Local caspase activity directs engulfment of dendrites during pruning (original) (raw)

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Acknowledgements

We thank M. Schubiger for helpful discussions; T. Awasaki for informing us about the second site mutation on the draper Δ5 chromosome; E. Baehrecke (University of Maryland Biotechnology Institute, College Park, Maryland), S. Kumar (Hanson Institute and Institute of Medical and Veterinary Science Adelaide, Australia), P. Meier (Institute of Cancer Research, London), W. Grueber (Columbia University, New York), J. Abrams (University of Texas/Southwestern Medical Center, Dallas), W. Johnson (University of Iowa, Iowa City, Iowa), G. Schubiger and S. McNabb (University of Washington, Seattle), M. Freeman (University of Massachusetts Medical School, Worcester, Massachusetts) and the Bloomington Drosophila Stock Center at Indiana University for fly stocks; A. Miyawaki (RIKEN Brain Science Institute, Saitama, Japan) for plasmids; and S. Lennox for technical assistance. Research was supported by grants from the US National Institutes of Health (NS-029971), the Medical Research Council and the CREST program of the Japan Science and Technology Agency.

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Authors and Affiliations

  1. MRC Centre for Developmental Neurobiology, King's College London, London, SE1 1UL, UK
    Darren W Williams & Agnieszka Krzyzanowska
  2. Department of Biology, University of Washington, Seattle, 98195, Washington, USA
    Darren W Williams & James W Truman
  3. Department of Developmental Genetics, National Institute of Genetics, Mishima, 411-8540, Shizuoka, Japan
    Shu Kondo & Yasushi Hiromi
  4. CREST, Japan Science and Technology Agency, National Institute of Genetics, Mishima, 411-8540, Shizuoka, Japan
    Shu Kondo & Yasushi Hiromi
  5. Department of Genetics, SOKENDAI, Mishima, 411-8540, Shizuoka, Japan
    Shu Kondo & Yasushi Hiromi
  6. Division of Morphology and Organogenesis, Institute of DNA Medicine, Jikei University School of Medicine, Tokyo, 105-8461, Japan
    Shu Kondo

Authors

  1. Darren W Williams
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  2. Shu Kondo
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  3. Agnieszka Krzyzanowska
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  4. Yasushi Hiromi
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  5. James W Truman
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Contributions

D.W.W. designed the study, conducted the experimental work, interpreted the data and wrote the manuscript. A.K. generated the adult viable draper Δ5 chromosome and assisted with experimental work. S.K. designed and built the caspase probe, helped interpret data and assisted in writing the manuscript. Y.H. and J.W.T. contributed to experimental design, data interpretation and writing of the manuscript.

Corresponding author

Correspondence toDarren W Williams.

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The authors declare no competing financial interests.

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Williams, D., Kondo, S., Krzyzanowska, A. et al. Local caspase activity directs engulfment of dendrites during pruning.Nat Neurosci 9, 1234–1236 (2006). https://doi.org/10.1038/nn1774

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