Activation of EGFR and ERK by rhomboid signaling regulates the consolidation and maintenance of sleep in Drosophila (original) (raw)

References

1. Hendricks, J.C. et al. Rest in Drosophila is a sleep-like state. Neuron 25, 129–138 (2000).
   Article CAS PubMed Google Scholar
2. Shaw, P.J., Cirelli, C., Greenspan, R.J. & Tononi, G. Correlates of sleep and waking in Drosophila melanogaster. Science 287, 1834–1837 (2000).
   Article CAS PubMed Google Scholar
3. Andretic, R., van Swinderen, B. & Greenspan, R.J. Dopaminergic modulation of arousal in Drosophila. Curr. Biol. 15, 1165–1175 (2005).
   Article CAS PubMed Google Scholar
4. Koh, K., Evans, J.M., Hendricks, J.C. & Sehgal, A. A Drosophila model for age-associated changes in sleep:wake cycles. Proc. Natl. Acad. Sci. USA 103, 13843–13847 (2006).
   Article CAS PubMed PubMed Central Google Scholar
5. Kramer, A. et al. Regulation of daily locomotor activity and sleep by hypothalamic EGF receptor signaling. Science 294, 2511–2515 (2001).
   Article CAS PubMed Google Scholar
6. Kushikata, T., Fang, J., Chen, Z., Wang, Y. & Krueger, J.M. Epidermal growth factor enhances spontaneous sleep in rabbits. Am. J. Physiol. 275, R509–R514 (1998).
   CAS PubMed Google Scholar
7. Urban, S., Lee, J.R. & Freeman, M. A family of Rhomboid intramembrane proteases activates all Drosophila membrane-tethered EGF ligands. EMBO J. 21, 4277–4286 (2002).
   Article CAS PubMed PubMed Central Google Scholar
8. Shilo, B.Z. Signaling by the Drosophila epidermal growth factor receptor pathway during development. Exp. Cell Res. 284, 140–149 (2003).
   Article CAS PubMed Google Scholar
9. Shilo, B.Z. Regulating the dynamics of EGF receptor signaling in space and time. Development 132, 4017–4027 (2005).
   Article CAS PubMed Google Scholar
10. Guichard, A. et al. Rhomboid and Star interact synergistically to promote EGFR/MAPK signaling during Drosophila wing vein development. Development 126, 2663–2676 (1999).
    CAS PubMed Google Scholar
11. Brand, A.H. & Perrimon, N. Targeted gene expression as a means of altering cell fates and generating dominant phenotypes. Development 118, 401–415 (1993).
    CAS PubMed Google Scholar
12. Sturtevant, M.A., Roark, M. & Bier, E. The Drosophila rhomboid gene mediates the localized formation of wing veins and interacts genetically with components of the EGFR signaling pathway. Genes Dev. 7, 961–973 (1993).
    Article CAS PubMed Google Scholar
13. Schweitzer, R., Shaharabany, M., Seger, R. & Shilo, B.Z. Secreted Spitz triggers the DER signaling pathway and is a limiting component in embryonic ventral ectoderm determination. Genes Dev. 9, 1518–1529 (1995).
    Article CAS PubMed Google Scholar
14. Freeman, M. Reiterative use of the EGF receptor triggers differentiation of all cell types in the Drosophila eye. Cell 87, 651–660 (1996).
    Article CAS PubMed Google Scholar
15. Urban, S., Lee, J.R. & Freeman, M. Drosophila rhomboid-1 defines a family of putative intramembrane serine proteases. Cell 107, 173–182 (2001).
    Article CAS PubMed Google Scholar
16. Guichard, A., Srinivasan, S., Zimm, G. & Bier, E. A screen for dominant mutations applied to components in the Drosophila EGFR pathway. Proc. Natl. Acad. Sci. USA 99, 3752–3757 (2002).
    Article CAS PubMed PubMed Central Google Scholar
17. McGuire, S.E., Le, P.T., Osborn, A.J., Matsumoto, K. & Davis, R.L. Spatiotemporal rescue of memory dysfunction in Drosophila. Science 302, 1765–1768 (2003).
