Neural stem cells from adult hippocampus develop essential properties of functional CNS neurons (original) (raw)

References

  1. Gage, F. H. Mammalian neural stem cells. Science 287, 1433–1438 (2000).
    Article CAS Google Scholar
  2. Temple, S. The development of neural stem cells. Nature 414, 112–117 (2001).
    Article CAS Google Scholar
  3. Weissman, I. L., Anderson, D. J. & Gage, F. Stem and progenitor cells: origins, phenotypes, lineage commitments, and transdifferentiations. Annu. Rev. Cell Dev. Biol. 17, 387–403 (2001).
    Article CAS Google Scholar
  4. Altman, J. & Das, G. D. Autoradiographic and histological evidence of postnatal neurogenesis in rats. J. Comp. Neurol. 124, 319–335 (1965).
    Article CAS Google Scholar
  5. Kaplan, M. S. & Hinds, J. W. Neurogenesis in the adult rat: electron microscopic analysis of light radioautographs. Science 197, 1092–1094 (1977).
    Article CAS Google Scholar
  6. van Praag, H. et al. Functional neurogenesis in the adult hippocampus. Nature 415, 1030–1034 (2002).
    Article CAS Google Scholar
  7. Reynolds, B. A. & Weiss, S. Generation of neurons and astrocytes from isolated cells of the adult mammalian central nervous system. Science 255, 1707–1710 (1992).
    Article CAS Google Scholar
  8. Lois, C. & Alvarez-Buylla, A. Proliferating subventricular zone cells in the adult mammalian forebrain can differentiate into neurons and glia. Proc. Natl. Acad. Sci. USA 90, 2074–2077 (1993).
    Article CAS Google Scholar
  9. Palmer, T. D., Markakis, E. A., Willhoite, A. R., Safar, F. & Gage, F.H. Fibroblast growth factor-2 activates a latent neurogenic program in neural stem cells from diverse regions of the adult CNS. J. Neurosci. 19, 8487–8497 (1999).
    Article CAS Google Scholar
  10. Brazelton, T. R., Rossi, F. M., Keshet, G. I. & Blau, H. M. From marrow to brain: expression of neuronal phenotypes in adult mice. Science 290, 1775–1779 (2000).
    Article CAS Google Scholar
  11. Mezey, E., Chandross, K. J., Harta, G., Maki, R. A. & McKercher, S. R. Turning blood into brain: cells bearing neuronal antigens generated in vivo from bone marrow. Science 290, 1779–1782 (2000).
    Article CAS Google Scholar
  12. Kondo, T. & Raff, M. Oligodendrocyte precursor cells reprogrammed to become multipotential CNS stem cells. Science 289, 1754–1757 (2000).
    Article CAS Google Scholar
  13. Roy, N. S. et al. In vitro neurogenesis by progenitor cells isolated from the adult human hippocampus. Nat. Med. 6, 271–277 (2000).
    Article CAS Google Scholar
  14. Woodbury, D., Schwarz, E. J., Prockop, D. J. & Black, I. B. Adult rat and human bone marrow stromal cells differentiate into neurons. J. Neurosci. Res. 61, 364–370 (2000).
    Article CAS Google Scholar
  15. Toma, J.G. et al. Isolation of multipotent adult stem cells from the dermis of mammalian skin. Nat. Cell Biol. 3, 778–784 (2001).
    Article CAS Google Scholar
  16. Toda, H., Takahashi, J., Mizoguchi, A., Koyano, K. & Hashimoto, N. Neurons generated from adult rat hippocampal stem cells form functional glutamatergic and GABAergic synapses in vitro. Exp. Neurol. 165, 66–76 (2000).
    Article CAS Google Scholar
  17. Finley, M. F., Kulkarni, N. & Huettner, J. E. Synapse formation and establishment of neuronal polarity by P19 embryonic carcinoma cells and embryonic stem cells. J. Neurosci. 16, 1056–1065 (1996).
    Article CAS Google Scholar
  18. Vicario-Abejon, C., Collin, C., Tsoulfas, P. & McKay, R. D. Hippocampal stem cells differentiate into excitatory and inhibitory neurons. Eur. J. Neurosci. 12, 677–688 (2000).
    Article CAS Google Scholar
  19. Kandel, E. R., Schwartz, J. H. & Jessell, T. M. Principles of Neural Science (McGraw-Hill, New York, 2000).
    Google Scholar
  20. Jessell, T. M. & Sanes, J. R. Development. The decade of the developing brain. Curr. Opin. Neurobiol. 10, 599–611 (2000).
    Article CAS Google Scholar
  21. Ullian, E. M., Sapperstein, S. K., Christopherson, K. S. & Barres, B. A. Control of synapse number by glia. Science 291, 657–661(2001).
    Article CAS Google Scholar
  22. Blondel, O. et al. A glia-derived signal regulating neuronal differentiation. J. Neurosci. 20, 8012–8020 (2000).
    Article CAS Google Scholar
  23. Palmer, T. D., Takahashi, J. & Gage, F. H. The adult rat hippocampus contains primordial neural stem cells. Mol. Cell. Neurosci. 8, 389–404 (1997).
    Article CAS Google Scholar
  24. Takahashi, J., Palmer, T. D. & Gage, F. H. Retinoic acid and neurotrophins collaborate to regulate neurogenesis in adult-derived neural stem cell cultures. J. Neurobiol. 38, 65–81 (1999).
    Article CAS Google Scholar
  25. Suhonen, J. O., Peterson, D. A., Ray, J. & Gage, F. H. Differentiation of adult hippocampus-derived progenitors into olfactory neurons in vivo. Nature 383, 624–627 (1996).
    Article CAS Google Scholar
