for neurite outgrowth induced by the Netrin-1 receptor DCC (deleted in colorectal cancer) in N1E-115 neuroblastoma cells. J. Biol. Chem. 277, 15207–15214 (2002).
  Article CAS PubMed Google Scholar
• Guan, J.L, Trevithick, J.E. & Hynes, R.O. Fibronectin/integrin interaction induces tyrosine phosphorylation of a 120-kDa protein. Cell Regul. 2, 951–964 (1991).
  Article CAS PubMed PubMed Central Google Scholar
• Kornberg, L., Earp, S.E., Turner, C.E., Procktop, C. & Juliano, R.L. Signal transduction by integrins: increased protein tyrosine phosphorylation caused by clustering of β1 integrins. Proc. Natl. Acad. Sci. USA 88, 8392–8396 (1991).
  Article CAS PubMed PubMed Central Google Scholar
• Guan, J.L. & Shalloway, D. Regulation of focal adhesion-associated protein tyrosine kinase by both cellular adhesion and oncogenic transformation. Nature 358, 690–692 (1992).
  Article CAS PubMed Google Scholar
• Hanks, S.K., Calalb, M.B., Harper, M.C. & Patel, S.K. Focal adhesion protein tyrosine kinase on fibronectin. Proc. Natl. Acad. Sci. USA 89, 8487–8491 (1992).
  Article CAS PubMed PubMed Central Google Scholar
• Schaller, M.D., Borgman, C.A., Cobb, B.S., Reynolds, A.B. & Parsons, J.T. pp125FAK, a structurally distinctive protein tyrosine kinase associated with focal adhesions. Proc. Natl. Acad. Sci. USA 89, 5192–5196 (1992).
  Article CAS PubMed PubMed Central Google Scholar
• Parsons, J.T. Focal adhesion kinase: the first ten years. J. Cell Sci. 116, 1409–1416 (2003).
  Article CAS PubMed Google Scholar
• Wong, K. et al. Signal transduction in neuronal migration: roles of GTPase activating proteins and the small GTPase Cdc42 in the Slit-Robo pathway. Cell 107, 209–221 (2001).
  Article CAS PubMed Google Scholar
• Colamarino, S.A. & Tessier-Lavigne, M. The axonal chemoattractant netrin-1 is also a chemorepellent for trochlear motor axons. Cell 81, 621–629 (1995).
  Article CAS PubMed Google Scholar
• Richards, L.J., Koester, S.E., Tuttle, R. & O'Leary, D.D. Directed growth of early cortical axons is influenced by a chemoattractant released from an intermediate target. J. Neurosci. 17, 2445–2458 (1997).
  Article CAS PubMed PubMed Central Google Scholar
• Beggs, H.E. et al. FAK deficiency in cells contributing to the basal lamina results in cortical abnormalities resembling congenital muscular dystrophies. Neuron 40, 501–514 (2003).
  Article CAS PubMed PubMed Central Google Scholar
• Li, W. et al. Activation of FAK and Src are receptor-proximal events required for netrin signaling. Nat. Neurosci. 7, 1213–1221 (2004).
  Article CAS PubMed PubMed Central Google Scholar
• Ren, X.-R. et al. Focal adhesion kinase in netrin-1 signaling. Nat. Neurosci. 7, 1204–1212 (2004).
  Article CAS PubMed Google Scholar
• Ming, G.L. et al. Phospholipase C-γ and phosphoinositide 3-kinase mediate cytoplasmic signaling in nerve growth cone guidance. Neuron 23, 139–148 (1999).
  Article CAS PubMed Google Scholar
• Tong, J. et al. Netrin stimulates tyrosine phosphorylation of the UNC-5 family of netrin receptors and induces Shp2 binding to the RCM cytodomain. J. Biol. Chem. 276, 40917–40925 (2001).
  Article CAS PubMed Google Scholar
• Killeen, M. et al. UNC-5 function requires phosphorylation of cytoplasmic tyrosine 482, but its UNC-40-independent functions also require a region between the ZU-5 and death domains. Dev. Biol. 251, 348–366 (2002).
  Article CAS PubMed Google Scholar