    Article CAS PubMed Google Scholar
18. Sturtevant, M.A., O'Neill, J.W. & Bier, E. Down-regulation of Drosophila EGFR mRNA levels following hyperactivated receptor signaling. Development 120, 2593–2600 (1994).
    CAS PubMed Google Scholar
19. Welsh, J.B., Gill, G.N., Rosenfeld, M.G. & Wells, A. A negative feedback loop attenuates EGF-induced morphological changes. J. Cell Biol. 114, 533–543 (1991).
    Article CAS PubMed Google Scholar
20. Wiley, H.S. et al. The role of tyrosine kinase activity in endocytosis, compartmentation, and down-regulation of the epidermal growth factor receptor. J. Biol. Chem. 266, 11083–11094 (1991).
    CAS PubMed Google Scholar
21. Ng, D.C. & Bogoyevitch, M.A. The mechanism of heat shock activation of ERK mitogen-activated protein kinases in the interleukin 3–dependent ProB cell line BaF3. J. Biol. Chem. 275, 40856–40866 (2000).
    Article CAS PubMed Google Scholar
22. Williams, J.A., Su, H.S., Bernards, A., Field, J. & Sehgal, A. A circadian output in Drosophila mediated by neurofibromatosis-1 and Ras/MAPK. Science 293, 2251–2256 (2001).
    Article CAS PubMed Google Scholar
23. Schejter, E.D., Segal, D., Glazer, L. & Shilo, B.Z. Alternative 5′ exons and tissue-specific expression of the Drosophila EGF receptor homolog transcripts. Cell 46, 1091–1101 (1986).
    Article CAS PubMed Google Scholar
24. Botella, J.A. et al. Deregulation of the Egfr/Ras signaling pathway induces age-related brain degeneration in the Drosophila mutant vap. Mol. Biol. Cell 14, 241–250 (2003).
    Article CAS PubMed PubMed Central Google Scholar
25. Joiner, W.J., Crocker, A., White, B.H. & Sehgal, A. Sleep in Drosophila is regulated by adult mushroom bodies. Nature 441, 757–760 (2006).
    Article CAS PubMed Google Scholar
26. Pitman, J.L., McGill, J.J., Keegan, K.P. & Allada, R. A dynamic role for the mushroom bodies in promoting sleep in Drosophila. Nature 441, 753–756 (2006).
    Article CAS PubMed Google Scholar
27. Rajashekhar, K.P. & Singh, R.N. Neuroarchitecture of the tritocerebrum of Drosophila melanogaster. J. Comp. Neurol. 349, 633–645 (1994).
    Article CAS PubMed Google Scholar
28. Siegmund, T. & Korge, G. Innervation of the ring gland of Drosophila melanogaster. J. Comp. Neurol. 431, 481–491 (2001).
    Article CAS PubMed Google Scholar
29. de Velasco, B. et al. Specification and development of the pars intercerebralis and pars lateralis, neurocndocrine command centers in the Drosophila brain. Dev. Biol. 302, 309–323 (2007).
    Article CAS PubMed Google Scholar
30. Veelaert, D., Schoofs, L. & De Loof, A. Peptidergic control of the corpus cardiacum-corpora allata complex of locusts. Int. Rev. Cytol. 182, 249–302 (1998).
    Article CAS PubMed Google Scholar
31. De Velasco, B., Shen, J., Go, S. & Hartenstein, V. Embryonic development of the Drosophila corpus cardiacum, a neuroendocrine gland with similarity to the vertebrate pituitary, is controlled by sine oculis and glass. Dev. Biol. 274, 280–294 (2004).
    Article CAS PubMed Google Scholar
32. Kilduff, T.S. & Peyron, C. The hypocretin/orexin ligand-receptor system: implications for sleep and sleep disorders. Trends Neurosci. 23, 359–365 (2000).
    Article CAS PubMed Google Scholar
33. Saper, C.B., Scammell, T.E. & Lu, J. Hypothalamic regulation of sleep and circadian rhythms. Nature 437, 1257–1263 (2005).