  26. Song, H-J., Stevens, C. F. & Gage, F. H. Astroglia induce neurogenesis from adult stem cells. Nature (in press).
  27. Goslin, K., Asmussen, H. & Banker, G. in Culturing Nerve Cells (eds. Banker, G. & and Golsin, K.) 339–370 (MIT Press, Cambridge, Massachusetts, 1998).
    Google Scholar
  28. Sudhof, T. C. et al. Synapsins: mosaics of shared and individual domains in a family of synaptic vesicle phosphoproteins. Science 245, 1474–1480 (1989).
    Article CAS Google Scholar
  29. Bekkers, J. M. & Stevens, C. F. Excitatory and inhibitory autaptic currents in isolated hippocampal neurons maintained in cell culture. Proc. Natl. Acad. Sci. USA 88, 7834–7838 (1991).
    Article CAS Google Scholar
  30. Zaheer, A., Zhong, W., Uc, E. Y., Moser, D. R. & Lim, R. Expression of mRNAs of multiple growth factors and receptors by astrocytes and glioma cells: detection with reverse transcription–polymerase chain reaction. Cell. Mol. Neurobiol. 15, 221–237 (1995).
    Article CAS Google Scholar
  31. Nicholls, J. G., Martin, A. R. & Wallace, B. G. From Neuron To Brain: A Cellular and Molecular Approach to the Function of the Nervous System 3rd edn. 149–152 (Sinauer, Sunderland, Massachusetts, 1992).
    Google Scholar
  32. Taupin, P. et al., FGF-2–responsive neural stem cell proliferation requires CCg, a novel autocrine/paracrine cofactor. Neuron 28, 385–397 (2000).
    Article CAS Google Scholar
  33. Clarke, D. & Frisen, J. Differentiation potential of adult stem cells. Curr. Opin. Genet. Dev. 11, 575–580 (2001).
    Article CAS Google Scholar
  34. Ryder, E. F., Snyder, E. Y. & Cepko, C. L. Establishment and characterization of multipotent neural cell lines using retrovirus vector–mediated oncogene transfer. J. Neurobiol. 21, 356–375 (1990).
    Article CAS Google Scholar
  35. Sucher, N. J. et al. Expression of endogenous NMDAR1 transcripts without receptor protein suggests post-transcriptional control in PC12 cells. J. Biol. Chem. 268, 22299–22304 (1993).
    CAS PubMed Google Scholar
  36. Hales, T. G. & Tyndale, R. F. Few cell lines with GABAA mRNAs have functional receptors. J. Neurosci. 14, 5429–5436 (1994).
    Article CAS Google Scholar
  37. Ye, G., Song Liu, X., Pasternak, J. F. & Trommer, B. L. Maturation of glutamatergic neurotransmission in dentate gyrus granule cells. Brain Res. Dev. Brain Res. 124, 33–42 (2000).
    Article CAS Google Scholar
  38. Mehler, M. F., Rozental, R., Dougherty, M., Spray, D. C. & Kessler, J. A. Cytokine regulation of neuronal differentiation of hippocampal progenitor cells. Nature 362, 62–65 (1993).
    Article CAS Google Scholar
  39. Sah, D. W., Ray, J. & Gage, F. H. Regulation of voltage- and ligand-gated currents in rat hippocampal progenitor cells in vitro. J. Neurobiol. 32, 95–110 (1997).
    Article CAS Google Scholar
  40. Schubert, D. et al. Clonal cell lines from the rat central nervous system. Nature 249, 224–227 (1974).
    Article CAS Google Scholar
  41. Bekkers, J. M. & Stevens, C. F. NMDA and non-NMDA receptors are co-localized at individual excitatory synapses in cultured rat hippocampus. Nature 341, 230–233 (1989).
    Article CAS Google Scholar
  42. Auerbach, J. M., Eiden, M.V. & McKay, R. D. Transplanted CNS stem cells form functional synapses in vivo. Eur. J. Neurosci. 12, 1696–1704 (2000).
    Article CAS Google Scholar
  43. Mauch, D. H. et al. CNS synaptogenesis promoted by glia-derived cholesterol. Science 294, 1354–1357 (2001).
    Article CAS Google Scholar
  44. Haydon, P. G. Glia: listening and talking to the synapse. Nat. Rev. Neurosci. 2, 185–193 (2001).
    Article CAS Google Scholar
  45. Fitzsimonds, R. M., Song, H. J. & Poo, M. M. Propagation of activity-dependent synaptic depression in simple neural networks. Nature 388, 439–448 (1997).
    Article CAS Google Scholar
  46. Palmer, T. D., Thompson, A. R. & Miller, A. D. Production of human factor IX in animals by genetically modified skin fibroblasts: potential therapy for hemophilia B. Blood 73, 438–445 (1989).
    CAS PubMed Google Scholar
  47. Schwartz, J. P. & Wilson, D. J. Preparation and characterization of type 1 astrocytes cultured from adult rat cortex, cerebellum, and striatum. Glia 5, 75–80 (1992).
    Article CAS Google Scholar
  48. Nobel, M. & Mayer-Proschel, M. in Culturing Nerve Cells (eds. Banker, G. & Goslin, K.) 499–544 (MIT Press, Cambridge, Massachusetts, 1998).
    Google Scholar
  49. Schikorski, T. & Stevens, C. F. Morphological correlates of functionally defined synaptic vesicle populations. Nat. Neurosci. 4, 391–395 (2001).
    Article CAS Google Scholar
  50. Murthy, V. N., Sejnowski, T. J. & Stevens, C. F. Heterogeneous release properties of visualized individual hippocampal synapses. Neuron 18, 599–612 (1999).
    Article Google Scholar

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