Amygdala BDNF signaling is required for consolidation but not encoding of extinction (original) (raw)

Nature Neuroscience volume 9, pages 870–872 (2006)Cite this article

Abstract

Brain-derived neurotrophic factor (BDNF) acting through the tyrosine kinase B receptor (TrkB) is thought to be a critical mediator of learning. As there are no available selective antagonists of TrkB, we used a lentivirus encoding a dominant-negative TrkB (TrkB.t1) to antagonize BDNF signaling during extinction of conditioned fear. Whereas TrkB.t1-infected rats showed normal within-session extinction, their retention of extinction was impaired, suggesting that amygdala TrkB activation is required for the consolidation of stable extinction memories.

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Acknowledgements

Support was provided by the US National Institutes of Health (MH47840 to M.D., MH069884 to K.J.R. and MH070218 to J.P.C.), the National Alliance for Research on Schizophrenia and Depression (NARSAD; K.J.R.), NIH/NCRR base grant (P51RR000165) to Yerkes National Primates Research Center and the Center for Behavioral Neuroscience (National Science Foundation agreement IBN-987675).

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Authors and Affiliations

  1. Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, 1639 Pierce Drive, Suite 4000, Atlanta, 30322, Georgia, USA
    Jasmeer P Chhatwal, Lisa Stanek-Rattiner, Michael Davis & Kerry J Ressler
  2. Center for Behavioral Neuroscience, Yerkes Research Center, 954 Gatewood Road, Atlanta, 30329, Georgia, USA
    Jasmeer P Chhatwal, Lisa Stanek-Rattiner, Michael Davis & Kerry J Ressler

Authors

  1. Jasmeer P Chhatwal
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  2. Lisa Stanek-Rattiner
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  3. Michael Davis
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  4. Kerry J Ressler
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Correspondence toKerry J Ressler.

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Chhatwal, J., Stanek-Rattiner, L., Davis, M. et al. Amygdala BDNF signaling is required for consolidation but not encoding of extinction.Nat Neurosci 9, 870–872 (2006). https://doi.org/10.1038/nn1718

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