    Article CAS PubMed Google Scholar
34. Mignot, E., Taheri, S. & Nishino, S. Sleeping with the hypothalamus: emerging therapeutic targets for sleep disorders. Nat. Neurosci. 5 Suppl, 1071–1075 (2002).
    Article CAS PubMed Google Scholar
35. Saper, C.B., Chou, T.C. & Scammell, T.E. The sleep switch: hypothalamic control of sleep and wakefulness. Trends Neurosci. 24, 726–731 (2001).
    Article CAS PubMed Google Scholar
36. Yarden, Y. & Sliwkowski, M.X. Untangling the ErbB signalling network. Nat. Rev. Mol. Cell Biol. 2, 127–137 (2001).
    Article CAS PubMed Google Scholar
37. Garcia, R.A., Vasudevan, K. & Buonanno, A. The neuregulin receptor ErbB-4 interacts with PDZ-containing proteins at neuronal synapses. Proc. Natl. Acad. Sci. USA 97, 3596–3601 (2000).
    Article CAS PubMed PubMed Central Google Scholar
38. Huang, Y.Z. et al. Regulation of neuregulin signaling by PSD-95 interacting with ErbB4 at CNS synapses. Neuron 26, 443–455 (2000).
    Article CAS PubMed Google Scholar
39. Suzuki, T., Okumura-Noji, K. & Nishida, E. ERK2-type mitogen-activated protein kinase (MAPK) and its substrates in postsynaptic density fractions from the rat brain. Neurosci. Res. 22, 277–285 (1995).
    Article CAS PubMed Google Scholar
40. Suzuki, T., Mitake, S. & Murata, S. Presence of upstream and downstream components of a mitogen-activated protein kinase pathway in the PSD of the rat forebrain. Brain Res. 840, 36–44 (1999).
    Article CAS PubMed Google Scholar
41. Humbert, P., Russell, S. & Richardson, H. Dlg, Scribble and Lgl in cell polarity, cell proliferation and cancer. Bioessays 25, 542–553 (2003).
    Article CAS PubMed Google Scholar
42. Hoeffer, C.A., Sanyal, S. & Ramaswami, M. Acute induction of conserved synaptic signaling pathways in Drosophila melanogaster. J. Neurosci. 23, 6362–6372 (2003).
    Article CAS PubMed PubMed Central Google Scholar
43. Sweatt, J.D. Mitogen-activated protein kinases in synaptic plasticity and memory. Curr. Opin. Neurobiol. 14, 311–317 (2004).
    Article CAS PubMed Google Scholar
44. Schrader, L.A. et al. ERK/MAPK regulates the Kv4.2 potassium channel by direct phosphorylation of the pore-forming subunit. Am. J. Physiol. Cell Physiol. 290, C852–C861 (2006).
    Article CAS PubMed Google Scholar
45. Cirelli, C. et al. Reduced sleep in Drosophila Shaker mutants. Nature 434, 1087–1092 (2005).
    Article CAS PubMed Google Scholar
46. Shaw, P.J., Tononi, G., Greenspan, R.J. & Robinson, D.F. Stress response genes protect against lethal effects of sleep deprivation in Drosophila. Nature 417, 287–291 (2002).
    Article CAS PubMed Google Scholar
47. Sokal, R.R. & Rohlf, F.J. Biometry: the Principles and Practice of Statistics in Biological Research (Freeman, New York, 1995).
    Google Scholar
48. Rosato, E. & Kyriacou, C.P. Analysis of locomotor activity rhythms in Drosophila. Nat. Protoc. 1, 559–568 (2006).
    Article PubMed Google Scholar
49. Roenneberg, T. & Taylor, W. Automated recordings of bioluminescence with special reference to the analysis of circadian rhythms. Methods Enzymol. 305, 104–119 (2000).
    Article CAS PubMed Google Scholar
50. Basyuk, E., Bertrand, E. & Journot, L. Alkaline fixation drastically improves the signal of in situ hybridization. Nucleic Acids Res. 28, E46 (2000).
    Article CAS PubMed PubMed Central Google Scholar

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