Molecular genetic visualization of a rare subset of unmyelinated sensory neurons that may detect gentle touch (original) (raw)

This is a preview of subscription content, access via your institution

References

  1. Dong, X., Han, S., Zylka, M.J., Simon, M.I. & Anderson, D.J. Cell 106, 619–632 (2001).
    Article CAS Google Scholar
  2. Lembo, P.M. et al. Nat. Neurosci. 5, 201–209 (2002).
    Article CAS Google Scholar
  3. Han, S.K. et al. Proc. Natl. Acad. Sci. USA 99, 14740–14745 (2002).
    Article CAS Google Scholar
  4. Zylka, M.J., Dong, X., Southwell, A.L. & Anderson, D.J. Proc. Natl. Acad. Sci. USA 100, 10043–10048 (2003).
    Article CAS Google Scholar
  5. Zylka, M.J., Rice, F.L. & Anderson, D.J. Neuron 45, 17–25 (2005).
    Article CAS Google Scholar
  6. Zotterman, Y. J. Physiol. (Lond.) 95, 1–28 (1939).
    Article CAS Google Scholar
  7. Lawson, S.N., Crepps, B. & Perl, E.R. J. Physiol. (Lond.) 540, 989–1002 (2002).
    Article CAS Google Scholar
  8. Seno, N. & Dray, A. Neuroscience 55, 563–569 (1993).
    Article CAS Google Scholar
  9. Vallbo, A.B., Olausson, H. & Wessberg, J. J. Neurophysiol. 81, 2753–2763 (1999).
    Article CAS Google Scholar
  10. Olausson, H. et al. Nat. Neurosci. 5, 900–904 (2002).
    Article CAS Google Scholar
  11. Wessberg, J., Olausson, H., Fernstrom, K.W. & Vallbo, A.B. J. Neurophysiol. 89, 1567–1575 (2003).
    Article Google Scholar
  12. Kumazawa, T. & Perl, E.R. J. Physiol. (Paris) 73, 287–304 (1977).
    CAS Google Scholar
  13. Sugiura, Y., Lee, C.L. & Perl, E.R. Science 234, 358–361 (1986).
    Article CAS Google Scholar
  14. Schmidt, R., Schmelz, M., Weidner, C., Handwerker, H.O. & Torebjork, H.E. J. Neurophysiol. 88, 1859–1866 (2002).
    Article CAS Google Scholar
  15. Habler, H.-J., Timmermann, L., Stegmann, J.-U. & Janig, W. Neuroscience 89, 1259–1268 (1999).
    Article CAS Google Scholar

Download references

Acknowledgements

We thank S. Pease for mouse assistance and J. Edens for electron microscopy. This work was supported by Alfred P. Sloan Neuroscience and Whitehall Foundation grants (X.D. and M.J.Z.), a Blaustein Pain research fund award (XD) and a European Molecular Biology Organization fellowship (S.V.). D.J.A. is an Investigator of the Howard Hughes Medical Institute.

Author information

Authors and Affiliations

  1. The Solomon H. Snyder Department of Neuroscience, School of Medicine, Johns Hopkins University, 725 N. Wolfe St., Baltimore, Maryland, 21205, USA.,
    Qin Liu & Xinzhong Dong
  2. Division of Biology, 216-76, California Institute of Technology, 1201 E. California Blvd., Pasadena, 91125, California, USA
    Sophia Vrontou & David J Anderson
  3. Howard Hughes Medical Institute, 1201 E. California Blvd., Pasadena, 91125, California, USA
    Sophia Vrontou & David J Anderson
  4. Center for Neuropharmacology and Neuroscience, Albany Medical College, 43 New Scotland Ave., Albany, 12208, New York, USA
    Frank L Rice
  5. Department of Cell and Molecular Physiology, UNC Neuroscience Center, University of North Carolina, 105 Mason Farm Road, Chapel Hill, 27599, North Carolina, USA
    Mark J Zylka

Authors

  1. Qin Liu
    You can also search for this author inPubMed Google Scholar
  2. Sophia Vrontou
    You can also search for this author inPubMed Google Scholar
  3. Frank L Rice
    You can also search for this author inPubMed Google Scholar
  4. Mark J Zylka
    You can also search for this author inPubMed Google Scholar
  5. Xinzhong Dong
    You can also search for this author inPubMed Google Scholar
  6. David J Anderson
    You can also search for this author inPubMed Google Scholar

Contributions

X.D. generated the MrgprB4-PLAP mice, Q.L. carried out the bulk of the immunohistochemical characterization and analysis of these mice, S.V. contributed to the initial analysis and participated in the electron microscopic PLAP experiments, M.J.Z. generated and analyzed MrgprDPLAP/EGFP spinal cord, F.L.R. provided expert advice on interpretation of epidermal innervation and D.J.A. supervised the project and wrote the manuscript.

Corresponding authors

Correspondence toXinzhong Dong or David J Anderson.

Ethics declarations

Competing interests

The authors declare no competing financial interests.

Supplementary information

Rights and permissions

About this article

Cite this article

Liu, Q., Vrontou, S., Rice, F. et al. Molecular genetic visualization of a rare subset of unmyelinated sensory neurons that may detect gentle touch.Nat Neurosci 10, 946–948 (2007). https://doi.org/10.1038/nn1937

Download citation