Topographic mapping of VMH → arcuate nucleus microcircuits and their reorganization by fasting (original) (raw)

References

  1. Kennedy, G.C. The hypothalamic control of food intake in rats. Proc. R. Soc. Lond. B 137, 535–549 (1950).
    Article CAS PubMed Google Scholar
  2. Hetherington, A.W. & Ranson, S.W. Hypothalamic lesions and adiposity in the rat. Anat. Rec. 78, 149–161 (1940).
    Article Google Scholar
  3. Anand, B.K. & Brobeck, J.R. Hypothalamic control of food intake in rats and cats. Yale J. Biol. Med. 24, 123–140 (1951).
    CAS PubMed Central PubMed Google Scholar
  4. Majdic, G. et al. Knockout mice lacking steroidogenic factor 1 are a novel genetic model of hypothalamic obesity. Endocrinology 143, 607–614 (2002).
    Article CAS PubMed Google Scholar
  5. Elmquist, J.K., Elias, C.F. & Saper, C.B. From lesions to leptin: hypothalamic control of food intake and body weight. Neuron 22, 221–232 (1999).
    Article CAS PubMed Google Scholar
  6. Clark, J.T., Kalra, P.S., Crowley, W.R. & Kalra, S.P. Neuropeptide Y and human pancreatic polypeptide stimulate feeding behavior in rats. Endocrinology 115, 427–429 (1984).
    Article CAS PubMed Google Scholar
  7. Zarjevski, N., Cusin, I., Vettor, R., Rohner-Jeanrenaud, F. & Jeanrenaud, B. Chronic intracerebroventricular neuropeptide-Y administration to normal rats mimics hormonal and metabolic changes of obesity. Endocrinology 133, 1753–1758 (1993).
    Article CAS PubMed Google Scholar
  8. Huszar, D. et al. Targeted disruption of the melanocortin-4 receptor results in obesity in mice. Cell 88, 131–141 (1997).
    Article CAS PubMed Google Scholar
  9. Fan, W., Boston, B.A., Kesterson, R.A., Hruby, V.J. & Cone, R.D. Role of melanocortinergic neurons in feeding and the agouti obesity syndrome. Nature 385, 165–168 (1997).
    Article CAS PubMed Google Scholar
  10. Pinto, S. et al. Rapid rewiring of arcuate nucleus feeding circuits by leptin. Science 304, 110–115 (2004).
    Article CAS PubMed Google Scholar
  11. DeFalco, J. et al. Virus-assisted mapping of neural inputs to a feeding center in the hypothalamus. Science 291, 2608–2613 (2001).
    Article CAS PubMed Google Scholar
  12. Canteras, N.S., Simerly, R.B. & Swanson, L.W. Organization of projections from the ventromedial nucleus of the hypothalamus: a Phaseolus vulgaris-leucoagglutinin study in the rat. J. Comp. Neurol. 348, 41–79 (1994).
    Article CAS PubMed Google Scholar
  13. van den Pol, A.N. & Cassidy, J.R. The hypothalamic arcuate nucleus of rat–a quantitative Golgi analysis. J. Comp. Neurol. 204, 65–98 (1982).
    Article CAS PubMed Google Scholar
  14. Callaway, E.M. & Katz, L.C. Photostimulation using caged glutamate reveals functional circuitry in living brain slices. Proc. Natl. Acad. Sci. USA 90, 7661–7665 (1993).
    Article CAS PubMed PubMed Central Google Scholar
  15. Sawatari, A. & Callaway, E.M. Convergence of magno- and parvocellular pathways in layer 4B of macaque primary visual cortex. Nature 380, 442–446 (1996).
    Article CAS PubMed Google Scholar
  16. Dantzker, J.L. & Callaway, E.M. Laminar sources of synaptic input to cortical inhibitory interneurons and pyramidal neurons. Nat. Neurosci. 3, 701–707 (2000).
    Article CAS PubMed Google Scholar
  17. Shepherd, G.M., Pologruto, T.A. & Svoboda, K. Circuit analysis of experience-dependent plasticity in the developing rat barrel cortex. Neuron 38, 277–289 (2003).
    Article CAS PubMed Google Scholar
  18. Brivanlou, I.H., Dantzker, J.L., Stevens, C.F. & Callaway, E.M. Topographic specificity of functional connections from hippocampal CA3 to CA1. Proc. Natl. Acad. Sci. USA 101, 2560–2565 (2004).
    Article CAS PubMed PubMed Central Google Scholar
  19. Yoshimura, Y., Dantzker, J.L. & Callaway, E.M. Excitatory cortical neurons form fine-scale functional networks. Nature 433, 868–873 (2005).
    Article CAS PubMed Google Scholar
  20. Shepherd, G.M., Stepanyants, A., Bureau, I., Chklovskii, D. & Svoboda, K. Geometric and functional organization of cortical circuits. Nat. Neurosci. 8, 782–790 (2005).
    Article CAS PubMed Google Scholar
  21. Callaway, E.M. Cell type specificity of local cortical connections. J. Neurocytol. 31, 231–237 (2002).
    Article CAS PubMed Google Scholar
  22. Cowley, M.A. et al. Leptin activates anorexigenic POMC neurons through a neural network in the arcuate nucleus. Nature 411, 480–484 (2001).
    Article CAS PubMed Google Scholar
  23. Ahima, R.S. et al. Role of leptin in the neuroendocrine response to fasting. Nature 382, 250–252 (1996).
    Article CAS PubMed Google Scholar
  24. Faletti, A.G. et al. beta-Endorphin blocks luteinizing hormone-releasing hormone release by inhibiting the nitricoxidergic pathway controlling its release. Proc. Natl. Acad. Sci. USA 96, 1722–1726 (1999).
    Article CAS PubMed PubMed Central Google Scholar
  25. Kreek, M.J. Methadone-related opioid agonist pharmacotherapy for heroin addiction. History, recent molecular and neurochemical research and future in mainstream medicine. Ann. NY Acad. Sci. 909, 186–216 (2000).
    Article CAS PubMed Google Scholar
  26. Shimizu, N., Oomura, Y., Plata-Salaman, C.R. & Morimoto, M. Hyperphagia and obesity in rats with bilateral ibotenic acid-induced lesions of the ventromedial hypothalamic nucleus. Brain Res. 416, 153–156 (1987).
    Article CAS PubMed Google Scholar
  27. Stenger, J., Fournier, T. & Bielajew, C. The effects of chronic ventromedial hypothalamic stimulation on weight gain in rats. Physiol. Behav. 50, 1209–1213 (1991).
    Article CAS PubMed Google Scholar
  28. Elmquist, J.K., Bjorbaek, C., Ahima, R.S., Flier, J.S. & Saper, C.B. Distributions of leptin receptor mRNA isoforms in the rat brain. J. Comp. Neurol. 395, 535–547 (1998).
    Article CAS PubMed Google Scholar
  29. Ono, T. et al. Glucoresponsive neurons in rat ventromedial hypothalamic tissue slices in vitro . Brain Res. 232, 494–499 (1982).
    Article CAS PubMed Google Scholar
  30. Christensen, L.W., Nance, D.M. & Gorski, R.A. Effects of hypothalamic and preoptic lesions on reproductive behavior in male rats. Brain Res. Bull. 2, 137–141 (1977).
    Article CAS PubMed Google Scholar
  31. Pfaff, D.W. & Sakuma, Y. Deficit in the lordosis reflex of female rats caused by lesions in the ventromedial nucleus of the hypothalamus. J. Physiol. (Lond.) 288, 203–210 (1979).
    CAS Google Scholar
  32. Theodosis, D.T. & Poulain, D.A. Activity-dependent neuronal-glial and synaptic plasticity in the adult mammalian hypothalamus. Neuroscience 57, 501–535 (1993).
    Article CAS PubMed Google Scholar
  33. Bouret, S.G., Draper, S.J. & Simerly, R.B. Trophic action of leptin on hypothalamic neurons that regulate feeding. Science 304, 108–110 (2004).
    Article CAS PubMed Google Scholar
  34. Slimko, E.M., McKinney, S., Anderson, D.J., Davidson, N. & Lester, H.A. Selective electrical silencing of mammalian neurons in vitro by the use of invertebrate ligand-gated chloride channels. J. Neurosci. 22, 7373–7379 (2002).
    Article CAS PubMed PubMed Central Google Scholar
  35. Lechner, H.A., Lein, E.S. & Callaway, E.M. A genetic method for selective and quickly reversible silencing of Mammalian neurons. J. Neurosci. 22, 5287–5290 (2002).
    Article CAS PubMed PubMed Central Google Scholar

Download references